Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Daniel Bakowski"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels together regulate Ca2+ influx in eukaryotic cells. Here authors show that two Ca2+-dependent transcription factors, NFAT1 and c-fos, have different requirements for t
Externí odkaz:
https://doaj.org/article/f7012bdab71a4863ad46f80012f557ad
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105586 (2014)
Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate local inflammatory responses. However, the identity of epithelial
Externí odkaz:
https://doaj.org/article/5795468b961d4655b195f479740556df
Publikováno v:
Annual Review of Pharmacology and Toxicology. 61:629-654
Calcium (Ca2+) release–activated Ca2+ (CRAC) channels are a major route for Ca2+ entry in eukaryotic cells. These channels are store operated, opening when the endoplasmic reticulum (ER) is depleted of Ca2+, and are composed of the ER Ca2+ sensor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb3e12a44ef5efc063c8c21130d85e4f
https://doi.org/10.1146/annurev-pharmtox-031620-105135
https://doi.org/10.1146/annurev-pharmtox-031620-105135
Autor:
Stephen J Mills, Ana M. Rossi, Daniel Bakowski, Vera Konieczny, Colin W. Taylor, Barry V. L. Potter
Publikováno v:
Journal of Medicinal Chemistry
Analogues of the Ca2+-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P3] are important synthetic targets. Replacement of the α-glucopyranosyl motif in the natural product mimic adenophostin 2 by d-chiro-inositol i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92890ded947a792bbeaa992d5f20b5ce
http://europepmc.org/articles/PMC7104261
http://europepmc.org/articles/PMC7104261
Publikováno v:
Annual review of pharmacology and toxicology. 61
Calcium (Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6fb1ab6d6426ba84fb9d55c833d6381
https://pubmed.ncbi.nlm.nih.gov/32966177
https://pubmed.ncbi.nlm.nih.gov/32966177
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Store-operated Ca2+ entry, involving endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels, is a widespread and evolutionary conserved Ca2+ influx pathway. This form of Ca2+ influx occurs at discrete loci where periphera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a0d540a73d5784a4920bc45aa4a816
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
The Journal of Physiology
Key points Ca2+ entry through Ca2+ release‐activated Ca2+ channels activates numerous cellular responses. Under physiological conditions of weak intracellular Ca2+ buffering, mitochondrial Ca2+ uptake regulates CRAC channel activity.Knockdown of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6279fdad63a1350037c580da52b09c3
https://pubmed.ncbi.nlm.nih.gov/30582626
https://pubmed.ncbi.nlm.nih.gov/30582626
In non-excitable cells, the major Ca2+ entry pathway is the store-operated pathway in which emptying of intracellular Ca2+ stores activates Ca2+ channels in the plasma membrane. In many cell types, store-operated influx gives rise to a Ca2+-selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c47192dcfb797e6f7e9c0ed5c52f5e3
https://doi.org/10.1113/jphysiol.2001.012826
https://doi.org/10.1113/jphysiol.2001.012826
One popular model for the activation of store-operated Ca2+ influx is the secretion-like coupling mechanism, in which peripheral endoplasmic reticulum moves to the plasma membrane upon store depletion thereby enabling inositol 1,4,5-trisphosphate (In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0513e9aa74a1ce699a0706955bda5c8
https://ora.ox.ac.uk/objects/uuid:88cbc96f-2450-45cd-91be-5d3fec65f8a1
https://ora.ox.ac.uk/objects/uuid:88cbc96f-2450-45cd-91be-5d3fec65f8a1
Publikováno v:
Current Biology
Summary NFAT-dependent gene expression is essential for the development and function of the nervous, immune, and cardiovascular systems and kidney, bone, and skeletal muscle [1]. Most NFAT protein resides in the cytoplasm because of extensive phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41ceb93801c1996463032f79756cc1e
https://ora.ox.ac.uk/objects/uuid:4b45b094-7607-4676-b337-c952b8444fa7
https://ora.ox.ac.uk/objects/uuid:4b45b094-7607-4676-b337-c952b8444fa7