A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion

Autor: Jan Zalesak, Birgit Habenstein, Thomas C. Marlovits, Mélanie Berbon, Antoine Loquet, Daniel C. Desrosiers, Emily Z. Guo, James Tolchard, Jorge E. Galán

Publikováno v: PLoS biology 17(7), e3000351-(2019). doi:10.1371/journal.pbio.3000351
Plos Biology
Plos Biology, 2019, 17 (7), pp.e3000351. ⟨10.1371/journal.pbio.3000351⟩
PLOS Biology
PLoS Biology, Vol 17, Iss 7, p e3000351 (2019)
PLoS Biology

Type III protein-secretion machines are essential for the interactions of many pathogenic or symbiotic bacterial species with their respective eukaryotic hosts. The core component of these machines is the injectisome, a multiprotein complex that medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb80a469b093eda6be53bcb488f3c73
https://doi.org/10.1371/journal.pbio.3000351

TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein

Autor: Juan C. Salazar, Arvind Anand, Star Dunham-Ems, Azad Eshghi, Caroline E. Cameron, Morgan LeDoyt, Amit Luthra, Daniel C. Desrosiers, Justin D. Radolf, Michael A. D. Cummings, Adriana R. Cruz, Melissa J. Caimano

Publikováno v: Molecular Microbiology. 80:1496-1515

Definitive identification of Treponema pallidum rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in T. pallidum with sequence homology to a Gram-negative OMP, belongs to the BamA family of proteins essential f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0da329f09cc22a8c9624f88120f27e0
https://doi.org/10.1111/j.1365-2958.2011.07662.x

Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum

Autor: David L. Cox, Karsten R. O. Hazlett, Leslie B. Poole, Derek Parsonage, Kimberly J. Nelson, Yongcheng Sun, Daniel C. Desrosiers, Justin D. Radolf

Publikováno v: Proceedings of the National Academy of Sciences. 107:6240-6245

Little is known about the mechanisms by which Treponema pallidum ( Tp ), the causative agent of syphilis, copes with oxidative stress as it establishes persistent infection within its obligate human host. The Tp genomic sequence indicates that the ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e265d6dd1bcb00dd4ade4aaae0a12d7
https://doi.org/10.1073/pnas.0910057107

The general transition metal (Tro) and Zn2+(Znu) transporters inTreponema pallidum: analysis of metal specificities and expression profiles

Autor: Justin D. Radolf, Yong Cheng Sun, David L. Cox, Akbar A. Zaidi, Daniel C. Desrosiers, Christian H. Eggers

Publikováno v: Molecular Microbiology. 65:137-152

Acquisition of transition metals is central to the struggle between a bacterial pathogen and its mammalian host. Previous studies demonstrated that Treponema pallidum encodes a cluster-9 (C9) ABC transporter (troABCD) whose solute-binding protein com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c3dd16a48fa534aec1b216ed5dfa91
https://doi.org/10.1111/j.1365-2958.2007.05771.x

TP0453, a Concealed Outer Membrane Protein of Treponema pallidum , Enhances Membrane Permeability

Autor: Carson J. La Vake, Robert Brasseur, Morgan E. La Vake, Marc Decaffmeyer, Karsten R. O. Hazlett, Esther J. Robinson, Kenneth W. Bourell, Michael P. Bennett, Justin D. Radolf, David L. Cox, Daniel C. Desrosiers

Publikováno v: Journal of Bacteriology. 187:6499-6508

The outer membrane of Treponema pallidum , the noncultivable agent of venereal syphilis, contains a paucity of protein(s) which has yet to be definitively identified. In contrast, the outer membranes of gram-negative bacteria contain abundant immunog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707a688c93545c478028ae812cec8c3f
https://doi.org/10.1128/jb.187.18.6499-6508.2005