Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Daniel B. Constam"'
Autor:
Katarina Pinjusic, Giovanna Ambrosini, Joao Lourenco, Nadine Fournier, Christian Iseli, Nicolas Guex, Olga Egorova, Sina Nassiri, Daniel B. Constam
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly imp
Externí odkaz:
https://doaj.org/article/a5db1bfb7f9b490ca34d6dec0642efd3
Autor:
Benjamin Rothé, Yayoi Ikawa, Zhidian Zhang, Takanobu A. Katoh, Eriko Kajikawa, Katsura Minegishi, Sai Xiaorei, Simon Fortier, Matteo Dal Peraro, Hiroshi Hamada, Daniel B. Constam
Publikováno v:
PLoS Biology, Vol 21, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/a4fc1b30af8f4f42b37836227003ae3d
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106855- (2023)
Summary: The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA bindi
Externí odkaz:
https://doaj.org/article/2db92b21cff24081a67fffefb22cbf89
Autor:
Katsura Minegishi, Benjamin Rothé, Kaoru R. Komatsu, Hiroki Ono, Yayoi Ikawa, Hiromi Nishimura, Takanobu A. Katoh, Eriko Kajikawa, Xiaorei Sai, Emi Miyashita, Katsuyoshi Takaoka, Kana Bando, Hiroshi Kiyonari, Tadashi Yamamoto, Hirohide Saito, Daniel B. Constam, Hiroshi Hamada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dan
Externí odkaz:
https://doaj.org/article/7ffc6f067d6c41829dd863e590035f76
Autor:
Pierpaolo Ginefra, Bruno G.H. Filippi, Prudence Donovan, Sylvain Bessonnard, Daniel B. Constam
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2176-2189 (2018)
Summary: Furin trafficking, and that of related proprotein convertases (PCs), may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking. Here, we develop targeted biosensors that in
Externí odkaz:
https://doaj.org/article/0a11b83a8aa346d683afe0d23d5524e1
Autor:
Hiroshi Kiyonari, Emi Miyashita, Daniel B. Constam, Yayoi Ikawa, Benjamin Rothé, Eriko Kajikawa, Hiromi Nishimura, Xiaorei Sai, Tadashi Yamamoto, Hiroshi Hamada, Katsuyoshi Takaoka, Kaoru R. Komatsu, Kana Bando, Hirohide Saito, Katsura Minegishi, Hiroki Ono, Takanobu A. Katoh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here
SUMMARYPerturbations in biomolecular condensates that form by phase-transitioning are linked to a growing number of degenerative diseases. For example, mutations in a multivalent interaction network of the Ankyrin (ANK) and sterile alpha motif (SAM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b675d58bc154475b12a141d60b40356f
https://doi.org/10.1101/2021.10.07.463531
https://doi.org/10.1101/2021.10.07.463531
Autor:
Denis Djekic, Jens Anders, Adrian P. Nievergelt, Samuel M. Leitao, Alexandre Persat, Charlène Brillard, Daniel B. Constam, Xavier Pierrat, Georg E. Fantner, Vytautas Navikas, Aleksandra Radenovic, Barney Drake, Katarina Pinjusic
Publikováno v:
ACS Nano
Nanocharacterization plays a vital role in understanding the complex nanoscale organization of cells and organelles. Understanding cellular function requires high-resolution information about how the cellular structures evolve over time. A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c16a146a11bbbf68d7e300426c2cfd
https://doi.org/10.1101/2021.05.13.444009
https://doi.org/10.1101/2021.05.13.444009
Autor:
Katsuyoshi Takaoka, Yayoi Ikawa, Hirohide Saito, Katsura Minegishi, Emi Miyashita, Hiroshi Hamada, Hiroki Ono, Hiroshi Kiyonari, Kana Bando, Tadashi Yamamoto, Benjamin Rothé, Kaoru R. Komatsu, Hiromi Nishimura, Daniel B. Constam
SUMMARYMolecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8b507bfa9bf7789a6f93034391ff1f
Publikováno v:
Cellular signalling. 68
Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein Bicaudal-C1 (BICC1) which was f