Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Daniel B. Stetson"'
Autor:
Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Castineira, Alison M Kell, Adriana Forero, Shivam A Zaver, Katharina Esser-Nobis, Justin A Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M Clingan, Eileen T McAnarney, Amy EL Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J Allenspach, Jennifer L Hyde, Vineet D Menachery, Saumendra N Sarkar, Joshua J Woodward, Daniel B Stetson, John Kenneth Baillie, Jane H Buckner, Michael Gale Jr, Ram Savan
Publikováno v:
eLife, Vol 10 (2021)
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields
Externí odkaz:
https://doaj.org/article/3265b04191644b45bacaf4c20c760cca
Autor:
Quinton M. Dowling, Hannah E. Volkman, Elizabeth E. Gray, Sergey Ovchinnikov, Stephanie Cambier, Asim K. Bera, Banumathi Sankaran, Max R. Johnson, Matthew J. Bick, Alex Kang, Daniel B. Stetson, Neil P. King
Publikováno v:
Nature Structural & Molecular Biology. 30:72-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::327402f7257c88d20de19eff584d1a8d
https://doi.org/10.1038/s41594-022-00862-z
https://doi.org/10.1038/s41594-022-00862-z
Publikováno v:
eLife, Vol 8 (2019)
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated. A widely accepted explanatio
Externí odkaz:
https://doaj.org/article/46f8bab3fb4747f7b5afb3e57caff9ae
Autor:
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst
Publikováno v:
Nature. 607:769-775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6acf40906993a684003e0609cfecb2
https://doi.org/10.1038/s41586-022-04896-7
https://doi.org/10.1038/s41586-022-04896-7
Autor:
Dmitri I. Kotov, Ophelia V. Lee, Charlotte Langner, Jaresley V. Guillen, Joshua M. Peters, Andres Moon, Eileen M. Burd, Kristen C. Witt, Daniel B. Stetson, David L. Jaye, Bryan D. Bryson, Russell E. Vance
SummaryMycobacterium tuberculosis(Mtb) causes 1.5 million deaths annually. Active tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the cellular mechanisms underlying tuberculosis pathogenesis remain poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a5f7dc7512329766f1f238be9138a6f
https://doi.org/10.1101/2022.10.06.511233
https://doi.org/10.1101/2022.10.06.511233
Publikováno v:
Immunity. 55(10)
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that activates the antiviral response through the adaptor protein stimulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e712b6ff73ce8d8f299bbb719d29c2bb
https://pubmed.ncbi.nlm.nih.gov/36070769
https://pubmed.ncbi.nlm.nih.gov/36070769
Autor:
Quinton M, Dowling, Hannah E, Volkman, Elizabeth E, Gray, Sergey, Ovchinnikov, Stephanie, Cambier, Asim K, Bera, Banumathi, Sankaran, Max R, Johnson, Matthew J, Bick, Alex, Kang, Daniel B, Stetson, Neil P, King
Publikováno v:
Nature structuralmolecular biology.
Cyclic GMP-AMP synthase (cGAS) is a pattern recognition receptor critical for the innate immune response to intracellular pathogens, DNA damage, tumorigenesis and senescence. Binding to double-stranded DNA (dsDNA) induces conformational changes in cG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29cf47701e3c50b5b91036a7ead465f1
https://pubmed.ncbi.nlm.nih.gov/36593311
https://pubmed.ncbi.nlm.nih.gov/36593311
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that activates the antiviral response through the adapter protein Stimulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fd68e2a5f7b59e23c7d11e70914e3a
https://doi.org/10.1101/2021.12.03.470980
https://doi.org/10.1101/2021.12.03.470980
Autor:
Daniel B. Stetson, Yanick J. Crow
Publikováno v:
Crow, Y J & Stetson, D B 2021, ' The type I interferonopathies 10 years on ', Nature Reviews Immunology . https://doi.org/10.1038/s41577-021-00633-9
Nature Reviews. Immunology
Nature Reviews. Immunology
As brutally demonstrated by the COVID-19 pandemic, an effective immune system is essential for survival. Developed over evolutionary time, viral nucleic acid detection is a central pillar in the defensive armamentarium used to combat foreign microbia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19ce619edb55a3150d906496c369dd0
https://www.pure.ed.ac.uk/ws/files/223717154/The_type_I_interferonopathies_10_years_on.docx
https://www.pure.ed.ac.uk/ws/files/223717154/The_type_I_interferonopathies_10_years_on.docx
Autor:
Michael Gale, Ram Savan, Alison M. Kell, Eileen T. McAnarney, Vineet D. Menachery, Cate Speake, Daniel B. Stetson, Saumendra N. Sarkar, Frank Soveg, Katharina Esser-Nobis, Nandan S. Gokhale, Jennifer L. Hyde, Chiraag Balu, Jane H. Buckner, Justin A Roby, Julian R. Smith, Erola Pairo-Castineira, Snehal Ozarkar, Johannes Schwerk, Karen Cerosaletti, Shivam A. Zaver, J K Baillie, Amy E. L. Stone, Tien-Ying Hsiang, Jonathan M. Clingan, Joseph Perez, Adriana Forero, Eric J. Allenspach, Joshua J. Woodward, Uma Malhotra
Publikováno v:
Soveg, F W, Schwerk, J, Gokhale, N S, Cerosaletti, K, Smith, J R, Pairo-Castineira, E, Kell, A M, Forero, A, Zaver, S A, Esser-Nobis, K, Roby, J A, Hsiang, T-Y, Ozarkar, S, Clingan, J M, McAnarney, E T, Stone, A E, Malhotra, U, Speake, C, Perez, J, Balu, C, Allenspach, E J, Hyde, J L, Menachery, V D, Sarkar, S N, Woodward, J J, Stetson, D B, Baillie, J K, Buckner, J H, Gale, M & Savan, R 2021, ' Endomembrane targeting of human OAS1 p46 augments antiviral activity ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.71047
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5956754d0a3f58caee9c5ba3381ec8cb
https://hdl.handle.net/20.500.11820/c65fe5ea-4f46-4848-978a-9787d0d5b4ce
https://hdl.handle.net/20.500.11820/c65fe5ea-4f46-4848-978a-9787d0d5b4ce