Výsledky vyhledávání - "Daniel Belmont"

A novel asymmetric synthesis of tritium and carbon-14 labeled (R)-ibuprofen

Autor: Yang Hong, Che C. Huang, Daniel Belmont, Yinsheng Zhang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 49:237-244

An efficient asymmetric synthesis of tritium and carbon-14 labeled R-ibuprofen was achieved in good overall yield (15% and 47%, respectively) and excellent enantiomerical excess (>98% e.e.), using (4R, 5S)-4-methyl-5-phenyl-2-oxazolidinone as a chira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ef88948d341eb7e91476a3e3431659
https://doi.org/10.1002/jlcr.1040

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Mucohalic acid in Lewis acid catalyzed Mukaiyama aldol reaction: a concise method for highly functionalized γ-substituted γ-butenolides

Autor: Daniel Belmont, James G. Davidson, Ji Zhang, Timothy T. Curran, Paul Angell

Publikováno v: Tetrahedron Letters. 46:2029-2032

The first Mukaiyama aldol reaction on mucohalic acid ( 1a / b ) has been achieved. Reaction of 1 with various ketene silyl acetals or silyl enol ethers in the presence of a Lewis acid provides the γ-substituted γ-butenolides in good to excellent yi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b929ce7c5ba87ebb75729c933d03e454
https://doi.org/10.1016/j.tetlet.2005.01.147

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Development of a Scalable Process for CI-1034, an Endothelin Antagonist

Autor: Kanter Gerald David, James J. Krikke, Thomas Elliott Jacks, Skeean Richard, Nicole Marcia Horne, Christopher A. Briggs, Thomas Zennie, Greg L. Karrick, Thomas Norman Nanninga, Daniel Belmont, Jason Mustakis, Guy S. Risedorph, Derick Dale Winkle, Mccabe Richard Joseph, Ronald E. Seamans

Publikováno v: Organic Process Research & Development. 8:201-212

A concise, convergent multikilogram synthesis of CI-1034 (1), a potent endothelin receptor antagonist, is described. A 15-step preparation from commercially available o-vanillin and benzenesulfonyl chloride employs a remarkably robust Suzuki coupling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b54b726d74acd6d06240c400aa0bcc40
https://doi.org/10.1021/op034104g

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Metal-mediated allylation of mucohalic acids: facile formation of γ-allylic α,β-unsaturated γ-butyrolactones

Autor: Ji Zhang, Heidi Berven, Daniel Belmont, Peter G. Blazecka

Publikováno v: Tetrahedron Letters. 44:5579-5582

Mucohalic acids {mucochloric acid ( 1 , 3,4-dichloro-5-hydroxy-5 H -furan-2-one and mucobromic acid ( 2 , 3,4-dibromo-5-hydroxy-5 H -furan-2-one)} were employed as aldehydes in the indium- and tin-mediated Barbier-type allylation reactions and afford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6258df44da08e63713fa4972117dc23
https://doi.org/10.1016/s0040-4039(03)01380-7

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Practical Alternative Synthesis of 1-(8-Fluoro-naphthalen-1-yl)piperazine

Autor: Zhijian Zhu, Jerry D. Clark, Norm L. Colbry, Alison Acciacca, Mark Lovdahl, Vladimir Beylin, Kenneth E. Mennen, Daniel Belmont

Publikováno v: Organic Process Research & Development. 11:907-909

Convergent synthesis of 8-fluoronaphthalen-1-ylamine (6) was achieved through the reaction of 1H-naphtho[1,8-de][1,2,3]triazine (15) with HF-pyridine under mild conditions. This new synthesis for the preparation of 6 overcame many scale-up challenges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b31095eacbe9a78257732ebb7ae1e65b
https://doi.org/10.1021/op7001535

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Efficient synthesis of novel gamma-substituted gamma-butenolides by Lewis acid catalyzed addition of metal enolates of active methylene compounds to mucohalic acids

Autor: Timothy T. Curran, Ji Zhang, Daniel Belmont, Koushik Das Sarma, James G. Davidson

Publikováno v: The Journal of organic chemistry. 70(15)

Lewis acid catalyzed addition of active methylene compounds to mucochloric acid (1) and mucobromic acid (2) affording Knoevenagel aldol adducts, gamma-substituted gamma-butenolides, has been explored. Catalytic efficiencies of various Lewis acids hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35576598b96892ca9cb858e35b539282
https://pubmed.ncbi.nlm.nih.gov/16018682

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Further Utilization of Mucohalic Acids: Palladium-Free, Regioselective Etherification and Amination of α,β-Dihalo γ-Methoxycarbonyloxy and γ-Acetoxy Butenolides

Autor: Ji Zhang, Timothy T. Curran, Derek A. Pflum, Peter G. Blazecka, Daniel Belmont

Publikováno v: ChemInform. 35

Palladium-free etherification and amination of mucohalic acid methyl carbonates 1e (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855543f1747d21b562e52a4015bddd24
https://doi.org/10.1002/chin.200418085

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Reinvestigation of Mucohalic Acids, Versatile and Useful Building Blocks for Highly Functionalized α,β-Unsaturated γ-Butyrolactones

Autor: Daniel Belmont, Peter G. Blazecka, Ji Zhang, James G. Davidson

Publikováno v: ChemInform. 34

[reaction: see text] Mucohalic acids (mucochloric acid (1, 3,4-dichloro-5-hydroxy-5H-furan-2-one) and mucobromic acid (2, 3,4-dibromo-5-hydroxy-5H-furan-2-one)) are inexpensive, commercially available starting materials with multiple functional group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b90714ca9c80bed586cc8c6ed53918
https://doi.org/10.1002/chin.200317096

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