Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Daniel Ardeljan"'
Autor:
Daniel Ardeljan, Xuya Wang, Mehrnoosh Oghbaie, Martin S. Taylor, David Husband, Vikram Deshpande, Jared P. Steranka, Mikhail Gorbounov, Wan Rou Yang, Brandon Sie, H. Benjamin Larman, Hua Jiang, Kelly R. Molloy, Ilya Altukhov, Zhi Li, Wilson McKerrow, David Fenyö, Kathleen H. Burns, John LaCava
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and OR
Externí odkaz:
https://doaj.org/article/20049d0c7d7043acb41589f76709b424
Autor:
Daniel Ardeljan, Yujuan Wang, Stanley Park, Defen Shen, Xi Kathy Chu, Cheng-Rong Yu, Mones Abu-Asab, Jingsheng Tuo, Charles G Eberhart, Timothy W Olsen, Robert F Mullins, Gary White, Sam Wadsworth, Abraham Scaria, Chi-Chao Chan
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95900 (2014)
Age-related macular degeneration (AMD) is a common yet complex retinal degeneration that causes irreversible central blindness in the elderly. Pathology is widely believed to follow loss of retinal pigment epithelium (RPE) and photoreceptor degenerat
Externí odkaz:
https://doaj.org/article/3b015d4eec8e49e781d0231aee5bd60e
Autor:
Pei Hsun Wu, Ralph H. Hruban, Jacob S. Sarnecki, Vikram Deshpande, Jef D. Boeke, Mikhail Gorbounov, Zhi Li, Daniel Ardeljan, Lindsay M. Payer, Agata Smogorzewska, Chunhong Liu, David Fenyö, Kathleen H. Burns, Jared P. Steranka, Andrew J. Holland, Martin S. Taylor
Publikováno v:
Nature structural & molecular biology
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontra
Autor:
Brendan, Antiochos, Merlin, Paz, Jessica, Li, Daniel W, Goldman, Michelle, Petri, Erika, Darrah, Kevin, Cashman, Ignacio, Sanz, Kathleen H, Burns, Daniel, Ardeljan, Felipe, Andrade, Antony, Rosen
Publikováno v:
Clinical and Experimental Rheumatology.
Long Interspersed Element 1 (LINE-1) is an endogenous retroelement that constitutes a significant portion of the human genome and has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The LINE-1 RNA chaperone protein ORF1p wa
Autor:
Peter A. Calabresi, Jared P. Steranka, Daniel Ardeljan, JaNiece Walker, Kathleen H. Burns, Thomas A. Cooper, Lindsay M. Payer, Kathryn C. Fitzgerald
Publikováno v:
Nucleic Acids Research
RNA splicing is a highly regulated process dependent on sequences near splice sites. Insertions of Alu retrotransposons can disrupt splice sites or bind splicing regulators. We hypothesized that some common inherited polymorphic Alu insertions are re
Autor:
John LaCava, Zhi Li, Mikhail Gorbounov, H. Benjamin Larman, Wan Rou Yang, Brandon M. Sie, Wilson McKerrow, Mehrnoosh Oghbaie, Hua Jiang, Jared P. Steranka, Kelly R. Molloy, Xuya Wang, David Husband, Daniel Ardeljan, Vikram Deshpande, David Fenyö, Martin S. Taylor, Ilya Altukhov, Kathleen H. Burns
Publikováno v:
Mobile DNA
Mobile dna, 11(1):1. BMC
Mobile DNA, Vol 11, Iss 1, Pp 1-19 (2019)
Mobile dna, 11(1):1. BMC
Mobile DNA, Vol 11, Iss 1, Pp 1-19 (2019)
Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. Many
Publikováno v:
Clinical Chemistry. 63:816-822
BACKGROUND A large portion of intronic and intergenic space in our genome consists of repeated sequences. One of the most prevalent is the long interspersed element-1 (LINE-1, L1) mobile DNA. LINE-1 is rightly receiving increasing interest as a cance
Publikováno v:
Nucleic Acids Research
Transposable elements (TEs) are interspersed repeat sequences that make up much of the human genome. Their expression has been implicated in development and disease. However, TE-derived RNA-seq reads are difficult to quantify. Past approaches have ex
Transposable elements are interspersed repeat sequences that make up much of the human genome. Conventional approaches to RNA-seq analysis often exclude these sequences, fail to optimally adjudicate read alignments, or align reads to interspersed rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72102aa6e07a6998222464b188e33d1