Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daniel C Ellwanger"'
Autor:
Eva C Schulte, Immanuel Stahl, Darina Czamara, Daniel C Ellwanger, Sebastian Eck, Elisabeth Graf, Brit Mollenhauer, Alexander Zimprich, Peter Lichtner, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Annette Peters, Christian Gieger, Bertram Müller-Myhsok, Claudia Trenkwalder, Juliane Winkelmann
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79145 (2013)
Approximately 20% of individuals with Parkinson's disease (PD) report a positive family history. Yet, a large portion of causal and disease-modifying variants is still unknown. We used exome sequencing in two affected individuals from a family with l
Externí odkaz:
https://doaj.org/article/6d1d769b4010442386e3a3a4e834472e
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36694 (2012)
Genome-wide association studies (GWAS) have become an effective tool to map genes and regions contributing to multifactorial human diseases and traits. A comparably small number of variants identified by GWAS are known to have a direct effect on prot
Externí odkaz:
https://doaj.org/article/e52c0fcd9247464aa9734f28834caea3
Autor:
Yi Huo, Zhen Sheng, Daniel R. Lu, Daniel C. Ellwanger, Chi-Ming Li, Oliver Homann, Songli Wang, Hong Yin, Ruibao Ren
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Bi-specific T-cell engager (BiTE) antibody is a class of bispecific antibodies designed for cancer immunotherapy. Blinatumomab is the first approved BiTE to treat acute B cell lymphoblastic leukemia (B-ALL). It brings killer T and
Externí odkaz:
https://doaj.org/article/88b9f96ffc8c48f29c00d36e749723dc
Autor:
Tracy M. Yamawaki, Daniel R. Lu, Daniel C. Ellwanger, Dev Bhatt, Paolo Manzanillo, Vanessa Arias, Hong Zhou, Oh Kyu Yoon, Oliver Homann, Songli Wang, Chi-Ming Li
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background Elucidation of immune populations with single-cell RNA-seq has greatly benefited the field of immunology by deepening the characterization of immune heterogeneity and leading to the discovery of new subtypes. However, single-cell
Externí odkaz:
https://doaj.org/article/e6c3edf6b23b4041b41e0ead257ffb4d
Autor:
Taha A. Jan, Yasmin Eltawil, Angela H. Ling, Leon Chen, Daniel C. Ellwanger, Stefan Heller, Alan G. Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109358- (2021)
Summary: The utricle is a vestibular sensory organ that requires mechanosensitive hair cells to detect linear acceleration. In neonatal mice, new hair cells are derived from non-sensory supporting cells, yet cell type diversity and mechanisms of cell
Externí odkaz:
https://doaj.org/article/bdb1a3a13c974879be4f6ec0ce0dd8cd
Autor:
Amanda Janesick, Mirko Scheibinger, Nesrine Benkafadar, Sakin Kirti, Daniel C. Ellwanger, Stefan Heller
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108900- (2021)
Summary: In contrast to mammals, birds recover naturally from acquired hearing loss, which makes them an ideal model for inner ear regeneration research. Here, we present a validated single-cell RNA sequencing resource of the avian cochlea. We descri
Externí odkaz:
https://doaj.org/article/b654f2dc803a4af6a29c5d4aceaa3c3e
Autor:
Songli Wang, Zhen Sheng, Ruibao Ren, Daniel R. Lu, Chi-Ming Li, Yi Huo, Hong Yin, Oliver Homann, Daniel C. Ellwanger
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BMC Genomics
BMC Genomics
Introduction Blinatumomab, a bi-specific T cell engager (BiTE®) combining the VH and VL domains of two antibodies against human CD19 and CD3, has been approved by U.S. Food and Drug Administration (FDA) for the treatment of patients with relapsed or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb1f330521962e2d5c9efcc5655ede2
https://doaj.org/article/88b9f96ffc8c48f29c00d36e749723dc
https://doaj.org/article/88b9f96ffc8c48f29c00d36e749723dc
Autor:
Mirko Scheibinger, Amanda Janesick, Nesrine Benkafadar, Daniel C. Ellwanger, Taha A. Jan, Stefan Heller
Publikováno v:
Cell reports. 40(13)
The avian utricle, a vestibular organ of the inner ear, displays turnover of sensory hair cells throughout life. This is in sharp contrast to the mammalian utricle, which shows limited regenerative capacity. Here, we use single-cell RNA sequencing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c645ced10473b1ea2aa3b44c324e3
https://pubmed.ncbi.nlm.nih.gov/36170825
https://pubmed.ncbi.nlm.nih.gov/36170825
Autor:
Dawn Weishuhn, Simone Brioschi, Diana Cha, Marco Colonna, Daniel Yoo, Sara Rao, Samuel A. Hasson, Jodi Bradley, Peng Luan, Ian Foltz, Shilpa Sambashivan, Shoutang Wang, Daniel C. Ellwanger, Menno Van Lookeren Campagne, Susan Gilfillan, Palaniswami Rathanaswami, Ryan Case, Lydia Green, Zhifei Shao
Publikováno v:
Proc Natl Acad Sci U S A
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer’s disease (AD) risk is associated with the TREM2(R47H) variant, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e7e2a0334e1a0bf5f3ff55b8cfd453
https://doi.org/10.1073/pnas.2017742118
https://doi.org/10.1073/pnas.2017742118
Autor:
Taha A. Jan, Daniel C. Ellwanger, Amanda Janesick, Mirko Scheibinger, Stefan Heller, Nesrine Benkafadar
Publikováno v:
SSRN Electronic Journal.
The avian utricle, a vestibular organ of the inner ear, displays turnover of sensory hair cells throughout life. This is in sharp contrast to the mammalian utricle, which shows limited regenerative capacity. Here, we use single-cell RNA-sequencing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff01875d6e31d16c117c350dfbb763d6
https://doi.org/10.2139/ssrn.3831459
https://doi.org/10.2139/ssrn.3831459