Zobrazeno 1 - 10
of 646
pro vyhledávání: '"Daniel C Link"'
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000807 (2020)
Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to te
Externí odkaz:
https://doaj.org/article/dfcc01b5a9e84be9b30dca2343479fa0
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233751 (2020)
Mesenchymal stromal cells are an important component of the bone marrow hematopoietic niche. Prior studies showed that signaling from members of the transforming growth factor (TGF) superfamily in mesenchymal stromal cells is required for normal nich
Externí odkaz:
https://doaj.org/article/2462d614da9846c1b050a115b13aa141
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Canxin Xu, Dustin Kress, Roberto Civitelli, Yousef Abu-Amer, Thirumala-Devi Kanneganti, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e3000047 (2018)
Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of autoinflammatory disorders known as cryopyrinopathies of which neonatal-onset multisystem inflammato
Externí odkaz:
https://doaj.org/article/266b07cae49e41b7aebe6122e5a1256f
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119304 (2015)
MIR233 is genetically or epigenetically silenced in a subset of acute myeloid leukemia (AML). MIR223 is normally expressed throughout myeloid differentiation and highly expressed in hematopoietic stem cells (HSCs). However, the contribution of MIR223
Externí odkaz:
https://doaj.org/article/b6f2776026db483b93c3aba60efec152
Autor:
Andrew E O Hughes, Vincent Magrini, Ryan Demeter, Christopher A Miller, Robert Fulton, Lucinda L Fulton, William C Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F Conrad, Brian S White, Jin Shao, Daniel C Link, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Matthew J Walter, Timothy A Graubert
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004462 (2014)
Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-w
Externí odkaz:
https://doaj.org/article/1777fa4a2cbc4a6098dfc41effa04000
Autor:
Agata Gruszczynska, Abhishek Maiti, Christopher A. Miller, Sai Mukund Ramakrishnan, Daniel C. Link, Geoffrey L. Uy, Allegra A. Petti, Kala Hayes, Courtney D. DiNardo, Farhad Ravandi, Timothy J. Ley, David H. Spencer, Feng Gao, Marina Y. Konopleva, John S. Welch
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/68bab4a8237f41da908adeab2a2bab9b
Autor:
Melissa G Hunter, Morgan McLemore, Daniel C Link, Megan Loveland, Alexander Copelan, Belinda R Avalos
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2452 (2008)
Expression of truncated G-CSFR forms in patients with SCN/AML induces hyperproliferation and prolonged cell survival. Previously, we showed that ligand internalization is delayed and degradation of truncated G-CSFR forms is defective in patients with
Externí odkaz:
https://doaj.org/article/563746a946664b6cacb7527d947f3779
Autor:
Peng Lu, Karolyn A. Oetjen, Diane E. Bender, Marianna B. Ruzinova, Daniel A. C. Fisher, Kevin G. Shim, Russell K. Pachynski, W. Nathaniel Brennen, Stephen T. Oh, Daniel C. Link, Daniel L. J. Thorek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.
Externí odkaz:
https://doaj.org/article/4afb3a53b1ba47098abd1d17ba0fa669
Autor:
Laneshia K. Tague, Karolyn A. Oetjen, Anirudh Mahadev, Matthew J. Walter, Hephzibah Anthony, Daniel Kreisel, Daniel C. Link, Andrew E. Gelman
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
BACKGROUND Cellular stressors influence the development of clonal hematopoiesis (CH). We hypothesized that environmental, inflammatory, and genotoxic stresses drive the emergence of CH in lung transplant recipients. METHODS We performed a cross-secti
Externí odkaz:
https://doaj.org/article/a83352bd9ffe474699ed8b5770c128f7
Autor:
Francesca Ferraro, Agata Gruszczynska, Marianna B. Ruzinova, Christopher A. Miller, Mary Elizabeth Percival, Geoffrey L. Uy, Iskra Pusic, Meagan A. Jacoby, Mathew J. Christopher, Miriam Y. Kim, Peter Westervelt, Amanda F. Cashen, Mark A. Schroeder, John F. DiPersio, Camille N. Abboud, Lukas D. Wartman, Feng Gao, Daniel C. Link, Timothy J. Ley, John S. Welch
Publikováno v:
Haematologica, Vol 107, Iss 7 (2022)
Externí odkaz:
https://doaj.org/article/a2116fd8e43648e69c98851780c8a622