Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Daniel Brandhorst"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present study was aimed to assess the effect
Externí odkaz:
https://doaj.org/article/b41a0d285bae4a7c966ca4bef69d2c1c
Autor:
Heide Brandhorst, Daniel Brandhorst, Anju Abraham, Samuel Acreman, Simen W. Schive, Hanne Scholz, Paul R.V. Johnson
Publikováno v:
Cell Transplantation, Vol 29 (2020)
Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have confirmed these findings but have not determined whet
Externí odkaz:
https://doaj.org/article/f2ecfb862b264ea0b309c7e238346e38
Autor:
Heide Brandhorst, Paul R. Johnson, Johanna Mönch, Manfred Kurfürst, Olle Korsgren, Daniel Brandhorst
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Although human islet transplantation has been established as valid and safe treatment for patients with type 1 diabetes, the utilization rates of human pancreases for clinical islet transplantation are still limited and substantially determined by th
Externí odkaz:
https://doaj.org/article/c35122ab7dff423d93af7ce21267ac08
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Efficient islet release from the pancreas requires the combination of collagenase, neutral protease (cNP), or thermolysin (TL). Recently, it has been shown that clostripain (CP) may also contribute to efficient islet release from the human pancreas.
Externí odkaz:
https://doaj.org/article/a97a0609a26442ef9eda70c0e7482c2c
Autor:
Daniel Brandhorst, Géraldine Parnaud, Andrew Friberg, Vanessa Lavallard, Sandrine Demuylder-Mischler, Stephen Hughes, Julia Saphörster, Manfred Kurfürst, Olle Korsgren, Thierry Berney, Paul R. V. Johnson
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Animal-free (AF) SERVA Collagenase AF-1 and Neutral Protease (NP) AF GMP Grade have recently become available for human islet isolation. This report describes the initial experiences of 3 different islet transplant centers. Thirty-four human pancreas
Externí odkaz:
https://doaj.org/article/b3c2324601ed460886948968e4bb0bbd
Autor:
Magnus Ståhle, Aksel Foss, Bengt Gustafsson, Marko Lempinen, Torbjörn Lundgren, Ehab Rafael, Gunnar Tufveson, Bastian Theisinger, Daniel Brandhorst, Olle Korsgren, Andrew Friberg
Publikováno v:
Cell Transplantation, Vol 25 (2016)
This study aimed to evaluate a 50:50 mix of perfluorohexyloctane/polydimethylsiloxane 5 (F6H8S5) preservation of pancreases in a clinical setting compared with standard solutions for 1) cold ischemia time (CIT) 20 h. Procured clinical-grade pancrease
Externí odkaz:
https://doaj.org/article/1df7510626ad4b42a4c783e66ef43491
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model
Externí odkaz:
https://doaj.org/article/b347001576fd4529ab253b32adaed111
Publikováno v:
Cell Transplantation, Vol 25 (2016)
The isolation and transplantation of porcine islets represent a future option for the treatment of type 1 diabetic patients. Stringent product release criteria and limited availability of transgenic and specific pathogen-free pigs will essentially re
Externí odkaz:
https://doaj.org/article/e8cb303b27114c9cbea14160e23c7b48
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Serum is regarded as an essential supplement to promote survival and growth of cells during culture. However, the potential risk of transmitting diseases disqualifies the use of serum for clinical cell therapy in most countries. Hence, most clinical
Externí odkaz:
https://doaj.org/article/56f00c4f51c74f9793333160e8ba27df
Autor:
Daniel Brandhorst, Vidya Kumarasamy, Adel Maatoui, Alexandra Alt, Reinhard G. Bretzel, Heide Brandhorst
Publikováno v:
Cell Transplantation, Vol 15 (2006)
During the isolation procedure and after transplantation islets are subjected to numerous variables associated with the induction of apoptosis. The present study investigated the effect of transient pretreatment with caspase inhibitors on function an
Externí odkaz:
https://doaj.org/article/13149040483647e9aec9974b8d16e476