Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel Blackstock"'
Autor:
Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O’Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, Q. Paula Lei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a post-translational modification, was known to play a key role for antibody b
Externí odkaz:
https://doaj.org/article/92e48070fe3244d88988a4135f9f4025
Autor:
Kirsten E Lyke, Andrea A Berry, Kaitlin Mason, Azza H Idris, Mark O'Callahan, Myra Happe, Larisa Strom, Nina M Berkowitz, Mercy Guech, Zonghui Hu, Mike Castro, Manjula Basappa, Lu Wang, Kwang Low, LaSonji A Holman, Floreliz Mendoza, Ingelise J Gordon, Sarah H Plummer, Olga Trofymenko, Kathleen S Strauss, Sudhaunshu Joshi, Biraj Shrestha, Matthew Adams, Andrezza Campos Chagas, Jittawadee R Murphy, Judy Stein, Somia Hickman, Andrew McDougal, Bob Lin, Sandeep R Narpala, Sandra Vazquez, Leonid Serebryannyy, Adrian McDermott, Martin R Gaudinski, Edmund V Capparelli, Emily E Coates, Richard L Wu, Julie E Ledgerwood, Lesia K Dropulic, Robert A Seder, Cheryl Young, Colleen Boyce, Jennifer Winkler, Susan Holian, Nancy Greenberg, Shirley George, Alyson Kwon, Brenda Dorsey, Ana Raquel Da Costa, William Witt, Daryl Grays, Arren Gapasin, Paula Bernal, Jeffrey Floyd, Eric Goldstein, Leslie Howe, Myounghee Lee, Jennifer Marron, Kelly Brooks, Lisa Turek, Patricia Farley, Shantel Frels, Delores Booth, Jason Gall, Kevin Carlton, Gabriela Albright, Nadia Amharref, Kandace Atallah, Sashikanth Banappagari, Niutish Bastani, Daniel Blackstock, Bobby Boonyaratanakornkit, Elizabeth Carey, Adam Charlton, Rajoshi Chaudhuri, Alegria M. Caringal, Mingzhong Chen, Peifeng Chen, Wei Cheng, Daniel Gowetski, Krishana Gulla, Erica Hastings, Joe Horwitz, Vera Ivleva, Dan Kordella, Lisa A. Kueltzo, Sara Lagler, Matt Le, James Lee, Paula Lei, Yile Li, Attila Nagy, Aakash Patel, Peyi Runsewe, Will Shadrick, Shamitha Shetty, Hairong Wang, Calvin Webber, Farah Vejzagic, Yoo-Jung Yang
Publikováno v:
The Lancet Infectious Diseases. 23:578-588
Autor:
null Deepika Gollapudi, null Erwin Rosales‐Zavala, null Vera B. Ivleva, null Yanhong Yang, null Yile Li, null Sarah O'Connell, null Nicole A. Doria‐Rose, null Aakash Patel, null Daniel Blackstock, null Daniel B. Gowetski, null Kevin Carlton, null Jason G. D. Gall, null Q. Paula Lei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ae8e189d46884d3d14430fca32dba0
https://doi.org/10.1002/btpr.3296/v2/response1
https://doi.org/10.1002/btpr.3296/v2/response1
Autor:
Deepika Gollapudi, Erwin Rosales‐Zavala, Vera B. Ivleva, Yanhong Yang, Yile Li, Sarah O'Connell, Nicole A. Doria‐Rose, Aakash Patel, Daniel Blackstock, Daniel B. Gowetski, Kevin Carlton, Jason G. D. Gall, Q. Paula Lei
Publikováno v:
Biotechnology progressREFERENCES. 38(6)
Broadly neutralizing antibody (bNAb) CAP256-VRC26.25 (abbreviated CAP256LS), a human IgGI monoclonal antibody targeting the V1V2 site of the HIV-1 envelope, has demonstrated high therapeutic potential as a broadly neutralizing monoclonal antibody aga
Autor:
Q. Paula Lei, Nicole A. Schneck, Cindy X. Cai, Adam Charlton, Vera B. Ivleva, K. C. Cheng, Frank J. Arnold, Jonathan W. Cooper, Daniel Blackstock, Doug Harris
Publikováno v:
J Chromatogr B Analyt Technol Biomed Life Sci
During research of a broadly neutralizing antibody (bNAb) for HIV-1 infection, site-specific clipping was observed during cell culture incubation. Protease inhibitor, 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF), was supplemented to the cell cul
Autor:
Jesse L. Huang, Cindy X. Cai, Attila Nagy, Vera B. Ivleva, Frank J. Arnold, Daniel Blackstock
Publikováno v:
Analytical Chemistry. 90:4293-4296
One approach to mitigate product clipping during HIV mAb CAP256-VRC26.25 cell-culture development is the addition of the protease inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF) to the cell-culture media. AEBSF can undergo hydrolysis to f
Autor:
Jinsung Hong, Joe Horwitz, James J. Lee, Jacob Demirji, Tracey Dinh, Alvenne Goh, Frank J. Arnold, Daniel Blackstock
Publikováno v:
Biotechnology Progress. 35
An alternating tangential flow (ATF) perfusion-based transient gene expression (TGE) bioprocess has been developed using human embryonic kidney (HEK) 293 cells to produce H1-ss-np, a promising candidate for a universal influenza vaccine. Two major ad
Publikováno v:
ACS Nano. 9:8554-8561
Context driven biosensor assembly with modular targeting and detection moieties is gaining significant attentions. Although protein-based nanoparticles have emerged as an excellent platform for biosensor assembly, current strategies of decorating bio
Publikováno v:
Biotechnology and Bioengineering. 112:236-241
Molecular beacons (MBs) are stem-loop structured oligonucleotides capable of sensitive and specific nucleic acid detection. However, large-scale usage of MBs for high throughput applications has been hindered by the many expensive and tedious chemica
Publikováno v:
Current Opinion in Chemical Engineering. 2:416-424
Proteins that communicate a biological event (either ligand binding, enzymatic modification, or protease cleavage) into a measurable output are highly desirable for diagnostic applications. Since many biological functions are naturally regulated usin