Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Daniel C, Schmitt"'
Publikováno v:
Advanced Synthesis & Catalysis. 364:1724-1731
Annulated heteroaromatics can be accessed through the addition of malonyl radicals onto heterocycles. Current methods are applicable to electron-rich heteroaromatics and reliant on transition metals or toxic tin reagents. Here we report a metal-free,
Autor:
Juan J. Rojas, Rosemary A. Croft, Alistair J. Sterling, Edward L. Briggs, Daniele Antermite, Daniel C. Schmitt, Luka Blagojevic, Peter Haycock, Andrew J. P. White, Fernanda Duarte, Chulho Choi, James J. Mousseau, James A. Bull
Publikováno v:
Nature Chemistry. 14:160-169
Bioisosteres provide valuable design elements for medicinal chemists to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisosteres for
Autor:
Edward L. Conn, Matthew A. Perry, Kecheng Shi, Guotao Wang, Susan Hoy, Neal W. Sach, Wenying Qi, Liqiang Qu, Yu Gao, Yan Xu, Daniel C. Schmitt
Publikováno v:
Organic & Biomolecular Chemistry. 20:3747-3754
α-Branched heteroaryl amines are prevalent motifs in drugs and are typically prepared through C-N bond formation. In contrast, C-C bond-forming approaches to branched amines may dramatically expand available chemical space but are rarely pursued in
Autor:
Daniel C. Schmitt, Paul F. Richardson, Tyler G. Saint-Denis, Jason S. Chen, Yajing Lian, Kevin D. Hesp, Nelson Y. S. Lam, Nikita Chekshin, Jin-Quan Yu, Chan Woo Huh, Jeff Elleraas
Publikováno v:
ACS Catal
Enantioselective C(sp(3))–H activation has gained considerable attention from the synthetic chemistry community. Despite the intense interest in these reactions, the mechanisms responsible for enantioselection are still vague. In the course of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3289d8d5c73f1ac6d9aa498e6a1e083a
https://europepmc.org/articles/PMC9098185/
https://europepmc.org/articles/PMC9098185/
Autor:
Phil S. Baran, Tian Qin, Justine N. de Gruyter, Michael R. Collins, Kap Sun Yeung, Shengyang Ni, Gary M. Gallego, David R. Langley, Jennifer X. Qiao, Paul Michael Scola, James J. Mousseau, Daniel C. Schmitt, Michael A. Poss, Rohan R. Merchant, Shouliang Yang, Alberto F. Garrido-Castro
Publikováno v:
Angewandte Chemie. 130:14768-14773
The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, t
Autor:
Juan J, Rojas, Rosemary A, Croft, Alistair J, Sterling, Edward L, Briggs, Daniele, Antermite, Daniel C, Schmitt, Luka, Blagojevic, Peter, Haycock, Andrew J P, White, Fernanda, Duarte, Chulho, Choi, James J, Mousseau, James A, Bull
Publikováno v:
Nature chemistry. 14(2)
Bioisosteres provide valuable design elements that medicinal chemists can use to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisost
Publikováno v:
ACS combinatorial science. 22(1)
An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-dianiline
Autor:
Amy Brault, Leslie Anthony Dakin, Fabien Vincent, Reto Horst, James F. Smith, John I. Trujillo, Darren Dumlao, Laura J. Byrnes, Daniel C. Schmitt, Suman Shanker, Justin Hall, Ann Aulabaugh, Jimson Wong, Matt Griffor, Hong Wang, Erik C. Ralph
Publikováno v:
Protein Science. 26:2367-2380
Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2ʹ,3ʹ-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while
Autor:
Tian Qin, Julien C. Vantourout, Michael R. Collins, Phil S. Baran, Shouliang Yang, Pavlo S. Lebed, Pavel K. Mykhailiuk, Cian Kingston, Jacob T. Edwards, Jason S. Chen, Robert J. Cherney, Rohan R. Merchant, Natalia M. Padial, Daniel C. Schmitt, Brittany Sanchez, Gary M. Gallego, Matthew A. Perry, Monika M. Kruszyk, James J. Mousseau, Shengyang Ni
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Journal of the American Chemical Society
instname
Journal of the American Chemical Society
We would like to thank Enamine Ltd for providing samples of several acids. We are grateful to Dr. Dee- Hua Huang and Dr. Laura Pasternack (Scripps Research) for assistance with nuclear magnetic resonance (NMR) spectroscopy and Mr. Andrew Badwal (Pfiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddbb19e7bf9b728018562965565794c
http://hdl.handle.net/10481/59869
http://hdl.handle.net/10481/59869
Publikováno v:
ACS combinatorial science. 20(5)
A modular, two-pot assembly of 7-arylpyrazolo[1,5- a]pyrimidones from aryl/heteroaryl halides and aminopyrazoles in library format was developed. Sonogashira coupling of aryl bromides with triethyl orthopropiolate, followed by in situ orthoester hydr