Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daniel Bonhenry"'
Autor:
Matthias Sallinger, Adéla Tiffner, Tony Schmidt, Daniel Bonhenry, Linda Waldherr, Irene Frischauf, Victoria Lunz, Isabella Derler, Romana Schober, Rainer Schindl
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4410 (2020)
Stromal interaction molecule 1 (STIM1) is a ubiquitously expressed Ca2+ sensor protein that induces permeation of Orai Ca2+ channels upon endoplasmic reticulum Ca2+-store depletion. A drop in luminal Ca2+ causes partial unfolding of the N-terminal ST
Externí odkaz:
https://doaj.org/article/fb9d8fc255c8464eb92a6f2a72999084
Autor:
Matthias Sallinger, Herwig Grabmayr, Christina Humer, Daniel Bonhenry, Christoph Romanin, Rainer Schindl, Isabella Derler
Publikováno v:
The Journal of Physiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d2a722a687ba2d2c7f0807e28880ca
https://doi.org/10.1113/jp283828
https://doi.org/10.1113/jp283828
Autor:
Katja Ester, Marija Mioč, Pavel Spurny, Daniel Bonhenry, Marko Marjanović, Lidija Uzelac, Jelena Gabrilo, Tatjana Šumanovac, Wolfgang Schreibmayer, Kata Majerski, Babak Minofar, Jost Ludwig, Marijeta Kralj
The adamantane derived diaza-crown ether ZG613 was assessed as a potential breast cancer cells and breast epithelial to mesenchymal transition (EMT)-model cells targeting agent. We postulated that ZG613 activity relies on its plasma/mitochondria memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0c2a873ddc7d0e56862196190b81e6
https://doi.org/10.1101/2022.09.30.510273
https://doi.org/10.1101/2022.09.30.510273
Autor:
Linda Waldherr, Adela Tiffner, Deepti Mishra, Matthias Sallinger, Romana Schober, Irene Frischauf, Tony Schmidt, Verena Handl, Peter Sagmeister, Manuel Köckinger, Isabella Derler, Muammer Üçal, Daniel Bonhenry, Silke Patz, Rainer Schindl
Publikováno v:
Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2876, p 2876 (2020)
Volume 12
Issue 10
Cancers, Vol 12, Iss 2876, p 2876 (2020)
The Ca2+ sensor STIM1 and the Ca2+ channel Orai1 that form the store-operated Ca2+ (SOC) channel complex are key targets for drug development. Selective SOC inhibitors are currently undergoing clinical evaluation for the treatment of auto-immune and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::99b1cd36bc06f87a37b9eaa53c1546ca
Autor:
Sonja Lindinger, Saurabh Pandey, Adéla Tiffner, Isabella Derler, Michael Stadlbauer, Victoria Lunz, Daniel Bonhenry, Rudi Ettrich, Irene Frischauf, Matthias Sallinger, Marc Fahrner, Christoph Romanin, Lena Maltan, Sascha Berlansky, Rainer Schindl, Romana Schober, Carmen Hoeglinger
The initial activation step in gating of ubiquitously expressed Orai1 Calcium (Ca2+) ion channels represents the store-dependent coupling to the Ca2+ sensor protein STIM1. An array of constitutively active Orai1 mutants gave rise to the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a605ab39dd19a2e1115dfd3781cef8
https://doi.org/10.1101/2020.07.16.207183
https://doi.org/10.1101/2020.07.16.207183
Autor:
Romana, Schober, Daniel, Bonhenry, Victoria, Lunz, Jinhui, Zhu, Adela, Krizova, Irene, Frischauf, Marc, Fahrner, MengQi, Zhang, Linda, Waldherr, Tony, Schmidt, Isabella, Derler, Peter B, Stathopulos, Christoph, Romanin, Rüdiger H, Ettrich, Rainer, Schindl
Publikováno v:
Science signaling. 12(608)
The stromal interaction molecule 1 (STIM1) has two important functions, Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::335f671397e3f1d355e70d4f9b13bf3c
https://pubmed.ncbi.nlm.nih.gov/31744929
https://pubmed.ncbi.nlm.nih.gov/31744929
Autor:
Rüdiger Ettrich, Irene Frischauf, Rainer Schindl, Linda Waldherr, Adéla Krizova, MengQi Zhang, Tony Schmidt, Isabella Derler, Jinhui Zhu, Romana Schober, Christoph Romanin, Victoria Lunz, Marc Fahrner, Peter B. Stathopulos, Daniel Bonhenry
Publikováno v:
Science Signaling. 12
The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. We combined molecular dynamics (MD) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63eacb72fe814547ba462748f041ce63
https://doi.org/10.1126/scisignal.aax3194
https://doi.org/10.1126/scisignal.aax3194
Publikováno v:
Biomolecular Simulations in Structure-Based Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b4bd13747ab53cb9b273f219366a053
https://doi.org/10.1002/9783527806836.ch10
https://doi.org/10.1002/9783527806836.ch10
Publikováno v:
eLife
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4503355606412d048cd51c4a1f5e99
https://doi.org/10.1016/j.ceca.2020.102323
https://doi.org/10.1016/j.ceca.2020.102323
Autor:
Daniel Bonhenry, Tony Schmidt, Rainer Schindl, Romana Schober, Linda Waldherr, Rüdiger Ettrich
Publikováno v:
Seminars in celldevelopmental biology. 94
Highly Ca2+ selective channels trigger a large variety of cellular signaling processes in both excitable and non-excitable cells. Among these channels, the Orai channel is unique in its activation mechanism and its structure. It mediates Ca2+ influx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c360e5f25e23514f2a81e77cf29415
https://pubmed.ncbi.nlm.nih.gov/30639326
https://pubmed.ncbi.nlm.nih.gov/30639326