Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel C Brock"'
Autor:
Anupam K. Mondal, Daniel C. Brock, Sheldon Rowan, Zhi-Hong Yang, Krishna Vamsi Rojulpote, Kelsey M. Smith, Sarah G. Francisco, Eloy Bejarano, Milton A. English, Amy Deik, Sarah Jeanfavre, Clary B. Clish, Alan T. Remaley, Allen Taylor, Anand Swaroop
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108979- (2024)
Summary: A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In
Externí odkaz:
https://doaj.org/article/b13e6864cc514103b6dadb00ab4c518b
Autor:
Zhi-Hong Yang, Aruna Gorusupudi, Todd A. Lydic, Anupam K. Mondal, Seizo Sato, Isao Yamazaki, Hideaki Yamaguchi, Jingrong Tang, Krishna Vamsi Rojulpote, Anna B. Lin, Hannah Decot, Hannah Koch, Daniel C. Brock, Ranganathan Arunkumar, Zhen-Dan Shi, Zu-Xi Yu, Milton Pryor, Julia F. Kun, Rolf E. Swenson, Anand Swaroop, Paul S. Bernstein, Alan T. Remaley
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108411- (2023)
Summary: Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field. We produced an n-3 C24-28-ri
Externí odkaz:
https://doaj.org/article/74a7d220a4254a238343bbd4e714de34
Autor:
Andrew J. Smith, Jayshree Advani, Daniel C. Brock, Jacob Nellissery, Jessica Gumerson, Lijin Dong, L. Aravind, Breandán Kennedy, Anand Swaroop
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacte
Externí odkaz:
https://doaj.org/article/abca2390cef14d15a89a878365c6270a
Autor:
James B. Hurley, William Ge, Brian M. Robbings, Kaitlyn M Rutter, Kristine Tsantilas, Susan E. Brockerhoff, Whitney M. Cleghorn, Kellie C Kuch, Edward D Parker, Daniel C Brock, Michelle M. Giarmarco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mitochondria are organelles that make cellular energy. In the retina, mitochondrial health is important for photoreceptor cell function and normal vision. Photoreceptors need more energy at night, but it is unclear how their mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61053d6e2b310544c47ab213051be41d
https://doi.org/10.1073/pnas.2007827117
https://doi.org/10.1073/pnas.2007827117
Autor:
Edward D Parker, Frans Vinberg, William Ge, Whitney M. Cleghorn, James B. Hurley, Rachel Hutto, Susan E. Brockerhoff, Celia M. Bisbach, Benjamin H Bauer, Daniel C Brock, Fatima Abbas
Publikováno v:
Cell Death & Differentiation. 27:1067-1085
Photoreceptors are specialized neurons that rely on Ca2+ to regulate phototransduction and neurotransmission. Photoreceptor dysfunction and degeneration occur when intracellular Ca2+ homeostasis is disrupted. Ca2+ homeostasis is maintained partly by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12bbbb35d9190fdd1120ab7bec0fd95
https://doi.org/10.1038/s41418-019-0398-2
https://doi.org/10.1038/s41418-019-0398-2
Autor:
Susan E. Brockerhoff, Kaitlyn M Rutter, Daniel C Brock, Whitney M. Cleghorn, Michelle M. Giarmarco, Brian M. Robbings, William Ge, Kristine Tsantilas, Kellie C Kuch, Edward D Parker
Cone photoreceptors in the retina are exposed to intense daylight, and have higher energy demands in darkness. Cones produce energy using a large cluster of mitochondria. Mitochondria are susceptible to oxidative damage, and healthy mitochondrial pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba794f14d1f3d19e777cc6236d4b26
https://doi.org/10.1101/2020.04.10.030262
https://doi.org/10.1101/2020.04.10.030262
Autor:
Jianhai Du, Zachary S. Chambers, Justin M. Kollman, Yekai Wang, Anika L. Burrell, Daniel C. Brock, Michelle M. Giarmarco, Whitney M. Cleghorn, Susan E. Brockerhoff
Publikováno v:
The Journal of Biological Chemistry
Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that are unknown. Here, we sought to provide s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13701d88bc1f435c5ebbe39786ce555
https://doi.org/10.1016/j.jbc.2021.101441
https://doi.org/10.1016/j.jbc.2021.101441
Autor:
Rachel A, Hutto, Celia M, Bisbach, Fatima, Abbas, Daniel C, Brock, Whitney M, Cleghorn, Edward D, Parker, Benjamin H, Bauer, William, Ge, Frans, Vinberg, James B, Hurley, Susan E, Brockerhoff
Publikováno v:
Cell Death and Differentiation
Photoreceptors are specialized neurons that rely on Ca2+ to regulate phototransduction and neurotransmission. Photoreceptor dysfunction and degeneration occur when intracellular Ca2+ homeostasis is disrupted. Ca2+ homeostasis is maintained partly by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6873b7d33b678d15c55b773ac4791048
https://pubmed.ncbi.nlm.nih.gov/31371786
https://pubmed.ncbi.nlm.nih.gov/31371786
Autor:
Whitney M. Cleghorn, Rachel Hutto, James B. Hurley, Edward D Parker, William Ge, Daniel C Brock, Benjamin H Bauer, Celia M. Bisbach, Frans Vinberg, Susan E. Brockerhoff, Fatima Abbas
Mitochondrial Ca2+regulates key cellular processes including cytosolic Ca2+signals, energy production, and susceptibility to apoptosis. Photoreceptors are specialized neurons that have extraordinarily high energy demands and rely on cytosolic Ca2+sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a1a4a48aef85de22cbf05cd2ce6646