Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Daniel A. Goodenough"'
Publikováno v:
Molecular Biology of the Cell
The mechanisms regulating assembly of gap junctions are not well defined. It is shown that assembly of gap junctions containing Cx50 requires both a PDZ domain–binding motif at the connexin C-terminus and the scaffolding protein ZO-1.
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Publikováno v:
Glia. 59:1064-1074
CNS glia exhibit a variety of gap junctional interactions: between neighboring astrocytes, between neighboring oligodendrocytes, between astrocytes and oligodendrocytes, and as 'reflexive' structures between layers of myelin in oligodendrocytes. Toge
Publikováno v:
Glia. 59:26-34
Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the i
Autor:
Jianghui Hou, Daniel A. Goodenough
Publikováno v:
Current Opinion in Nephrology and Hypertension. 19:483-488
Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport fu
Autor:
Jianghui Hou, Daniel A. Goodenough, Mingli Hou, Aparna Renigunta, Antonio S. Gomes, David L. Paul, Siegfried Waldegger
Publikováno v:
Proceedings of the National Academy of Sciences. 106:15350-15355
Claudins are tight junction integral membrane proteins that are key regulators of the paracellular pathway. Defects in claudin-16 (CLDN16) and CLDN19 function result in the inherited human renal disorder familial hypomagnesemia with hypercalciuria an
Publikováno v:
Annals of the New York Academy of Sciences. 1165:148-151
Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability
Autor:
Stefanie Weber, Eberhard Kuwertz-Bröking, Tomáš Seeman, Hammad O. Alshaya, Velibor Tasic, André Schaller, Rodo O. von Vigier, Daniel A. Goodenough, Jörg Dötsch, Sabina Gallati, Katalin Dittrich, Jianghui Hou, Amira Peco-Antic, Martin Konrad, Jameela A. Kari
Publikováno v:
Journal of the American Society of Nephrology. 19:171-181
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive tubular disorder caused by CLDN16 mutations. CLDN16 encodes the renal tight junction protein claudin-16, which is important for the paracellular re
Publikováno v:
Journal of Biological Chemistry. 281:36117-36123
Claudins are tight junction proteins that play a key selectivity role in the paracellular conductance of ions. Numerous studies of claudin function have been carried out using the overexpression strategy to add new claudin channels to an existing par
Autor:
Steven S. Scherer, David L. Paul, Marta Majdan, Daniela M. Menichella, Rajeshwar Awatramani, Daniel A. Goodenough, Erich E. Sirkowski
Publikováno v:
The Journal of Neuroscience. 26:10984-10991
Mice lacking the K+channel Kir4.1 or both connexin32 (Cx32) and Cx47 exhibit myelin-associated vacuoles, raising the possibility that oligodendrocytes, and the connexins they express, contribute to recycling the K+evolved during neuronal activity. To
Publikováno v:
Molecular Biology of the Cell. 17:1871-1879
Transforming growth factor beta 1 (TGF-β1) has been shown to induce epithelial-mesenchymal transition (EMT) during various stages of embryogenesis and progressive disease. This alteration in cellular morphology is typically characterized by changes