Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Daniel Alonso-Alconada"'
Autor:
Jon Ander Alart, Antonia Álvarez, Ana Catalan, Borja Herrero de la Parte, Daniel Alonso-Alconada
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1122 (2024)
Neonatal hypoxia–ischemia is a major cause of infant death and disability. The only clinically accepted treatment is therapeutic hypothermia; however, cooling is less effective in the most severely encephalopathic infants. Here, we wanted to test t
Externí odkaz:
https://doaj.org/article/3de16942a51748afbb9c09e638d7a0fd
Autor:
Gorane Beldarrain, Marc Chillida, Enrique Hilario, Borja Herrero de la Parte, Antonia Álvarez, Daniel Alonso-Alconada
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1607 (2024)
The need for new and effective treatments for neonates suffering from hypoxia–ischemia is urgent, as the only implemented therapy in clinics is therapeutic hypothermia, only effective in 50% of cases. Cannabinoids may modulate neuronal development
Externí odkaz:
https://doaj.org/article/c5b2c996f8464a00a7c3b1747b87585b
Publikováno v:
Anales de Pediatría (English Edition), Vol 97, Iss 4, Pp 280.e1-280.e8 (2022)
Perinatal asphyxia is an event with far-reaching consequences that can lead not only to the development of neonatal encephalopathy, but also to multiple organ failure (MOF). This ailment may result from the redistribution of blood flow, which would p
Externí odkaz:
https://doaj.org/article/466487408a574daea4c9f0014c54a386
Autor:
Gorane Beldarrain, Enrique Hilario, Idoia Lara-Celador, Marc Chillida, Ana Catalan, Antonia Ángeles Álvarez-Diaz, Daniel Alonso-Alconada
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1667 (2023)
Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic hypothermia; however, cooli
Externí odkaz:
https://doaj.org/article/7018710e6fc94674879098809312205e
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/26b6339266f7412d8c98a2b0b549addb
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Cellular and tissue damage triggered after hypoxia-ischemia (HI) can be generalized and affect the neurogenic niches present in the central nervous system. As neuroregeneration may be critical for optimizing functional recovery in neonatal encephalop
Externí odkaz:
https://doaj.org/article/bfd91e26dfd3483fa00da68b81725c8f
Autor:
Andrea Duranti, Gorane Beldarrain, Antonia Álvarez, Matilde Sbriscia, Silvia Carloni, Walter Balduini, Daniel Alonso-Alconada
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 28 (2022)
The endocannabinoid (EC) system is a complex cell-signaling system that participates in a vast number of biological processes since the prenatal period, including the development of the nervous system, brain plasticity, and circuit repair. This neuro
Externí odkaz:
https://doaj.org/article/5235c59073904b6c88a775793ff03420
Autor:
Borja Herrero de la Parte, Javier Roa-Esparza, Iñigo Cearra, Inmaculada Ruiz Montesinos, Daniel Alonso-Alconada, Ana Alonso-Varona, Carmen Mar Medina, Sira Iturrizaga Correcher, Ignacio García-Alonso
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1936 (2022)
Background: Lower limb ischemia-reperfusion injury (IRI-LL) is a common major complication of orthopedic surgery, especially in elderly patients. It has previously been demonstrated that folinic acid (FA) reduced IRI-LL damage in 3–4-month-old rats
Externí odkaz:
https://doaj.org/article/ba3a808579d8481894ee14b45829b889
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1166 (2022)
The endocannabinoid system is widespread through the body and carries out a wide variety of functions. However, its involvement in other pathologies, such as cancer, still needs further attention. We aim to investigate the role of CB2 receptor during
Externí odkaz:
https://doaj.org/article/7d35d517baa0401da93dca20717f3f87
Autor:
Nicola J. Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://doaj.org/article/7daf6abf1444477d8d26b24a12891d49