Výsledky vyhledávání - "Daniel Brobst"

Abstract 4470: E-cigarette aerosol exposure increases NF-kB and modulates inflammatory markers in oral epithelial cells

Autor: Vengatesh Ganapathy, Jimmy Manyanga, Dehra McGuire, Daniel Brobst, Balaji Sadhasivam, Mayilvanan Chinnaiyan, Constantin Georgescu, Jonathan Wren, Lurdes Queimado

Publikováno v: Cancer Research. 83:4470-4470

Background: E-cigarette use has skyrocketed among youth, in part because e-cigarettes are perceived as a safer substitute for traditional cigarettes. However, the resulting health effects of e-cigarette use are still unclear. E-cigarette aerosols con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92b486d7aa40fe4240abb8b6a23c94b2
https://doi.org/10.1158/1538-7445.am2023-4470

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Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice

Autor: Chi Wai Lee, Suchaorn Saengnipanthkul, Chun Fai Ng, Wing Suen Chan, Xiuying Yang, Margaret Chui Ling Tse, Keqiang Ye, Jason K. Kim, Hye Lim Noh, Baowei Jiao, Daniel Brobst, Hiu-Lam Rachel Kwan, Oana Herlea-Pana, Brian Pak Shing Pang, Chi Bun Chan, Xinyi Bi, Palak Ahuja, Guanhua Du

Publikováno v: Autophagy

Mitochondrial remodeling is dysregulated in metabolic diseases but the underlying mechanism is not fully understood. We report here that BDNF (brain derived neurotrophic factor) provokes mitochondrial fission and clearance in skeletal muscle via the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c018f48429ed3d889fa1c1324b599418
https://pubmed.ncbi.nlm.nih.gov/34689722

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Abstract 2075: DNA damage on HPRT as a biomarker of susceptibility to tobacco-induced cancer

Autor: Vengatesh Ganapathy, Mayilvanan Chinnaiyan, Sarah E. Johnston, Daniel Brobst, Greg A. Krempl, Daniel Zhao, Lurdes Queimado, Balaji Sadhasivam

Publikováno v: Cancer Research. 81:2075-2075

Background: The prevention of cancer and the development of more effective strategies to detect cancer precursor lesions and early-stage cancers remain critical goals. It has been estimated that 50% - 60% of cancers could be prevented if known strate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::462c9a8f26acf61b2600270d9310c908
https://doi.org/10.1158/1538-7445.am2021-2075

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Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs

Autor: Muna I. Naash, Steven J. Fliesler, Anne R. Murray, Marina S. Gorbatyuk, Daniel Brobst, Muayyad R. Al-Ubaidi, Linda Vuong, Neal S. Peachey

Publikováno v: Human Molecular Genetics. 24:2709-2723

Rhodopsin, a G-protein coupled receptor, most abundant protein in retinal rod photoreceptors, is glycosylated at asparagines-2 and 15 on its N-terminus. To understand the role of rhodopsin's glycosylation in vivo, we generated and characterized a tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2587e274109fcecb5257a80b6c40126
https://doi.org/10.1093/hmg/ddv031

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Fibulin 2, a Tyrosine O-Sulfated Protein, Is Up-regulated Following Retinal Detachment

Autor: Muayyad R. Al-Ubaidi, Zongchao Han, Daniel Brobst, Muna I. Naash, Yogita Kanan

Publikováno v: Journal of Biological Chemistry. 289:13419-13433

Retinal detachment is the physical separation of the retina from the retinal pigment epithelium. It occurs during aging, trauma, or during a variety of retinal disorders such as age-related macular degeneration, diabetic retinopathy, retinopathy of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8746828561054ab6ea83fb423c0c47b2
https://doi.org/10.1074/jbc.m114.562157

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A Systematic Analysis of Predicted Phosphorylation Sites within the Human Pregnane X Receptor Protein

Autor: Jeff L. Staudinger, Kristin Lichti-Kaiser, Chenshu Xu, Daniel Brobst

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 331:65-76

The pregnane X receptor (PXR, NR1I2) regulates the expression of genes that encode drug-metabolizing enzymes and drug transporter proteins in liver and intestine. Understanding the molecular mechanisms that modulate PXR activity is therefore critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df8ccb42383140435b3835c02b2f907
https://doi.org/10.1124/jpet.109.157180

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Abstract 502: Electronic cigarette aerosols increase cellular reactive oxygen species and induce significant oxidative DNA damage

Autor: Theodore L. Wagener, Jimmy Manyanga, Daniel Brobst, Vengatesh Ganapathy, David A. Rubenstein, Lurdes Queimado, Ilangovan Ramachandran, Dehra A. McGuire

Publikováno v: Cancer Research. 77:502-502

Background: E-cigarettes (ECs), also known as electronic nicotine delivery systems (ENDS) are battery-operated devices that deliver nicotine through inhaled aerosols. The health risks associated with EC use are unclear, but ECs have been promoted as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc5c969d501c17828b61252d41c42caf
https://doi.org/10.1158/1538-7445.am2017-502

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p53 selectively regulates developmental apoptosis of rod photoreceptors

Autor: Ivana Ivanovic, Linda Vuong, David M. Sherry, Muayyad R. Al-Ubaidi, Daniel Brobst

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67381 (2013)
PLoS ONE

Retinal cells become post-mitotic early during post-natal development. It is likely that p53, a well-known cell cycle regulator, is involved in regulating the genesis, differentiation and death of retinal cells. Furthermore, retinal cells are under c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40639ef3564ab7c06cdd1f36de374d01
http://europepmc.org/articles/PMC3688626?pdf=render

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