Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel Broom"'
Aims: Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on evoked withdrawal or reflexive measures. Using a recently developed, anatomically relevant rat model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ee56258cb2869626abc17d8e5cfedc
https://europepmc.org/articles/PMC6492789/
https://europepmc.org/articles/PMC6492789/
Publikováno v:
Pain. 142:59-67
We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund's adjuvant (CFA) to the L4 lumbar spinal nerve as it exits from the intervertebral foramen. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2e6127677873329d8cc07d88b23879
https://doi.org/10.1016/j.pain.2008.11.013
https://doi.org/10.1016/j.pain.2008.11.013
Autor:
Clifford J. Woolf, Roy G. Cutler, Ken Gable, Daniel Broom, Teresa M. Dunn, Andrew Allchorne, Alexander McCampbell, Jeffrey M. Harmon, Matthew P. Frosch, Robert H. Brown, David Truong, Mark P. Mattson
Publikováno v:
Human Molecular Genetics. 14:3507-3521
Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular pathophysiology remain obscure. SPTLC1 encodes one subunit of serine palmitoyltransferase (SPT), the rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a68e94e490a4c1c1ed586f66ca44024
https://doi.org/10.1093/hmg/ddi380
https://doi.org/10.1093/hmg/ddi380
Autor:
Tatsuro Kohno, Clifford J. Woolf, Irmgard Tegeder, Daniel Broom, Tarek A. Samad, Gerd Geisslinger
Publikováno v:
Neuroscience. 124:891-900
Cyclooxygenase-2 (COX-2) after induction peripherally, and within the CNS, plays an important role in producing inflammatory pain. However, its role in neuropathic pain models is controversial. Recently a robust and persistent model of partial nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182337b8adc7933d3fdd78caf4e9f24a
https://doi.org/10.1016/j.neuroscience.2004.01.003
https://doi.org/10.1016/j.neuroscience.2004.01.003
Autor:
Joshua F. Nitsche, James H. Woods, Kenner C. Rice, John R. Traynor, John E. Pintar, Daniel Broom
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:723-729
Delta-opioid receptor-selective agonists produce antinociception and convulsions in several species, including mice. This article examines two hypotheses in mice: 1) that antinociception and convulsive activity are mediated through the same type of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5779c4d3d4cf86b2f0585a9356692cab
https://doi.org/10.1124/jpet.102.036525
https://doi.org/10.1124/jpet.102.036525
Autor:
John R. Traynor, Kenner C. Rice, Emily M. Jutkiewicz, John E. Folk, Daniel Broom, James H. Woods
Publikováno v:
Psychopharmacology. 164:42-48
Rationale. Non-peptidic δ-opioid receptor agonists possess antidepressant-like activity in the forced swim assay in the rat. These compounds have also previously been shown to possess convulsant properties in mice. Objective. The aim of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910c18f3e739b28a0ac93fbd3b055226
https://doi.org/10.1007/s00213-002-1179-y
https://doi.org/10.1007/s00213-002-1179-y
Publikováno v:
Japanese Journal of Pharmacology. 90:1-6
The development of selective delta-opioid receptor agonists has revealed some very intriguing behavioral properties. delta-Opioid agonists have antinociceptive, seizuregenic and convulsive properties. A number of studies have identified a novel behav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295bb8216e16f672bca48ed92f9de15e
https://doi.org/10.1254/jjp.90.1
https://doi.org/10.1254/jjp.90.1
Publikováno v:
Expert opinion on drug discovery. 3(9)
Translating promising analgesic compounds into reliable pain therapeutics in humans is made particularly challenging by the difficulty in measuring the pain quantitatively. This problem is manifest not only in clinical settings in which patient pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4211157500136282fc5a449ae16c1779
https://pubmed.ncbi.nlm.nih.gov/23506182
https://pubmed.ncbi.nlm.nih.gov/23506182
Publikováno v:
Methods in Molecular Biology ISBN: 9781603273220
Creating a robust and unbiased assay for the study of current and novel analgesics has been a daunting task. Traditional rodent models of pain and inflammation typically rely on a negative reaction to various forms of evoked stimuli to elicit a pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65b98c1aacb5bd6570fd67fe8cbbe07
https://doi.org/10.1007/978-1-60327-323-7_6
https://doi.org/10.1007/978-1-60327-323-7_6
Autor:
David J. Matson, Daniel Broom, Michele Matchett, Robin Meade, David J. Wustrow, Marianne E. Buck, Weifeng Yu, Synthia H. Sun, Jun Yuan, Elizabeth Bradshaw, Susan Coombs, Kristen K. Ford, James E. Krause, Daniel N. Cortright, Ricardo Ochoa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 327(3)
Recent evidence suggests that the P2X(7) receptor may play a role in the pathophysiology of preclinical models of pain and inflammation. Therefore, pharmacological agents that target this receptor may potentially have clinical utility as anti-inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d1f744504855c1370ada118e9a3580
https://pubmed.ncbi.nlm.nih.gov/18772321
https://pubmed.ncbi.nlm.nih.gov/18772321