Zobrazeno 1 - 10 of 120 pro vyhledávání: '"Daniel A Nussbaum"'
1
Akademický článek
Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers
Autor: Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz: https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
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2
Akademický článek
Hospital‐level compliance with the commission on cancer’s quality of care measures and the association with patient survival
Autor: Daniel P. Nussbaum, Christel N. Rushing, Zhifei Sun, Babatunde A. Yerokun, Mathias Worni, Robert S. Saunders, Mark B. McClellan, Donna Niedzwiecki, Rachel A. Greenup, Dan G. Blazer III
Publikováno v: Cancer Medicine, Vol 10, Iss 11, Pp 3533-3544 (2021)
Abstract Background Quality measurement has become a priority for national healthcare reform, and valid measures are necessary to discriminate hospital performance and support value‐based healthcare delivery. The Commission on Cancer (CoC) is the l
Externí odkaz: https://doaj.org/article/2201ac136bd247ecb1f3a6546ced2389
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3
Akademický článek
Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities
Autor: Alexander L. Lazarides, Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer, Brian E. Brigman, William C. Eward
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-6 (2018)
Abstract Background In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival in soft tissue sarco
Externí odkaz: https://doaj.org/article/d38428b84d3e4220b45be1ccf98f4688
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5
Akademický článek
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution
Autor: Grace R. Anderson, Peter S. Winter, Kevin H. Lin, Daniel P. Nussbaum, Merve Cakir, Elizabeth M. Stein, Ryan S. Soderquist, Lorin Crawford, Jim C. Leeds, Rachel Newcomb, Priya Stepp, Catherine Yip, Suzanne E. Wardell, Jennifer P. Tingley, Moiez Ali, Mengmeng Xu, Meagan Ryan, Shannon J. McCall, Autumn J. McRee, Christopher M. Counter, Channing J. Der, Kris C. Wood
Publikováno v: Cell Reports, Vol 20, Iss 4, Pp 999-1015 (2017)
Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we system
Externí odkaz: https://doaj.org/article/a9b233c46180479b811cfec67978789b
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