Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Daniel Aberdam"'
Autor:
Lubov Turovsky, Ghazal Kheshaiboun, Gharam Yassen, Sara Nagosa, Ilanit Boyango, Aya Amitai-Lange, Swarnabh Bhattacharya, Neta Ilan, Israel Vlodavsky, Daniel Aberdam, Ruby Shalom-Feuerstein, Emily Avitan-Hersh
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-10 (2024)
Abstract miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation en
Externí odkaz:
https://doaj.org/article/81c6513c80504b699b3cd22ba2134fe7
Autor:
Jos G A Smits, Dulce Lima Cunha, Maryam Amini, Marina Bertolin, Camille Laberthonnière, Jieqiong Qu, Nicholas Owen, Lorenz Latta, Berthold Seitz, Lauriane N Roux, Tanja Stachon, Stefano Ferrari, Mariya Moosajee, Daniel Aberdam, Nora Szentmary, Simon J van Heeringen, Huiqing Zhou
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002336 (2023)
The transparent corneal epithelium in the eye is maintained through the homeostasis regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on epidermal keratinocytes for renewal. Despite their cellular similarities, the prec
Externí odkaz:
https://doaj.org/article/c523fd35c9044ca68bcfe92e2129b496
Autor:
Isabelle Petit, Ayelet Levy, Soline Estrach, Chloé C. Féral, Andrea Gonçalves Trentin, Florent Dingli, Damarys Loew, Jieqiong Qu, Huiqing Zhou, Clotilde Théry, Céline Prunier, Daniel Aberdam, Olivier Ferrigno
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Fibroblast growth factor-2 (FGF2) has multiple roles in cutaneous wound healing but its natural low stability prevents the development of its use in skin repair therapies. Here we show that FGF2 binds the outer surface of dermal fibroblast (
Externí odkaz:
https://doaj.org/article/6f3c4cf3711b41db9cbe10a027fef673
Publikováno v:
Cells, Vol 12, Iss 4, p 617 (2023)
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous cellular signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Once activated through phosphorylation, these MAPKs in turn phosphory
Externí odkaz:
https://doaj.org/article/020d2b8114e240a99de43d7630aba664
Autor:
Sara Nagosa, Friederike Leesch, Daria Putin, Swarnabh Bhattacharya, Anna Altshuler, Laura Serror, Aya Amitai-Lange, Waseem Nasser, Edith Aberdam, Matthieu Rouleau, Sudhir G. Tattikota, Matthew N. Poy, Daniel Aberdam, Ruby Shalom-Feuerstein
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1991-2004 (2017)
Summary: miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related fun
Externí odkaz:
https://doaj.org/article/820af42a71f64d11a72a250c49004c75
Autor:
Ana Freije, Rut Molinuevo, Laura Ceballos, Marta Cagigas, Pilar Alonso-Lecue, René Rodriguez, Pablo Menendez, Daniel Aberdam, Ernesto De Diego, Alberto Gandarillas
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1349-1360 (2014)
Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma (SCC). By adapting the small hairpin RNA (shRNA) technology, we
Externí odkaz:
https://doaj.org/article/e0eb7951ac3e478896bd90c1eccf866c
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179913 (2017)
Induced pluripotent stem cells hold great potential to produce unlimited amount of differentiated cells as cellular source for regenerative medicine but also for in vitro drug screening and cytotoxicity tests. Ocular toxicity testing is mandatory to
Externí odkaz:
https://doaj.org/article/ec8f3329a0e5429194e2e63d7aeed605
Autor:
Zohar Wolchinsky, Shoham Shivtiel, Evelyn Nathalie Kouwenhoven, Daria Putin, Eli Sprecher, Huiqing Zhou, Matthieu Rouleau, Daniel Aberdam
Publikováno v:
Stem Cell Research, Vol 12, Iss 1, Pp 49-59 (2014)
The transcription factor p63, member of the p53 gene family, encodes for two main isoforms, TAp63 and ΔNp63 with distinct functions on epithelial homeostasis and cancer. Recently, we discovered that TAp63 is essential for in vitro cardiogenesis and
Externí odkaz:
https://doaj.org/article/920fabe41f99492385b882918deb3812
Autor:
Alain Medawar, Thierry Virolle, Philippe Rostagno, Stéphanie de la Forest-Divonne, Karen Gambaro, Matthieu Rouleau, Daniel Aberdam
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3441 (2008)
In vivo studies have demonstrated that p63 plays complex and pivotal roles in pluristratified squamous epithelial development, but its precise function and the nature of the isoform involved remain controversial. Here, we investigate the role of p63
Externí odkaz:
https://doaj.org/article/aee00aa16261414a8750556c7088665a
Autor:
Arianne J.H. van Velthoven, Tor P. Utheim, Maria Notara, Dominique Bremond-Gignac, Francisco C. Figueiredo, Heli Skottman, Daniel Aberdam, Julie T. Daniels, Giulio Ferrari, Christina Grupcheva, Carina Koppen, Mohit Parekh, Thomas Ritter, Vito Romano, Stefano Ferrari, Claus Cursiefen, Neil Lagali, Vanessa L.S. LaPointe, Mor M. Dickman
Publikováno v:
Survey of Ophthalmology.