The pH-dependent distribution of the photosensitizer chlorin e6 among plasma proteins and membranes: A physico-chemical approach

Autor: Halina Mojzisova, Christine Vever-Bizet, Stéphanie Bonneau, Daniel Brault

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2007, 1768 (2), pp.366-374
Biochimica et Biophysica Acta:Biomembranes, 2007, 1768 (2), pp.366-374

Decrease in interstitial pH of the tumor stroma and over-expression of low density lipoprotein (LDL) receptors by several types of neoplastic cells have been suggested to be important determinants of selective retention of photosensitizers by prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a081599fcaf80c2d659aa3efbce9982

Investigation of singlet oxygen reactivity towards propofol

Autor: Stephan Kohnen, Daniel Brault, F. Tfibel, Pol Hans, Belinda Heyne, Ange Mouithys-Mickalad, Marie-Pierre Fontaine-Aupart, Maryse Hoebeke

Publikováno v: Photochemical & Photobiological Sciences. 2:939-945

The reaction between the anaesthetic agent 2,6-diisopropylphenol (propofol, PPF) and singlet oxygen (1O2) has been investigated in aqueous solution by means of HPLC, GC, absorption spectroscopy and laser flash photolysis with infrared luminescence de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264e0c528f3b29d4c0fa7088ba2e6c71
https://doi.org/10.1039/b302373g

Kinetics of the interactions of a dicarboxylic porphyrin with unilamellar lipidic vesicles: Interplay between bilayer thickness and pH in rate control

Autor: Daniel Brault, Nathalie Maman

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1414:31-42

The transfer of a dicarboxylic porphyrin from phosphatidylcholine fluid-phase unilamellar vesicles towards albumin is studied focusing on bilayer thickness and pH effects. The kinetics of this process yield the rate constants for the porphyrin flip-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5411cbbb950522a0fb9849cec63b5d3
https://doi.org/10.1016/s0005-2736(98)00149-7

Chlorin-Oligonucleotide Conjugates: Synthesis, Properties, and Red Light-Induced Photochemical Sequence-Specific DNA Cleavage in Duplexes and Triplexes

Autor: Daniel Brault, Alexandre S. Boutorine, Masashi Takasugi, Olavio Delgado, Claude Hélène

Publikováno v: Journal of the American Chemical Society. 118:9469-9476

Conjugates of oligonucleotides with chlorin-type photosensitizers were prepared. Two chlorin moieties, CPP and CHEVP, characterized by a modified pyrrole unit bearing an aldehyde chain, were photochemically prepared from protoporphyrin and heptaethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe21dbc0ec9250af4541af3643865b2
https://doi.org/10.1021/ja960062i

Reaction of the m-THPC triplet state with the antioxidant Trolox and the anesthetic Propofol: modulation of photosensitization mechanisms relevant to photodynamic therapy?

Autor: Daniel Brault, O. Friaa, Philippe Maillard

Publikováno v: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 11(4)

Antioxidants may affect the outcome of photodynamic therapy (PDT) through the inactivation of reactive oxygen species. Their direct interaction with photosensitizers excited at the triplet state is also worthy of interest. This process is investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a37fba6c238f435796abf1dd187365
https://pubmed.ncbi.nlm.nih.gov/22307091