Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Daniel B. Horne"'
Autor:
Yonghong Bai, Daniel C-H Lin, Yan Gu, Xinchao Yu, Daniel B. Horne, Xiaosu Wu, Paul H. Lee, Xin Huang, Sudipa Ghimire-Rijal, Hao Chen, Ryan White
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bec7ffc8f4669afcc422cde2b07eb8b
https://doi.org/10.7554/elife.53311.sa2
https://doi.org/10.7554/elife.53311.sa2
Autor:
Yan Gu, Daniel C-H Lin, Paul H. Lee, Ryan White, Xiaosu Wu, Daniel B. Horne, Yonghong Bai, Xinchao Yu, Hao Chen, Sudipa Ghimire-Rijal, Xin Huang
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cea2718121b864c5ca48f8ee2ded6a
http://europepmc.org/articles/PMC7082128
http://europepmc.org/articles/PMC7082128
Autor:
Daniel B. Horne, Neil F. Langille
Publikováno v:
ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e519a4055511097d8575e0d4be97a6
https://doi.org/10.1021/bk-2019-1332.ch006
https://doi.org/10.1021/bk-2019-1332.ch006
Autor:
Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Yi-Yin Ku, Michael D. Wendt, Robert Dugger, Bryan Li, Paul Richardson, Rémy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, Frédéric St-Jean, Stefan G. Koenig, Thomas H. Pillow, Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, Neil F. Langille, Daniel B. Horne, David C. Blakemore, Thomas Brandt, Craig Knight, Sarah E. Skerratt, Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Jonathan T. Reeves, James J. Crawford, Haiming Zhang, David W. Piotrowski, Emma L. McInturff, Andrew J. Peat, Shiping Xie
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32a8bd8200356c5984cf6c6b54e8a8
https://pubmed.ncbi.nlm.nih.gov/30148953
https://pubmed.ncbi.nlm.nih.gov/30148953
Autor:
Narender R. Gavva, Gregory Dussor, Christina M. Bischoff, Weiya Wang, Carolina C. Burgos-Vega, David Dong Uk Ahn, Judy Wang, Daniel B. Horne
Publikováno v:
Cephalalgia. 36:185-193
Background Migraine headache is a neurological disorder affecting millions worldwide. However, little is known about the mechanisms contributing to migraine. Recent genome-wide association studies have found single nucleotide polymorphisms in the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc36959bb88dfdaef32efd8defeeaf8
https://doi.org/10.1177/0333102415584313
https://doi.org/10.1177/0333102415584313
Autor:
Essa Hu, Samer Chmait, Thomas T. Nguyen, Amy Porter, Kristin L. Andrews, Silke Miller, Carl Davis, Jennifer R. Allen, Robert M. Rzasa, James J. S. Treanor, Alexander J. Pickrell, Adrie D. Jones, Roxanne Kunz, Daniel B. Horne, Xiaoning Zhao, Matthew R. Kaller, Holger Monenschein, Ning Chen, Heather Eastwood, Jeffrey Clarine, Michael J. Frohn, Andreas Reichelt
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6570-6585
We report the discovery of a novel series of 2-(3-alkoxy-1-azetidinyl) quinolines as potent and selective PDE10A inhibitors. Structure-activity studies improved the solubility (pH 7.4) and maintained high PDE10A activity compared to initial lead comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a111fa0c0183c52c1f5301e3654201e
https://doi.org/10.1016/j.bmc.2014.10.013
https://doi.org/10.1016/j.bmc.2014.10.013
Autor:
Vinod F. Patel, Thomas T. Nguyen, Lewis D. Pennington, Daniel B. Horne, Michael D. Bartberger, Holger Monenschein, Stephen Hitchcock, Wenge Zhong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3607-3611
The synthesis and SAR of a series of BACE-1 hydroxyethyl amine inhibitors containing substitutions on a spirocyclobutyl moiety is described. Selectivity against cathepsin D, a related aspartyl protease with potential off target toxicity, and improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9cf462951bcfa5784ecb95fc1ba18
https://doi.org/10.1016/j.bmcl.2012.04.060
https://doi.org/10.1016/j.bmcl.2012.04.060
Autor:
Yuan Cheng, Matthew R. Kaller, Steven W. Louie, Martin Citron, Lewis D. Pennington, Daniel S. La, Matthew Weiss, Stephen J. Wood, Wenge Zhong, Michael Croghan, Toni Williamson, Scott Harried, James Brown, Kui Chen, Tisha San Miguel, Ronke Imbeah-Ampiah, Holger Monenschein, Qiufen Xue, Hongbing Huang, Patricia Lopez, Claire Rattan, Thomas Dineen, Daniel B. Horne, E. Allen Sickmier, Dean Hickman, Safura Babu-Khan, Charles Kreiman, Vivian S. W. Li, Paul H. Wen, Michael D. Bartberger, Russell Graceffa, Robert C. Wahl, Thomas T. Nguyen, Bryant Yang, Ted Judd, Joel Esmay, Vinod F. Patel, Stephen Hitchcock
Publikováno v:
Journal of Medicinal Chemistry. 55:9009-9024
A series of potent hydroxyethyl amine (HEA) derived inhibitors of β-site APP cleaving enzyme (BACE1) was optimized to address suboptimal pharmacokinetics and poor CNS partitioning. This work identified a series of benzodioxolane analogues that posse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a471f56ccce495f911c58f29307ea
https://doi.org/10.1021/jm300119p
https://doi.org/10.1021/jm300119p
Autor:
Paul H. Wen, Robert C. Wahl, Michael Croghan, Ronke Imbeah-Ampiah, Paul Acton, Stephen J. Wood, Charles Kreiman, Vivian S. W. Li, Qiufen Xue, Lewis D. Pennington, Safura Babu-Khan, Daniel B. Horne, Thomas Dineen, Wenge Zhong, Scott Harried, Douglas A. Whittington, Dean Hickman, James Brown, Martin Citron, Matthew Weiss, Daniel S. La, Holger Monenschein, Bryant Yang, E. Allen Sickmier, Tisha San Miguel, Robert T. Dunn, Russell Graceffa, Patricia Lopez, Toni Williamson, Hongbing Huang, Yuan Cheng, Kui Chen, Matthew R. Kaller, Michael D. Bartberger, Steven W. Louie, Hugo M. Vargas, Stephen Hitchcock, Thomas T. Nguyen, Vinod F. Patel, Ted Judd, Joel Esmay
Publikováno v:
Journal of Medicinal Chemistry. 55:9025-9044
We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4 inhibitory activities in this scaffold affords compounds (e.g., 1) with sufficient bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8863b7dd3a68852600abaa1a5773f2a
https://doi.org/10.1021/jm300118s
https://doi.org/10.1021/jm300118s