Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel Burschowsky"'
Autor:
Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Externí odkaz:
https://doaj.org/article/e9b2ccb330b0476b8cb004d93c4045cc
Autor:
Julie Elisabeth Heggelund, Daniel Burschowsky, Victoria Ariel Bjørnestad, Vesna Hodnik, Gregor Anderluh, Ute Krengel
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005567 (2016)
Cholera is the prime example of blood-group-dependent diseases, with individuals of blood group O experiencing the most severe symptoms. The cholera toxin is the main suspect to cause this relationship. We report the high-resolution crystal structure
Externí odkaz:
https://doaj.org/article/680edf2eb5334937ac94a1d2c13eb603
Autor:
Ellen Gowans, Stuart W. Haynes, Mark D. Carr, Stephanie Ryman, Maria A T Groves, Daniel Burschowsky, Tristan J Vaughan, Alexandra Addyman, Vincenzo Cerundolo, Agata Diamandakis, Chitra Seewooruthun, Yoko Shibata, Louise H. Slater, Sarah V. Holt, Denice T Y Chan, Sebastian Fiedler, Jessica Whitehouse, Robert W. Wilkinson, Lesley Jenkinson, Mark Austin, Michelle Barnard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We describe an antibody optimization strategy that seeks to overcome the restrictive nature of existing affinity-maturation methods, by rapidly exploring a vast sequence space in an unbiased manner through application of PCR techniques a
Autor:
Bohdan Waszkowycz, Habiba Begum, Chitra Seewooruthun, Aude Echalier, Amanda J. Watson, Stuart Donald Jones, Richard Bayliss, Mark W. Richards, Rebecca Newton, Li-Ying Lin, Daniel Burschowsky, Allan M. Jordan, Donald J. Ogilvie, Niall M. Hamilton, Samantha Hitchin, Eleanor French, Ian D. Waddell
Publikováno v:
ACS Med Chem Lett
[Image: see text] A combination of focused library and virtual screening, hit expansion, and rational design has resulted in the development of a series of inhibitors of RET(V804M) kinase, the anticipated drug-resistant mutant of RET kinase. These ag
Autor:
Alessandro Rufini, Raquel Palacios Gallego, Cristina Tufarelli, Inna Guterman, Robert G. Britton, Daniel Burschowsky, Lynsey Burke
Publikováno v:
Cell Death Discovery, Vol 6, Iss 1, Pp 1-17 (2020)
Cell Death Discovery
Cell Death Discovery
The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogena
Autor:
Jessica Whitehouse, Mark D. Carr, Lesley Jenkinson, Daniel Burschowsky, Pooja Sharma, Teresa Kaserer, Mark Austin, Yoko Shibata, Michelle Barnard, Sebastian Fiedler, Alexandra Addyman, Denice T Y Chan, Uzi Gileadi, Tristan J Vaughan, Vincenzo Cerundolo, Stuart W. Haynes, Andreas V. Hadjinicolaou, Robert W. Wilkinson, Nadia Luheshi, Ellen Gowans, Stephanie Ryman, Chitra Seewooruthun, Louise H. Slater, Maria A T Groves, Sarah V. Holt, Agata Diamandakis
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Autor:
Ute Krengel, Helene Mykland Hoås, Gertrudis Rojas, Lene Støkken Høydahl, Daniel Burschowsky, Fana Abraha, Julie Elisabeth Heggelund, Paula A. Bousquet, Hedda Johannesen, Noha Abdel-Rahman, Geir Åge Løset, Kaare Bjerregaard-Andersen, Stefan Oscarson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
'Scientific Reports ', vol: 8, pages: 10836-1-10836-11 (2018)
Scientific Reports
'Scientific Reports ', vol: 8, pages: 10836-1-10836-11 (2018)
Scientific Reports
Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen is found in the plasma memb
Publikováno v:
FEBS Open Bio
Chorismate mutase is a well‐known model enzyme, catalyzing the Claisen rearrangement of chorismate to prephenate. Recent high‐resolution crystal structures along the reaction coordinate of this enzyme enabled computational analyses at unprecedent
Autor:
Kathrin Würth-Roderer, Helen Vikdal Thorbjørnsrud, Joel B. Heim, Daniel Burschowsky, Ute Krengel, Jūratė Fahrig-Kamarauskaitė, Peter Kast
Publikováno v:
Biochemistry, 57 (5)
Corynebacterium glutamicum is widely used for the industrial production of amino acids, nucleotides, and vitamins. The shikimate pathway enzymes DAHP synthase (CgDS, Cg2391) and chorismate mutase (CgCM, Cgl0853) play a key role in the biosynthesis of
Autor:
Peter Kast, Alexander Kienhöfer, Donald Hilvert, Mats Ökvist, Ute Krengel, André van Eerde, Daniel Burschowsky
Publikováno v:
Proceedings of the National Academy of Sciences. 111:17516-17521
For more than half a century, transition state theory has provided a useful framework for understanding the origins of enzyme catalysis. As proposed by Pauling, enzymes accelerate chemical reactions by binding transition states tighter than substrate