Zobrazeno 1 - 10
of 646
pro vyhledávání: '"Daniel C, Link"'
Autor:
Agata Gruszczynska, Abhishek Maiti, Christopher A. Miller, Sai Mukund Ramakrishnan, Daniel C. Link, Geoffrey L. Uy, Allegra A. Petti, Kala Hayes, Courtney D. DiNardo, Farhad Ravandi, Timothy J. Ley, David H. Spencer, Feng Gao, Marina Y. Konopleva, John S. Welch
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/68bab4a8237f41da908adeab2a2bab9b
Autor:
Peng Lu, Karolyn A. Oetjen, Diane E. Bender, Marianna B. Ruzinova, Daniel A. C. Fisher, Kevin G. Shim, Russell K. Pachynski, W. Nathaniel Brennen, Stephen T. Oh, Daniel C. Link, Daniel L. J. Thorek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.
Externí odkaz:
https://doaj.org/article/4afb3a53b1ba47098abd1d17ba0fa669
Autor:
Laneshia K. Tague, Karolyn A. Oetjen, Anirudh Mahadev, Matthew J. Walter, Hephzibah Anthony, Daniel Kreisel, Daniel C. Link, Andrew E. Gelman
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
BACKGROUND Cellular stressors influence the development of clonal hematopoiesis (CH). We hypothesized that environmental, inflammatory, and genotoxic stresses drive the emergence of CH in lung transplant recipients. METHODS We performed a cross-secti
Externí odkaz:
https://doaj.org/article/a83352bd9ffe474699ed8b5770c128f7
Autor:
Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these altera
Externí odkaz:
https://doaj.org/article/16c7679cd4574cb4aab528f73e5a6fc5
Autor:
Francesca Ferraro, Agata Gruszczynska, Marianna B. Ruzinova, Christopher A. Miller, Mary Elizabeth Percival, Geoffrey L. Uy, Iskra Pusic, Meagan A. Jacoby, Mathew J. Christopher, Miriam Y. Kim, Peter Westervelt, Amanda F. Cashen, Mark A. Schroeder, John F. DiPersio, Camille N. Abboud, Lukas D. Wartman, Feng Gao, Daniel C. Link, Timothy J. Ley, John S. Welch
Publikováno v:
Haematologica, Vol 107, Iss 7 (2022)
Externí odkaz:
https://doaj.org/article/a2116fd8e43648e69c98851780c8a622
Autor:
Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and di
Externí odkaz:
https://doaj.org/article/ddf85b9902a447478bc6eb1f3abe22df
Autor:
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Danielle Henley, Stephen Z. Liu, Sergio Barajas, Wenjie Cai, Eric R. Wolf, Baskar Ramdas, Zhigang Cai, Hongyu Gao, Na Luo, Yang Sun, Terrence N. Wong, Daniel C. Link, Yunlong Liu, H. Scott Boswell, Lindsey D. Mayo, Gang Huang, Reuben Kapur, Mervin C. Yoder, Hal E. Broxmeyer, Zhonghua Gao, Yan Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis
Externí odkaz:
https://doaj.org/article/1d5dfae220234a1b8cf7ca069a554a2a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Aging is associated with significant changes in hematopoiesis that include a shift from lymphopoiesis to myelopoiesis and an expansion of phenotypic hematopoietic stem cells (HSCs) with impaired self-renewal capacity and myeloid-skewed lineage differ
Externí odkaz:
https://doaj.org/article/b52fa863a0d24afdb03523bdef428303
Autor:
Grazia Abou-Ezzi, Teerawit Supakorndej, Jingzhu Zhang, Bryan Anthony, Joseph Krambs, Hamza Celik, Darja Karpova, Clarissa S. Craft, Daniel C. Link
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 48-60 (2019)
Summary: Mesenchymal stromal cells are key components of hematopoietic niches in the bone marrow. Here we abrogated transforming growth factor β (TGF-β) signaling in mesenchymal stem/progenitor cells (MSPCs) by deleting Tgfbr2 in mesenchymal cells
Externí odkaz:
https://doaj.org/article/319cb51601434a06ac7c7ad4b0a5f0ac
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000807 (2020)
Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to te
Externí odkaz:
https://doaj.org/article/dfcc01b5a9e84be9b30dca2343479fa0