Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Daniel C Nelson"'
Autor:
Yang Shen, Marilia Barros, Tarek Vennemann, D Travis Gallagher, Yizhou Yin, Sara B Linden, Ryan D Heselpoth, Dennis J Spencer, David M Donovan, John Moult, Vincent A Fischetti, Frank Heinrich, Mathias Lösche, Daniel C Nelson
Publikováno v:
eLife, Vol 5 (2016)
PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections. We show that the PlyC holoenzyme, m
Externí odkaz:
https://doaj.org/article/aed840bf4c004cdc92ae7baba09aee44
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112939 (2014)
Alginate is a polysaccharide produced by certain seaweeds and bacteria that consists of mannuronic acid and guluronic acid residues. Seaweed alginate is used in food and industrial chemical processes, while the biosynthesis of bacterial alginate is a
Externí odkaz:
https://doaj.org/article/2d51a7de4b69456b89283fa17a1663e8
Autor:
Chen Chen, Patrick Bales, Julia Greenfield, Ryan D Heselpoth, Daniel C Nelson, Osnat Herzberg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93156 (2014)
Bacteriophage tailspike proteins act as primary receptors, often possessing endoglycosidase activity toward bacterial lipopolysaccharides or other exopolysaccharides, which enable phage absorption and subsequent DNA injection into the host. Phage CBA
Externí odkaz:
https://doaj.org/article/e62f58243eb1407798520927eaa807e1
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67950 (2013)
In bacterial biofilms, high molecular weight, secreted exopolysaccharides can serve as a scaffold to which additional carbohydrates, proteins, lipids, and nucleic acids adhere, forming the matrix of the developing biofilm. Here we report methods to e
Externí odkaz:
https://doaj.org/article/c12c5708027748789af1125831116426
Autor:
Adit B. Alreja, Amanda E. Appel, Jinyi C. Zhu, Sean P. Riley, Norberto Gonzalez-Juarbe, Daniel C. Nelson
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTStreptococcus pneumoniae (Spn), a Gram-positive bacterium, is responsible for causing a wide variety of invasive infections. The emergence of multi-drug antibiotic resistance has prompted the search for antimicrobial alternatives. Phage-deriv
Externí odkaz:
https://doaj.org/article/2da6a8537ea942b5b5f649741e1a70ef
Autor:
Shelby D. Foor, Kalvis Brangulis, Anil K. Shakya, Vipin S. Rana, Sandhya Bista, Chrysoula Kitsou, Michael Ronzetti, Adit B. Alreja, Sara B. Linden, Amanda S. Altieri, Bolormaa Baljinnyam, Inara Akopjana, Daniel C. Nelson, Anton Simeonov, Osnat Herzberg, Melissa J. Caimano, Utpal Pal
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Borrelia burgdorferi, the pathogen of Lyme disease, encodes many conserved proteins of unknown structure or function, including ones that serve essential roles in microbial infectivity. One such protein is BB0238, which folds into a two-doma
Externí odkaz:
https://doaj.org/article/41e800ac2ac0401a9b693dae646e6521
Autor:
Marek Adam Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Maria Kaźmierczak, Paulina Miernikiewicz, Joanna Marta Majewska, Wiktoria Budziar, Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic a
Externí odkaz:
https://doaj.org/article/921cc27f8a7645c29fa84e3ab39311ad
Publikováno v:
Biology, Vol 12, Iss 10, p 1277 (2023)
Bacteriophage endolysins degrade the bacterial peptidoglycan and are considered enzymatic alternatives to small-molecule antibiotics. In particular, the multimeric streptococcal endolysin PlyC has appealing antibacterial properties. However, a compre
Externí odkaz:
https://doaj.org/article/2cbd8116aed54495b8fe11f3f24006a5
Autor:
Adit B. Alreja, Sara B. Linden, Harrison R. Lee, Kinlin L. Chao, Osnat Herzberg, Daniel C. Nelson
Publikováno v:
ACS Infectious Diseases. 9:1092-1104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4e056085a1f3ee73367502dda807c2
https://doi.org/10.1021/acsinfecdis.2c00627
https://doi.org/10.1021/acsinfecdis.2c00627
Autor:
Marek Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Kaźmierczak, Paulina Miernikiewicz, Joanna Majewska, Wiktoria Budziar, Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska
Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune responsein vivo. In this study, we used a targeted modification of two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino-acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38fa7a194826e4835f5008880510760e
https://doi.org/10.1101/2022.10.06.511193
https://doi.org/10.1101/2022.10.06.511193
