Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Daniel A. Goodman"'
Autor:
Yingleong Chan, Ying Kai Chan, Daniel B. Goodman, Xiaoge Guo, Alejandro Chavez, Elaine T. Lim, George M. Church
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor i
Externí odkaz:
https://doaj.org/article/91ce078fac0a446897ce139106322d9d
Autor:
Daniel B. Goodman, Gleb Kuznetsov, Marc J. Lajoie, Brian W. Ahern, Michael G. Napolitano, Kevin Y. Chen, Changping Chen, George M. Church
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial genome engineering. We describe Millstone, a web-based platform that automat
Externí odkaz:
https://doaj.org/article/8459d7a4fb44406887544a589bea7343
Autor:
Gleb Kuznetsov, Daniel B. Goodman, Gabriel T. Filsinger, Matthieu Landon, Nadin Rohland, John Aach, Marc J. Lajoie, George M. Church
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We apply our method to identify six single nucleotide mutations that recover 59% of the
Externí odkaz:
https://doaj.org/article/6d97b73a33114393895f5b605eecfd99
Autor:
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Zhongmei Li, Cody T. Mowery, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Eric Shifrut, Theodore L. Roth, Alexander Marson
Publikováno v:
Blood. 140:7404-7406
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3199ef76e0a4f0a95b1b9899764c73b
https://doi.org/10.1182/blood-2022-158641
https://doi.org/10.1182/blood-2022-158641
Autor:
Luhan Yang, Adrian W. Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Bryan Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang, George Church
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Precision genome engineering using homology donors and the endogenous DNA break repair machinery and recently CRISPR-Cas9 targeted APOBECs have been demonstrated. Here the authors design zinc-finger and TALE chimeric deaminases and investigate editin
Externí odkaz:
https://doaj.org/article/46f1a4a987da4603908d6583916fecd1
Autor:
Daniel B. Goodman, Camillia S. Azimi, Kendall Kearns, Alexis Talbot, Kiavash Garakani, Julie Garcia, Nisarg Patel, Byungjin Hwang, David Lee, Emily Park, Vivasvan S. Vykunta, Brian R. Shy, Chun Jimmie Ye, Justin Eyquem, Alexander Marson, Jeffrey A. Bluestone, Kole T. Roybal
Publikováno v:
Science translational medicine, vol 14, iss 670
Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers but have shown limited efficacy in persistent, recurrent malignancies. Here, we introduce “CAR Pooling,” a multiplexed approach to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86774c205dff95513b6cbc907d3d1bc
https://doi.org/10.1126/scitranslmed.abm1463
https://doi.org/10.1126/scitranslmed.abm1463
Autor:
Michael V. Nguyen, Daniel A. Goodman
Publikováno v:
Physical Medicine and Rehabilitation Pocketpedia ISBN: 9780826156273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ab6d1ad645196ae8d70fce8b0829be
https://doi.org/10.1891/9780826156280.0001
https://doi.org/10.1891/9780826156280.0001
Autor:
Daniel Ross Goodman
Publikováno v:
Harvard Theological Review. 114:536-560
The place of interfaith dialogue in Orthodox Judaism has been the subject of extensive discussion. This article offers a reading of Rabbi Joseph Soloveitchik's and Rabbi Irving Greenberg's stances on interfaith dialogue that situates them in a Jewish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384460471d1b751e8999984a911b7047
https://doi.org/10.1017/s0017816021000286
https://doi.org/10.1017/s0017816021000286
Autor:
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Zhongmei Li, Cody T. Mowery, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Eric Shifrut, Theodore L. Roth, Alexander Marson
SUMMARYChronic stimulation can cause T cell dysfunction and limit efficacy of cellular immunotherapies. CRISPR screens have nominated gene targets for engineered T cells, but improved methods are required to compare large numbers of synthetic knockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168f46d465c9cfad52b2b8e8995fc5ac
https://doi.org/10.1101/2022.07.27.501186
https://doi.org/10.1101/2022.07.27.501186
Autor:
Daniel Ross Goodman
Publikováno v:
Ethical Economy ISBN: 9783031102035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f7ca2ff37c2307bed665272413bb53
https://doi.org/10.1007/978-3-031-10204-2_7
https://doi.org/10.1007/978-3-031-10204-2_7