Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

Autor: Rutulkumar Patel, Daniel E. Cooper, Kushal T. Kadakia, Annamarie Allen, Likun Duan, Lixia Luo, Nerissa T. Williams, Xiaojing Liu, Jason W. Locasale, David G. Kirsch

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract Diverse tumor metabolic phenotypes are influenced by the environment and genetic lesions. Whether these phenotypes extend to rhabdomyosarcoma (RMS) and how they might be leveraged to design new therapeutic approaches remains an open question

Externí odkaz: https://doaj.org/article/0569329ceb654b2aad711245a321df14

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy

Autor: Ashley Priddey, Michael Xin Hua Chen-Xu, Daniel James Cooper, Serena MacMillan, Georg Meisl, Catherine K. Xu, Myra Hosmillo, Ian G. Goodfellow, Rafael Kollyfas, Rainer Doffinger, John R. Bradley, Irina I. Mohorianu, Rachel Jones, Tuomas P. J. Knowles, Rona Smith, Vasilis Kosmoliaptsis

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

BackgroundPatients with autoimmune/inflammatory conditions on anti-CD20 therapies, such as rituximab, have suboptimal humoral responses to vaccination and are vulnerable to poorer clinical outcomes following SARS-CoV-2 infection. We aimed to examine

Externí odkaz: https://doaj.org/article/9abd8088be4647aa809eb3c937e8e385

Evaluating potential changes to the US Chukchi Sea bottom trawl survey design via simulation testing

Autor: Zack S. Oyafuso, Lewis A. K. Barnett, Margaret C. Siple, Daniel W. Cooper, Stan Kotwicki

Publikováno v: Frontiers in Marine Science, Vol 10 (2023)

The US Chukchi Sea consists of the waters off the northwest of Alaska and is a naturally dynamic ice-driven ecosystem. The impacts from climate change are affecting the Arctic marine ecosystem as well as the coastal communities that rely on healthy m

Externí odkaz: https://doaj.org/article/3d6c47aba9464c95807c2b36102bea5b

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

Autor: Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through diff

Externí odkaz: https://doaj.org/article/766e52fb320d462daa94e2918960d612

Editorial: Global urban biodiversity and the importance of scale

Autor: Daniel T. Blumstein, Marina Alberti, Joscha Beninde, Rachel V. Blakey, Joseph R. Burger, Daniel S. Cooper, Chase A. Niesner, Christopher J. Schell, Masashi Soga, Kenta Uchida

Publikováno v: Frontiers in Conservation Science, Vol 4 (2023)

Externí odkaz: https://doaj.org/article/b71e2c8cfaf8403081faf7fd6ecf5201