Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel A Pensinger"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009959 (2021)
Clostridioides difficile is an opportunistic diarrheal pathogen responsible for significant morbidity and mortality worldwide. A disrupted (dysbiotic) gut microbiome, commonly engendered by antibiotic treatment, is the primary risk factor for C. diff
Externí odkaz:
https://doaj.org/article/1cf022feab35495086e4f0958979b1ec
Autor:
Daniel A Pensinger, Kyle M Boldon, Grischa Y Chen, William J B Vincent, Kyle Sherman, Meng Xiong, Adam J Schaenzer, Emily R Forster, Jörn Coers, Rob Striker, John-Demian Sauer
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006001 (2016)
Obstacles to bacterial survival and replication in the cytosol of host cells, and the mechanisms used by bacterial pathogens to adapt to this niche are not well understood. Listeria monocytogenes is a well-studied Gram-positive foodborne pathogen tha
Externí odkaz:
https://doaj.org/article/48519dc5c4b54cbcb6a2eb08370eb5ae
Autor:
Daniel A. Pensinger, Horia A. Dobrila, David M. Stevenson, Nicole D. Hryckowian, Daniel Amador-Noguez, Andrew J. Hryckowian
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT The gut microbiome engenders colonization resistance against the diarrheal pathogen Clostridioides difficile, but the molecular basis of this colonization resistance is incompletely understood. A prominent class of gut microbiome-produced me
Externí odkaz:
https://doaj.org/article/41fe5440e23740f4a1f938cdd0bc569d
Autor:
TuAnh Ngoc Huynh, David S. Stevenson, William J.B. Vincent, Kyu Y. Rhee, Krizia M. Perez-Medina, Kimberly V. Gutierrez, Daniel Amador-Noguez, John-Demian Sauer, Joseph P. Dillard, Hans B. Smith, Katherine A. Black, Daniel A. Pensinger
Publikováno v:
mBio. 14
The cytosol of eukaryotic host cells is an intrinsically hostile environment for bacteria. Understanding how cytosolic pathogens adapt to and survive in the cytosol is critical to developing novel therapeutic interventions for these pathogens. The cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371783a28a0f6b3537c46e05e7ff9a7a
https://doi.org/10.1128/mbio.00073-23
https://doi.org/10.1128/mbio.00073-23
Autor:
Daniel A. Pensinger, Andrea T. Fisher, Horia A. Dobrila, William Van Treuren, Jackson O. Gardner, Steven K. Higginbottom, Matthew M. Carter, Benjamin Schumann, Carolyn R. Bertozzi, Victoria Anikst, Cody Martin, Elizabeth V. Robilotti, Jo May Chow, Rachael H. Buck, Lucy S. Tompkins, Justin L. Sonnenburg, Andrew J. Hryckowian
Publikováno v:
Infection and Immunity. 91
A disrupted “dysbiotic” gut microbiome engenders susceptibility to the diarrheal pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in particular the microbiota accessible carbohydrates (MACs) found in dietary f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015982d9e1c831b25f4989643d7cb525
https://doi.org/10.1128/iai.00570-22
https://doi.org/10.1128/iai.00570-22
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009959 (2021)
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
Clostridioides difficile is an opportunistic diarrheal pathogen responsible for significant morbidity and mortality worldwide. A disrupted (dysbiotic) gut microbiome, commonly engendered by antibiotic treatment, is the primary risk factor for C. diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7371353f00efca9c63e6b687b9b50dfb
https://doaj.org/article/1cf022feab35495086e4f0958979b1ec
https://doaj.org/article/1cf022feab35495086e4f0958979b1ec
Autor:
Nicole M Palacio, Jasmine Ramirez, Nawar Naseer, Daniel A. Pensinger, Mark A. Boyer, Brian M Yan, Valeria M. Reyes Ruiz, Ingharan J. Siddarthan, John-Demian Sauer, Sunny Shin
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13242-13247
Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens by activating caspase-1-dependent cytokine secretion and cell death. In mice, specific nucleotide-binding domain, leucine-rich repeat-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3758e3277745af609df9d946bbecc1
https://doi.org/10.1073/pnas.1710433114
https://doi.org/10.1073/pnas.1710433114
Publikováno v:
Trends in microbiology. 26(1)
All domains of life utilize protein phosphorylation as a mechanism of signal transduction. In bacteria, protein phosphorylation was classically thought to be mediated exclusively by histidine kinases as part of two-component signaling systems. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd70013ef000f557d441c8e960344e8
https://pubmed.ncbi.nlm.nih.gov/28734616
https://pubmed.ncbi.nlm.nih.gov/28734616
Publikováno v:
Cellular microbiology. 19(10)
Listeria monocytogenes, the causative agent of listeriosis, is an intracellular pathogen that is exquisitely evolved to survive and replicate in the cytosol of eukaryotic cells. Eukaryotic cells typically restrict bacteria from colonizing the cytosol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d169cbc39ad94bd2d21005bf470c8c69
https://pubmed.ncbi.nlm.nih.gov/28656691
https://pubmed.ncbi.nlm.nih.gov/28656691
Autor:
Joshua J. Woodward, Anthony T. Iavarone, Martin Sadilek, Daniel A. Pensinger, Young Ah Goo, TuAnh Ngoc Huynh, Mimi R. Precit, Kamakshi Sureka, Liang Tong, Ashley R. Jurado, John-Demian Sauer, Philip H. Choi, Matthieu Delince
Publikováno v:
Cell. 158:1389-1401
SummaryCyclic di-adenosine monophosphate (c-di-AMP) is a broadly conserved second messenger required for bacterial growth and infection. However, the molecular mechanisms of c-di-AMP signaling are still poorly understood. Using a chemical proteomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f42c97e2b3323ad911a944a5b0ba86a
https://doi.org/10.1016/j.cell.2014.07.046
https://doi.org/10.1016/j.cell.2014.07.046