Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Daniel A. Kirschner"'
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 231-245 (2022)
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation, maintenance, and patholog
Externí odkaz:
https://doaj.org/article/e26932fff54d4084b010438bb6c32038
Autor:
Davide Visigalli, Giovanna Capodivento, Abdul Basit, Roberto Fernández, Zeeshan Hamid, Barbora Pencová, Chiara Gemelli, Daniela Marubbi, Cecilia Pastorino, Adrienne M. Luoma, Christian Riekel, Daniel A. Kirschner, Angelo Schenone, José A. Fernández, Andrea Armirotti, Lucilla Nobbio
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
In Charcot–Marie–Tooth type 1A (CMT1A), Schwann cells exhibit a preponderant transcriptional deficiency of genes involved in lipid biosynthesis. This perturbed lipid metabolism affects the peripheral nerve physiology and the structure of peripher
Externí odkaz:
https://doaj.org/article/dab3a83382504d50bb13125de0d5d8ed
Autor:
Laura Cantu’, Laura Colombo, Tatiana Stoilova, Bruno Demé, Hideyo Inouye, Rachel Booth, Valeria Rondelli, Giuseppe Di Fede, Fabrizio Tagliavini, Elena Del Favero, Daniel A. Kirschner, Mario Salmona
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2 of the amyloid-β (Aβ) sequence. This mutation is associated with the early onset
Externí odkaz:
https://doaj.org/article/3d016ab70be7468d919fc3a03956ec25
Autor:
Daniel A. Kirschner, Allen E. Blaurock
Publikováno v:
Myelin ISBN: 9780203746141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ff2f847372e735448ac16e1815cfd2
https://doi.org/10.1201/9780203746141-2
https://doi.org/10.1201/9780203746141-2
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation, maintenance, and patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec314a2ba51a50ff39ae10d67639cd8
https://doi.org/10.1101/2021.12.17.473245
https://doi.org/10.1101/2021.12.17.473245
Autor:
Eliezer Masliah, Abba J. Kastin, Thomas Lake, Alan D. Snow, Paula Y. Choi, Lesley Larsen, Judy Cam, Steven G. Wood, Joel Cummings, Qubai Hu, Edward Rockenstein, Weihong Pan, Stephen Lorimer, Beth P. Nguyen, Daniel A. Kirschner, Rudolph E. Tanzi, Gerardo M. Castillo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-28 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-28 (2019)
Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive decline. In the present investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d975ef56ab3bc2942bb6948abcd20e4
http://europepmc.org/articles/PMC6365538
http://europepmc.org/articles/PMC6365538
Autor:
Qin Su, Elif M. Sikoglu, Daniel A. Kirschner, Jia Li, Reuben Matalon, Thomas G Hampton, Seemin Seher Ahmed, Andrew R. Denninger, Brian K. Kaspar, Stefan A. Schattgen, Guangping Gao, Ashley E. Frakes
Publikováno v:
Molecular Therapy. 24:1030-1041
Aspartoacylase (AspA) gene mutations cause the pediatric lethal neurodegenerative Canavan disease (CD). There is emerging promise of successful gene therapy for CD using recombinant adeno-associated viruses (rAAVs). Here, we report an intracerebroven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb26654d2cbc4e18d8e122796ff72a
https://doi.org/10.1038/mt.2016.68
https://doi.org/10.1038/mt.2016.68
Autor:
Fonghsu Kuo, Michelle Crowther, Adrienne M. Luoma, Ozgur Cakici, Andrew R. Denninger, Pedro Brites, Daniel A. Kirschner, Robin L. Avila
Publikováno v:
Free Radical Biology and Medicine. 84:296-310
Reactive oxygen species (ROS) are implicated in a range of degenerative conditions, including aging, neurodegenerative diseases, and neurological disorders. Myelin is a lipid-rich multilamellar sheath that facilitates rapid nerve conduction in verteb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3c4227d0f169a072911c3a03113d20
https://doi.org/10.1016/j.freeradbiomed.2015.03.012
https://doi.org/10.1016/j.freeradbiomed.2015.03.012
Autor:
Manfred Burghammer, Andrew R. Denninger, Fonghsu Kuo, Daniel A. Kirschner, Hideyo Inouye, Britta Weinhausen
Publikováno v:
Journal of structural biology. 200(3)
Previous raster-scanning with a 1μm X-ray beam of individual, myelinated fibers from glutaraldehyde-fixed rat sciatic nerve revealed a spatially-dependent variation in the diffraction patterns from single fibers. Analysis indicated differences in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa3d216c84c71b03181ad94176c8b40
https://pubmed.ncbi.nlm.nih.gov/28698109
https://pubmed.ncbi.nlm.nih.gov/28698109
Autor:
Jeanette T. Moore, Saurav Bhowmick, Kelly L. Drew, Brian T. Rasley, Daniel L. Kirschner, Mary C. Curry, Emily G. Westbrook
Publikováno v:
ACS chemical neuroscience. 8(6)
Ischemic reperfusion (I/R) injury is associated with a complex and multifactorial cascade of events involving excitotoxicity, acidotoxicity, and ionic imbalance. While it is known that acidosis occurs concomitantly with glutamate-mediated excitotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c46de28770a9afd193edcd2fa9d035c
https://pubmed.ncbi.nlm.nih.gov/28117962
https://pubmed.ncbi.nlm.nih.gov/28117962