Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel Brian Nichols"'
Autor:
Brian T. Reiss, Lissette Bouza, Swagath Thomas, Catherine D. Suarez, Erik R. Hill, Daniel Brian Nichols
Publikováno v:
Experimental and Molecular Pathology, Vol 134, Iss , Pp 104876- (2023)
Molluscum contagiosum virus (MCV) is a poxvirus that causes benign, persistent skin lesions. MCV encodes a variety of immune evasion molecules to dampen host immune responses. Two of these proteins are the MC159 and MC160 proteins. Both MC159 and MC1
Externí odkaz:
https://doaj.org/article/8e45c7eb03d346918ab84977347bc7af
Publikováno v:
Viruses, Vol 9, Iss 8, p 215 (2017)
Cells have multiple means to induce apoptosis in response to viral infection. Poxviruses must prevent activation of cellular apoptosis to ensure successful replication. These viruses devote a substantial portion of their genome to immune evasion. Man
Externí odkaz:
https://doaj.org/article/1055bcdd0a48451d8c7ef4e5af631c77
Autor:
Jessica Cottrell, Joachim Jakob Bugert, Daniel Brian Nichols, Timothy Iversen, William De Martini, Jesse Coutu
Publikováno v:
Future Virology. 14:319-333
Aim: The molluscum contagiosum virus (MCV) expresses several immune evasion molecules that inhibit activation of NF-κB. Presumably, inhibition of inflammatory responses mediated by NF-κB allows MCV to cause persistent infections. Materials & method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3814d49ba523209c8e814537b8dc6117
https://doi.org/10.2217/fvl-2019-0018
https://doi.org/10.2217/fvl-2019-0018
Autor:
Tanaji T. Talele, Uday Kiran Velagapudi, Sarah Weber, Michael W. Beaury, Daniel Brian Nichols, Cassandra Soto
Publikováno v:
Virus Genes. 53:522-531
The molluscum contagiosum virus (MCV) uses a variety of immune evasion strategies to antagonize host immune responses. Two MCV proteins, MC159 and MC160, contain tandem death effector domains (DEDs). They are reported to inhibit innate immune signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bdfadc2532686c2ccba09a76e9fd60
https://doi.org/10.1007/s11262-017-1456-9
https://doi.org/10.1007/s11262-017-1456-9
Autor:
Geoffrey J. Clark, Daniel Brian Nichols, Diego F. Calvisi, Neerja Kaushik-Basu, Howard Donninger, M. Lee Schmidt, Amartya Basu, Payal Arora
Publikováno v:
Hepatology. 65:1462-1477
Hepatitis C virus (HCV) infection is a common risk factor for the development of liver cancer. The molecular mechanisms underlying this effect are only partially understood. Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee136c8bcbe00c002079c4062a4ed1e
https://doi.org/10.1002/hep.29049
https://doi.org/10.1002/hep.29049
Autor:
Paulo R. R. Costa, Talita de A. Fernandes, Dinesh Manvar, Amartya Basu, Jorge L.O. Domingos, Daniel Brian Nichols, Neerja Kaushik-Basu
Publikováno v:
European Journal of Medicinal Chemistry. 112:33-38
The synthesis of a series of 5-carba-pterocarpens derivatives involving the cyclization of α-aryl-α-tetralones is described. Several compounds demonstrated potent activity and selectivity in vitro against HCV replicon reporter cells. The best profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4cb7cce8be185377f5972956ba7513
https://doi.org/10.1016/j.ejmech.2016.02.010
https://doi.org/10.1016/j.ejmech.2016.02.010
Autor:
Tanaji T. Talele, K.R. Gurukumar, İlkay Küçükgüzel, Daniel Brian Nichols, Esra Tatar, Amartya Basu, Neerja Kaushik-Basu, Gökhan Satılmış
Publikováno v:
European Journal of Medicinal Chemistry. 69:931-941
Hepatitis C virus (HCV) NS5B polymerase is an important and attractive target for the development of anti-HCV drugs. Here we report on the design, synthesis and evaluation of twenty-four novel allosteric inhibitors bearing the 4-thiazolidinone scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e067b5691994061a413ddd1c699e6d
https://doi.org/10.1016/j.ejmech.2013.08.043
https://doi.org/10.1016/j.ejmech.2013.08.043
Autor:
Payal Arora, Neerja Kaushik-Basu, Sevil Aydin, Orhan Büyükgüngör, Daniel Brian Nichols, Amartya Basu, Tanaji T. Talele, Ísmail Çelik, Mehmet Akkurt, Ş. Güniz Küçükgüzel
Publikováno v:
MARMARA PHARMACEUTCAL JOURNAL. 1:26-34
The synthesis of a new series of flurbiprofen hydrazide-hydrazones using microwave assisted reactions is described. Substituted aldehydes were condensed with flurbiprofen hydrazide by microwave irradiation to corresponding hydrazones. Synthesis of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d522716b977c1b3a566a346069cc09
https://doi.org/10.12991/201317389
https://doi.org/10.12991/201317389
Autor:
K.R. Gurukumar, Amartya Basu, Jin-Ching Lee, Andriy G. Golub, Tanaji T. Talele, Volodymyr G. Bdzhola, Sergiy M. Yarmoluk, Daniel Brian Nichols, Neerja Kaushik-Basu, Yaroslav V. Bilokin
Publikováno v:
European Journal of Medicinal Chemistry. 58:258-264
Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of anti-HCV drugs. Here we report on the identification of novel allosteric inhibitors of HCV NS5B through a combination of structure-based virtual screening and in vitro NS5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e254ba59234817d21f911b4e61a0f0
https://doi.org/10.1016/j.ejmech.2012.09.010
https://doi.org/10.1016/j.ejmech.2012.09.010
Publikováno v:
Virology. 505
Apoptosis is a powerful host cell defense to prevent viruses from completing replication. Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460452122bed1f9cb4575360464fc367
https://pubmed.ncbi.nlm.nih.gov/28235685
https://pubmed.ncbi.nlm.nih.gov/28235685