Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Daniel Blount"'
Autor:
Andrew Godkin, Awen Gallimore, Robert Hills, Richard Harrop, Daniel Blount, Sarah Gwynne, Robert Jones, Alison Brewster, Richard Adams, Hayley Bridgeman, Kathryn Smart, Amanda Thomson, David Roberts, Anja Bloom, Tom Pembroke, Martin Scurr
Purpose: Anticancer T-cell responses can control tumors, but immunosuppressive mechanisms in vivo prevent their function. The role of regulatory T cells (Tregs) in metastatic colorectal cancer is unclear. We have previously shown depletion of Tregs e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1f48485911346057d5a28de4595efc
https://doi.org/10.1158/1078-0432.c.6525245
https://doi.org/10.1158/1078-0432.c.6525245
Autor:
Andrew Godkin, Awen Gallimore, Robert Hills, Richard Harrop, Daniel Blount, Sarah Gwynne, Robert Jones, Alison Brewster, Richard Adams, Hayley Bridgeman, Kathryn Smart, Amanda Thomson, David Roberts, Anja Bloom, Tom Pembroke, Martin Scurr
Supplementary Figure 1. CONSORT diagram. Supplementary Figure 2. 5T4 peptide pools and matrix system. Supplementary Figure 3. B-cell number in response to cyclophosphamide. Supplementary Figure 4. Expression of activation markers in T-cell subsets du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccf646f32661490d9797c502cb70e8a
https://doi.org/10.1158/1078-0432.22462886.v1
https://doi.org/10.1158/1078-0432.22462886.v1
Autor:
Gurdeep Kooner, Richard J. Edmondson, Eleanor J. Cheadle, Gemma L Owens, Victoria Sheard, Richard Harrop, David E. Gilham, Yatish Lad, Daniel Blount, Milena Kalaitsidou
Publikováno v:
Owens, G, Edmondson, R & Cheadle, E 2018, ' Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer ', Journal of Immunotherapy, vol. 41, no. 3, pp. 130-140 . https://doi.org/10.1097/CJI.0000000000000203
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Supplemental Digital Content is available in the text.
Chimeric antigen receptor (CAR) T cells represent a novel targeted approach to overcome both quantitative and qualitative shortfalls of the host immune system relating to the detection and s
Chimeric antigen receptor (CAR) T cells represent a novel targeted approach to overcome both quantitative and qualitative shortfalls of the host immune system relating to the detection and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5badf1da0c0cbcfd4e64e99fa8b0ac
https://doi.org/10.1097/cji.0000000000000203
https://doi.org/10.1097/cji.0000000000000203
Publikováno v:
Cancer Immunology, Immunotherapy. 62:1511-1520
The attenuated vaccinia virus, modified vaccinia Ankara, has been engineered to deliver the tumor antigen 5T4 (TroVax®). Here, we report results from a randomized open-label phase II trial in castration-resistant prostate cancer patients in which Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497e9d878e45ee197dd76976cb07cad5
https://doi.org/10.1007/s00262-013-1457-z
https://doi.org/10.1007/s00262-013-1457-z
Autor:
Robert H. Jones, Awen Gallimore, Andrew James Godkin, Daniel Blount, Sarah Gwynne, Robert Kerrin Hills, Richard Adams, Richard Harrop, Tom Pembroke, Alison Brewster, Martin J. Scurr
Publikováno v:
Journal of Clinical Oncology. 35:154-154
154 Background: Current immunotherapies including checkpoint inhibitors and vaccines for advanced colorectal cancer (CRC) have been largely ineffective. We hypothesized that combining an MVA-based vaccine targeting the tumor-associated antigen 5T4 (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbfe71c63cd563c6a85d805f6b48e0b
https://doi.org/10.1200/jco.2017.35.7_suppl.154
https://doi.org/10.1200/jco.2017.35.7_suppl.154