Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel C. Bensen"'
Autor:
Leslie W Tari, Xiaoming Li, Michael Trzoss, Daniel C Bensen, Zhiyong Chen, Thanh Lam, Junhu Zhang, Suk Joong Lee, Grayson Hough, Doug Phillipson, Suzanne Akers-Rodriguez, Mark L Cunningham, Bryan P Kwan, Kirk J Nelson, Amanda Castellano, Jeff B Locke, Vickie Brown-Driver, Timothy M Murphy, Voon S Ong, Chris M Pillar, Dean L Shinabarger, Jay Nix, Felice C Lightstone, Sergio E Wong, Toan B Nguyen, Karen J Shaw, John Finn
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84409 (2013)
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA t
Externí odkaz:
https://doaj.org/article/61b9ed4eb647499192d901bd0163432e
Publikováno v:
SLAS Discovery. 18:1018-1026
The macromolecular synthesis assay was optimized in both S. aureus and E. coli imp and used to define patterns of inhibition of DNA, RNA, protein, and cell wall biosynthesis of several drug classes. The concentration of drug required to elicit pathwa
Autor:
Mark L. Cunningham, Doug Phillipson, Bryan P. Kwan, John T. Finn, Kirk J. Nelson, Sergio E. Wong, Michael Trzoss, Jeff B. Locke, Jay C. Nix, Vickie Brown-Driver, Felice C. Lightstone, Zhiyong Chen, Toan B. Nguyen, Karen J. Shaw, Suzanne Akers-Rodriguez, Xiaoming Li, Suk Joong Lee, Amanda Castellano, Dean L. Shinabarger, Timothy M. Murphy, Junhu Zhang, Leslie W. Tari, Chris M. Pillar, Voon Ong, Grayson Hough, Thanh Lam, Daniel C. Bensen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84409 (2013)
PLoS ONE
PLoS ONE
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA t
Autor:
Mark Stidham, Thanh Lam, Bryan P. Kwan, Mark L. Cunningham, Zhiyong Chen, Felice C. Lightstone, Junhu Zhang, Karen J. Shaw, Leslie W. Tari, Toan B. Nguyen, Christopher J. Creighton, John T. Finn, Xiaoming Li, Michael Trzoss, Daniel C. Bensen, Sergio E. Wong, Jay C. Nix
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication. The high degree of conservation in the ATP-binding pockets of these enzymes make them appea
Autor:
Vickie Brown-Driver, Christopher J. Creighton, John T. Finn, Toan B. Nguyen, Mark L. Cunningham, Zhiyong Chen, Amanda Castellano, Mark Stidham, Sergio E. Wong, Xiaoming Li, Karen J. Shaw, Thanh Lam, Junhu Zhang, Bryan P. Kwan, Kirk J. Nelson, Felice C. Lightstone, Leslie W. Tari, Daniel C. Bensen, Micheal Trzoss
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
The structurally related bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) have long been recognized as prime candidates for the development of broad spectrum antibacterial agents. However, GyrB/ParE targeting antibacterials with
Autor:
Daniel C, Bensen
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 841
One of the most important parameters correlated with success in protein crystallization experiments is sample purity and monodispersity. Heterologous expression systems have allowed investigators to produce engineered proteins in sufficient quantitie
Autor:
Daniel C. Bensen
Publikováno v:
Methods in Molecular Biology ISBN: 9781617795190
One of the most important parameters correlated with success in protein crystallization experiments is sample purity and monodispersity. Heterologous expression systems have allowed investigators to produce engineered proteins in sufficient quantitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd71fb7a673784207f902f69097faea
https://doi.org/10.1007/978-1-61779-520-6_3
https://doi.org/10.1007/978-1-61779-520-6_3
Autor:
Michael J. Hunter, Kirk J. Nelson, Ronald V. Swanson, Duncan E. McRee, Jay C. Nix, Daniel C. Bensen, Leslie W. Tari, Isaac Hoffman
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(3)
The 2.25 A crystal structure of a complex of Aurora A kinase (AIKA) with cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide 1 is described here. The inhibitor binding mode is novel, with the cycloprop
Autor:
Jefferey L. Stein, Robert A. Feldman, Heidi Seitz, Lance T. Taylor, Oded Béjà, L. Aravind, Ronald V. Swanson, Eugene V. Koonin, Edward F. DeLong, Daniel C. Bensen
Planktonic crenarchaeotes are present in high abundance in Antarctic winter surface waters, and they also make up a large proportion of total cell numbers throughout deep ocean waters. To better characterize these uncultivated marine crenarchaeotes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902ad6fe078f437cf1a724c2c5a379b5
https://europepmc.org/articles/PMC126555/
https://europepmc.org/articles/PMC126555/