Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel Bassoni"'
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ef2bc82d233c0d9b892e9b438b69b2
https://doi.org/10.1096/fasebj.2021.35.s1.03045
https://doi.org/10.1096/fasebj.2021.35.s1.03045
Publikováno v:
Cellular and Molecular Neurobiology. 41:1075-1075
The biased signaling has been extensively studied in the original mu opioid receptor (MOR-1), particularly through G protein and β-arrestin2 signaling pathways. The concept that the G protein pathway is often linked to the therapeutic effect of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9a131f21ef42a5477395cb4d0f69ce
https://doi.org/10.1007/s10571-020-00990-4
https://doi.org/10.1007/s10571-020-00990-4
Autor:
Becky Hood, Danielle McAnally, Andras Szabo, Haleli Sharir, Stefan Vasile, Camilo J. Morfa, Layton H. Smith, Tom S. Wehrman, Jane Lamerdin, Daniel Bassoni
Publikováno v:
Assay and drug development technologies. 16(7)
G-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides, and mechanical forces. More than 130 GPCRs are orphan receptors (i.e., their endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9525d94bff6aec9def90f33a901a6446
https://pubmed.ncbi.nlm.nih.gov/30251873
https://pubmed.ncbi.nlm.nih.gov/30251873
Autor:
Jonathan O’Connell, Molly R. Ryan, Marta Filizola, Tom S. Wehrman, Daniel Bassoni, Neil T. Burford, Martyn Banks, Yi Shang, Andrew Alt, Samuel Gerritz, Kathryn E. Livingston, Lauren Budenholzer, John R. Traynor, John J. Herbst, Litao Zhang, Arthur Christopoulos, Ying Han, Meritxell Canals
Allosteric modulators of G protein-coupled receptors (GPCRs) have a number of potential advantages compared to agonists or antagonists that bind to the orthosteric site of the receptor. These include the potential for receptor selectivity, maintenanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c185e7de02206a5d1a7ec518591e52aa
https://europepmc.org/articles/PMC4703104/
https://europepmc.org/articles/PMC4703104/
Autor:
Tom S. Wehrman, Jonathan O’Connell, Daniel Bassoni, Martyn Banks, Neil T. Burford, Andrew Alt, Litao Zhang
Publikováno v:
Journal of biomolecular screening. 19(9)
Hetero-oligomeric complexes of G protein–coupled receptors (GPCRs) may represent novel therapeutic targets exhibiting different pharmacology and tissue- or cell-specific site of action compared with receptor monomers or homo-oligomers. An ideal too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8287bbde1f6bbf9a9b1cf6ea4609a96
https://pubmed.ncbi.nlm.nih.gov/25047277
https://pubmed.ncbi.nlm.nih.gov/25047277
Autor:
Tom S. Wehrman, James Campbell, Sudarshan Rajagopal, Daniel Bassoni, Craig Gerard, Norma P. Gerard
Publikováno v:
The FASEB Journal. 28
Chemokines display considerable promiscuity with multiple ligands and receptors shared in common. Their receptors are G protein-coupled receptors (GPCRs), which are capable of signaling with differ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9802bda8a482aadb71d0dcf8a6e50596
https://doi.org/10.1096/fasebj.28.1_supplement.1066.17
https://doi.org/10.1096/fasebj.28.1_supplement.1066.17
Autor:
Craig Gerard, Daniel Bassoni, James Campbell, Norma P. Gerard, Sudarshan Rajagopal, Tom S. Wehrman
Chemokines display considerable promiscuity with multiple ligands and receptors shared in common, a phenomenon that is thought to underlie their biochemical "redundancy." Their receptors are part of a larger seven-transmembrane receptor superfamily,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beff246b267a2873a5d8c1315585e848
https://europepmc.org/articles/PMC3853256/
https://europepmc.org/articles/PMC3853256/
Autor:
Craig Southern, Daniel Bassoni, Debra Taylor, Anthony P. Davenport, Andy Merritt, Tom S. Wehrman, Jennifer M. Cook, William Raab, Steve Rees, Elizabeth Quinn, Catherine A. Kettleborough, Andrew Green, Zaynab Neetoo-Isseljee, Andrew J. Brown, Mark Wigglesworth
Publikováno v:
Journal of biomolecular screening. 18(5)
A variety of G-protein-coupled receptor (GPCR) screening technologies have successfully partnered a number of GPCRs with their cognate ligands. GPCR-mediated β-arrestin recruitment is now recognized as a distinct intracellular signaling pathway, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bfcec6c3010fbc746cbb949b355855
https://pubmed.ncbi.nlm.nih.gov/23396314
https://pubmed.ncbi.nlm.nih.gov/23396314
Publikováno v:
Methods in Molecular Biology ISBN: 9781617799082
The recruitment of arrestins to activated 7TMRs results in the activation of alternative signaling pathways, quenching of G-protein activation, and coupling to clathrin-mediated endocytosis. The nearly ubiquitous involvement of arrestin in 7TMR signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e3e15041e4397b82943c330b0d0f72e
https://doi.org/10.1007/978-1-61779-909-9_9
https://doi.org/10.1007/978-1-61779-909-9_9
Publikováno v:
Methods in Molecular Biology ISBN: 9781617799082
More than two-thirds of all known G-protein coupled receptors are known to modulate the function of adenylate cyclase resulting in altered levels of cAMP. In turn, cAMP fluctuations transform agonist binding events into physiological changes in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01664e4ad13fdce808be66d263e04a12
https://doi.org/10.1007/978-1-61779-909-9_8
https://doi.org/10.1007/978-1-61779-909-9_8