Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel C, Talley"'
Autor:
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination
Externí odkaz:
https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f
Autor:
Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotyp
Externí odkaz:
https://doaj.org/article/3166e3dd3b5945e88b4f3c4eb22c8065
Autor:
Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C. Talley, Ganesha Rai, Dingyin Tao, Christopher A. LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L. Quinney, Susan E. Boyles, Deborah M. Cholon, Martina Gentzsch, Mark J. Henderson, Fengtian Xue, Shengyun Fang
Publikováno v:
Molecular biology of the cell. 33(13)
RNF5 has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections. This study developed a small molecule inhibitor and degrader of the RNF5 ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a940a76247f973dab21cfd16e9778c6f
https://pubmed.ncbi.nlm.nih.gov/36074076
https://pubmed.ncbi.nlm.nih.gov/36074076
Autor:
Wei Zheng, Jun Choe, Ganesha Rai, Catherine Z. Chen, Alexey V. Zakharov, Matthew D. Hall, Miao Xu, Bolormaa Baljinnyam, Sankalp Jain, Daniel C. Talley, Quinlin M Hanson, Wei Zhu, Min Shen, Xin Hu, Anton Simeonov
Publikováno v:
ACS Pharmacology & Translational Science. 4:1675-1688
The National Center for Advancing Translational Sciences (NCATS) has been actively generating SARS-CoV-2 high-throughput screening data and disseminates it through the OpenData Portal (https://opendata.ncats.nih.gov/covid19/). Here, we provide a hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4193f0567c7e2ad60a071f22dd1a9d
https://doi.org/10.1021/acsptsci.1c00176
https://doi.org/10.1021/acsptsci.1c00176
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
https://doi.org/10.1021/acs.jmedchem.1c00034
https://doi.org/10.1021/acs.jmedchem.1c00034
Autor:
Joshua E. Hochuli, Sankalp Jain, Cleber Melo-Filho, Zoe L. Sessions, Tesia Bobrowski, Jun Choe, Johnny Zheng, Richard Eastman, Daniel C. Talley, Ganesha Rai, Anton Simeonov, Alexander Tropsha, Eugene N. Muratov, Bolormaa Baljinnyam, Alexey V. Zakharov
The COVID-19 pandemic has had enormous health, economic, and social consequences. Vaccines have been successful in reducing rates of infection and hospitalization, but there is still a need for an acute treatment for the disease. We investigate wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaf70f4f9f42259f111df973fc5340c
https://doi.org/10.1101/2022.03.15.484484
https://doi.org/10.1101/2022.03.15.484484
Autor:
Tyler B. J. Pinter, Adnan Baker-Agha, Abigail C. Jackson, Dhruvil Patel, Daniel C. Talley, Paul J. Smith, Katherine J. Franz
Publikováno v:
ChemMedChem
Bacterial expression of β-lactamase enzymes that hydrolyze β-lactam antibiotics contributes to the growing threat of antibacterial drug resistance. Metallo-β-lactamases, such as NDM-1, use catalytic zinc ions in their active sites and hydrolyze ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b248d2baedce4f9b7234a0074e32d2
https://doi.org/10.1002/cmdc.202000607
https://doi.org/10.1002/cmdc.202000607
Autor:
Kazuaki Chayama, Zongyi Hu, Amy Wang, Derek Le, Christopher D. Ma, Daniel C. Talley, Takuro Uchida, Noel Southall, Kelin Li, Adam Rolt, Mitsutaka Osawa, Xin Hu, Seung Bum Park, Tsanyang Jake Liang, Andrés E. Dulcey, Parker H. Irvin, Juan J. Marugan, Yuji Teraoka, Xin Xu, Kevin J. Frankowski, Nishanth Chalasani, Michio Imamura
Publikováno v:
Nature microbiology
Fluoxazolevir is an aryloxazole-based entry inhibitor of hepatitis C virus (HCV). We show that fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 to prevent fusion. Nine of ten fluoxazolevir resistance-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599048514549248633a057456d799d9
https://doi.org/10.1038/s41564-020-0781-2
https://doi.org/10.1038/s41564-020-0781-2
Autor:
Alexey V. Zakharov, Darrell L. Peterson, Adam Yasgar, Ajit Jadhav, Daniel C. Talley, Rong Huang, Anton Simeonov, Guangping Dong, Ken Chih-Chien Cheng
Publikováno v:
ACS Comb Sci
Methyltransferases (MTases) play diverse roles in cellular processes. Aberrant methylation levels have been implicated in many diseases, indicating the need for the identification and development of small molecule inhibitors for each MTase. Specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6109562be054866a6aeb1915d662ef
https://doi.org/10.1021/acscombsci.0c00077
https://doi.org/10.1021/acscombsci.0c00077
Autor:
Sankalp, Jain, Daniel C, Talley, Bolormaa, Baljinnyam, Jun, Choe, Quinlin, Hanson, Wei, Zhu, Miao, Xu, Catherine Z, Chen, Wei, Zheng, Xin, Hu, Min, Shen, Ganesha, Rai, Matthew D, Hall, Anton, Simeonov, Alexey V, Zakharov
Publikováno v:
ACS Pharmacology & Translational Science
The National Center for Advancing Translational Sciences (NCATS) has been actively generating SARS-CoV-2 high-throughput screening data and disseminates it through the OpenData Portal (https://opendata.ncats.nih.gov/covid19/). Here, we provide a hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::471c1e066843eee34b855aa53d90a57b
https://pubmed.ncbi.nlm.nih.gov/34608449
https://pubmed.ncbi.nlm.nih.gov/34608449