Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel B Harmon"'
Autor:
Jennifer L. Kaplan, Melissa A. Marshall, Chantel C. McSkimming, Daniel B. Harmon, James C. Garmey, Stephanie N. Oldham, Peter Hallowell, Coleen A. McNamara
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 779-794 (2015)
Objective: Macrophages are important producers of obesity-induced MCP-1; however, initial obesity-induced increases in MCP-1 production precede M1 macrophage accumulation in visceral adipose tissue (VAT). The initial cellular source of obesity-induce
Externí odkaz:
https://doaj.org/article/da87b27aafea4da5a93e33162a5af5d3
Autor:
Brad Screnci, Lewis J. Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Wright, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Murphy, Daniel B. Harmon, Tom Charpentier, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers
Publikováno v:
iScience. 25:105665
The tight junction protein claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue. However, achieving therapeutic MAb specificity for this 4 transmembrane protein is challenging because it is nearly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f45f33f9be0c7261fdfc5bb530829c
https://doi.org/10.1016/j.isci.2022.105665
https://doi.org/10.1016/j.isci.2022.105665
Autor:
Brad Screnci, Lewis J. Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Rimkunas, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Muprhy, Daniel B. Harmon, Tom Charpentier, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers
Publikováno v:
Cancer Research. 82:318-318
The tight junction protein Claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue, making it a valuable therapeutic target for many solid tumor cancers. Despite their potential as cancer therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9670879b2f7035b9c6bcb9c756c4f3
https://doi.org/10.1158/1538-7445.am2022-318
https://doi.org/10.1158/1538-7445.am2022-318
Autor:
James C. Garmey, Angelina Misiou, Jack M. Hensien, Chantel McSkimming, Maria Grandoch, Melissa A. Marshall, Jens W. Fischer, Victoria Osinski, Daniel B. Harmon, Coleen A. McNamara
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: The aim of this study was to unravel mechanisms whereby deficiency of the transcription factor Id3 (inhibitor of differentiation 3) leads to metabolic dysfunction in visceral obesity. We investigated the impact of loss of Id3 on hyaluronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a181f2ee43ceebc6721c7a8d579a5
https://pubmed.ncbi.nlm.nih.gov/33380173
https://pubmed.ncbi.nlm.nih.gov/33380173
Autor:
Yimei Li, John M. Maris, Swetha Raman, Jean-Philippe Julien, Bruce R. Pawel, Maria Lane, Dimiter S. Dimitrov, Kristen A. Upton, Kristopher R. Bosse, Daniel B. Harmon, Carmen T. Navia, Doncho V. Zhelev, Hong Cui, Khushbu Patel, Samantha Buongervino, Yanping Wang, Komal S. Rathi, Zhongyu Zhu, Daniel Martinez, Benjamin Martinez
Publikováno v:
Cell Reports Medicine
Summary Glypican 2 (GPC2) is a MYCN-regulated, differentially expressed cell-surface oncoprotein and target for immune-based therapies in neuroblastoma. Here, we build on GPC2’s immunotherapeutic attributes by finding that it is also a highly expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f0da2036e550e813c69ffa152235c5
https://pubmed.ncbi.nlm.nih.gov/34337560
https://pubmed.ncbi.nlm.nih.gov/34337560
Autor:
Khushbu Patel, Hong Cui, Kristen A. Upton, Kristopher R. Bosse, Carmen T. Navia, Doncho V. Zhelev, Daniel Martinez, Daniel B. Harmon, Jean-Philippe Julien, John M. Maris, Benjamin Martinez, Bruce R. Pawel, Swetha Raman, Yanping Wang, Maria Lane, Dimiter S. Dimitrov, Samantha Buongervino, Komal S. Rathi, Zhongyu Zhu
Publikováno v:
SSRN Electronic Journal.
The signaling co-receptor heparan sulfate proteoglycan GPC2 is a MYCN-activated, differentially-expressed cell surface oncoprotein and candidate immunotherapeutic target in neuroblastoma. Here we build on GPC2’s attributes as a robust target for im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11754bce0767e2005be45ae971b89e0
https://doi.org/10.2139/ssrn.3673604
https://doi.org/10.2139/ssrn.3673604
Autor:
Iain Scott, Janet R. Manning, Michael W. Stoner, Michael J. Jurczak, Robert M. O'Doherty, Kaiyuan Wu, Jian H. Li, Michael N. Sack, Bingxian Xie, Marjan Gucek, Martin P. Playford, Manling Zhang, Yong Chen, Dharendra Thapa, Daniel B. Harmon, Zhongping Lu, Nehal N. Mehta
Publikováno v:
The Journal of Biological Chemistry
Sirtuin 3 (SIRT3) deacetylates and activates several mitochondrial fatty acid oxidation enzymes in the liver. Here, we investigated whether the protein acetylase GCN5 general control of amino acid synthesis 5-like 1 (GCN5L1), previously shown to oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212854e018363023bb721827a47f2fc0
https://doi.org/10.1074/jbc.ac118.005462
https://doi.org/10.1074/jbc.ac118.005462
Autor:
Michael J. Jurczak, Max C. Petersen, Lia R. Edmunds, Ali Nasiri, Gary W. Cline, Robert M. O'Doherty, Canying Lu, Abudukadier Abulizi, Brydie R. Huckestein, Gerald I. Shulman, Daniel B. Harmon, Diana K. Costa, Joao Paulo Camporez, Benjamin S. Mantell, Gina M. Butrico, Douglas J. Hartman
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 311:E105-E116
Mitochondrial dysfunction is associated with many human diseases and results from mismatch of damage and repair over the life of the organelle. PARK2 is a ubiquitin E3 ligase that regulates mitophagy, a repair mechanism that selectively degrades dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed005ab9afdb33bc81684b8130264465
https://doi.org/10.1152/ajpendo.00042.2016
https://doi.org/10.1152/ajpendo.00042.2016
Autor:
Michael J. Jurczak, Nikolas Dedousis, Eugenia Cifuentes-Pagano, Eckels Jt, Eric E. Kelley, Mandler Wk, Jianhai Du, Patrick J. Pagano, Robert M. O'Doherty, Maja Stefanovic-Racic, Brydie R. Huckestein, Daniel B. Harmon, Gregg E. Homanics, Van't Erve Tj, Yekai Wang, Ian Sipula, Sara E. Lewis
Publikováno v:
Diabetes
Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0538c102432e7ec39761bf9aac57794
https://pubmed.ncbi.nlm.nih.gov/30936145
https://pubmed.ncbi.nlm.nih.gov/30936145
Autor:
Gabriele Schoiswohl, Laura C. Alonso, Maja Stefanovic-Racic, Robert M. O'Doherty, Erin E. Kershaw, Nikolaos Dedousis, Chao Wu, Eric E. Kelley, Daniel B. Harmon, Christopher P. O'Donnell, Ian Sipula
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 315(5)
Accumulation of myeloid cells in the liver, notably dendritic cells (DCs) and monocytes/macrophages (MCs), is a major component of the metainflammation of obesity. However, the mechanism(s) stimulating hepatic DC/MC infiltration remain ill defined. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0077eb67269d6e93175780bc9f637ca7
https://pubmed.ncbi.nlm.nih.gov/30086648
https://pubmed.ncbi.nlm.nih.gov/30086648