Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Daniel A. Brody"'
Autor:
Dale L. Boger, Shouliang Yang, R. Matthew Cross, Daniel W. Carney, Aleksandar Radakovic, Daniel M. Brody, Vyom Shukla, John C. Lukesh, Katharine K. Duncan, Manuela M. Brütsch, Huijun Dong
Publikováno v:
Journal of Medicinal Chemistry. 60:7591-7604
A series of 180 vinblastine 20' amides were prepared in three steps from commercially available starting materials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful functionalization strategy. Clear structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f59c28cf90ee2feb2751e99d442147
https://doi.org/10.1021/acs.jmedchem.7b00958
https://doi.org/10.1021/acs.jmedchem.7b00958
Autor:
Manuela M. Brütsch, Dale L. Boger, Daniel M. Brody, Colin K. Skepper, Timothy J. Barker, John C. Lukesh, Shouliang Yang, Kuppusamy Sankar
Publikováno v:
Chemical Science. 8:1560-1569
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f5520d2ace94d01296e9782792efaaf
https://doi.org/10.1039/c6sc04146a
https://doi.org/10.1039/c6sc04146a
Publikováno v:
Journal of the American Chemical Society
Many natural products, including vinblastine, have not been easily subjected to simplifications in their structures by synthetic means or modifications by late-stage semi-synthetic derivatization in ways that enhance their biological potency. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bfda78b7bb8e10bd14455110d63dc3
https://doi.org/10.1021/jacs.6b04330
https://doi.org/10.1021/jacs.6b04330
Autor:
Alain Biron, Andrea Bishop, Patricia Alfaro, Gabrielle Cunningham-Allard, Alexander Sasha Dubrovsky, Daniel Adam Brody, Mher Barbarian
Publikováno v:
Journal of patient safety. 17(8)
INTRODUCTION Although the Child Hospital Consumer Assessment of Healthcare Providers and Systems is a validated tool for the inpatient experience, it may not address features unique to the pediatric emergency department (PED). There is currently no p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d473ef248460063859bd27b3d4dc199
https://pubmed.ncbi.nlm.nih.gov/29432338
https://pubmed.ncbi.nlm.nih.gov/29432338
Autor:
Dale L. Boger, Anne F. Kornahrens, Armand B. Cognetta, Daniel M. Brody, Benjamin F. Cravatt, Megan L. Matthews
Publikováno v:
Journal of the American Chemical Society. 139(20)
The design and examination of 4,1,2-benzoxathiazin-3-one 1,1-dioxides as candidate serine hydrolase inhibitors are disclosed, and represent the synthesis and study of a previously unexplored heterocycle. This new class of activated cyclic carbamates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badc6e3ede63ed393354154d650596cd
https://pubmed.ncbi.nlm.nih.gov/28498651
https://pubmed.ncbi.nlm.nih.gov/28498651
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(35)
Approaches to improving the biological properties of natural products typically strive to modify their structures to identify the essential pharmacophore, or make functional group changes to improve biological target affinity or functional activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dbb61ef9a809730f36e311eee066f6
https://pubmed.ncbi.nlm.nih.gov/27512044
https://pubmed.ncbi.nlm.nih.gov/27512044
Publikováno v:
Bioorganicmedicinal chemistry. 24(20)
The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab8b7046a1bf14edaf16e6d4d790948
https://pubmed.ncbi.nlm.nih.gov/27221071
https://pubmed.ncbi.nlm.nih.gov/27221071
Autor:
John R. Falck, Vijaya L. Manthati, Alan T. Tang, Daniel M. Brody, Carol L. Williams, William B. Campbell, Kasem Nithipatikom
Publikováno v:
Cancer Science. 101:2629-2636
Cytochrome P450 (CYP) epoxygenases, CYP2C8, 2C9 and 2J2 mRNA and proteins, were expressed in prostate carcinoma (PC-3, DU-145 and LNCaP) cells. 11,12-Epoxyeicosatrienoic acid (11,12-EET) was the major arachidonic acid metabolite in these cells. Block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad6ca5280a53c440e0ef82170c99ed6
https://doi.org/10.1111/j.1349-7006.2010.01713.x
https://doi.org/10.1111/j.1349-7006.2010.01713.x
Publikováno v:
Tetrahedron letters. 56(23)
The preparation, characterization, and examination of the CBI-based 5-membered lactone 5 capable of serving as a prodrug or protein (antibody) conjugation reagent are disclosed along with its incorporation into the corresponding CC-1065 and duocarmyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed65cd385ece0dfcac3f29c2e67b057
https://pubmed.ncbi.nlm.nih.gov/26069351
https://pubmed.ncbi.nlm.nih.gov/26069351
