Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniel B. McKim"'
Autor:
Allison Y. Louie, Justin S. Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B. McKim, Katiria Soto-Diaz, Romana A. Nowak, Aditi Das, Andrew J. Steelman
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non-neurotropic viruses
Externí odkaz:
https://doaj.org/article/4d5c5ecf7e7c478b9757f10881ff7b72
Autor:
Katiria Soto-Diaz, Mario Vailati-Riboni, Allison Y. Louie, Daniel B. McKim, H. Rex Gaskins, Rodney W. Johnson, Andrew J. Steelman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Microglia activation and proliferation are hallmarks of many neurodegenerative disorders and may contribute to disease pathogenesis. Neurons actively regulate microglia survival and function, in part by secreting the microglia mitogen interleukin (IL
Externí odkaz:
https://doaj.org/article/185334dc51354d5985830fbbc29456a3
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Abstract Microglia are the resident innate immune cells of the central nervous system. Limited turnover throughout the lifespan leaves microglia susceptible to age-associated dysfunction. Indeed, we and others have reported microglia develop a pro-in
Externí odkaz:
https://doaj.org/article/ea8fcedba9704270a07243b2a3443e78
Autor:
Allison Y. Louie, Joseph Tingling, Evan Dray, Jamal Hussain, Daniel B. McKim, Kelly S. Swanson, Andrew J. Steelman
Publikováno v:
The Journal of Immunology. 208:2523-2539
Influenza is a common cause of pneumonia-induced hospitalization and death, but how host factors function to influence disease susceptibility or severity has not been fully elucidated. Cellular cholesterol levels may affect the pathogenesis of influe
Autor:
Jamal Hussain, Carey G. Ousley, Steven A. Krauklis, Evan L. Dray, Jenny Drnevich, Katarzyna Justyna, Mark D. Distefano, Daniel B. McKim
Statins appear to dramatically increase sepsis survival but only when treatment is initiated prior to hospitalization. This implies that statins exhibit a delayed-onset pro-survival benefit in septic patients that results in clinical futility of stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526290d0d3cace4996db790bba8151c5
https://doi.org/10.1101/2022.09.13.507840
https://doi.org/10.1101/2022.09.13.507840
Autor:
Daniel B. McKim, John F. Sheridan, Jonathan P. Godbout, Leah M. Pyter, Karl Obrietan, Savannah R. Bever, Kyle A. Sullivan
Publikováno v:
Brain Behav Immun
Circadian rhythms influence various aspects of biology, including hormonal, immunological, and behavioral processes. These 24-hour oscillations are necessary to optimize cellular functions and to synchronize these processes with the environment. Brea
Autor:
Daniel B. McKim, John F. Sheridan, Caroline M. Sawicki, Jonathan P. Godbout, Natalie R. Gallagher, Wenyuan Yin
Publikováno v:
Brain, Behavior, and Immunity. 78:131-142
Anxiety and mood disorders affect both men and women. The majority of experimental models of stress, however, are completed using only male animals. For repeated social defeat (RSD), a rodent model, this is due to the inherent difficulty in eliciting
Autor:
Yufen Wang, Kristina G. Witcher, Caroline M. Sawicki, Wenyuan Yin, Michael D. Weber, Jonathan P. Godbout, Anzela Niraula, Daniel B. McKim, Carly G. Sobol, John F. Sheridan
Publikováno v:
Biological Psychiatry. 85:667-678
Background Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes
Autor:
Lesley C. Fisher, Jonathan P. Godbout, Diana M. Norden, Rochelle J. Deibert, Daniel B. McKim, D. Michele Basso, John F. Sheridan, Timothy D. Faw
Publikováno v:
Journal of Neurotrauma. 36:937-949
Spinal cord injury (SCI) produces a toxic inflammatory microenvironment that negatively affects plasticity and recovery. Recently, we showed glial activation and peripheral myeloid cell infiltration extending beyond the epicenter through the remote l
Autor:
Daniel B. McKim, John F. Sheridan, Timothy D. Faw, Michelle L. Humeidan, Jessica K. Lerch, Jonathan P. Godbout, Caroline M. Sawicki, D. Michele Basso, January K. Kim, Kathryn M. Madalena, Michael D. Weber
Publikováno v:
The Journal of Neuroscience. 39:1139-1149
Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated social defeat (RSD) is a mouse model of psychosocial stress that act