Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Daniel A Mordes"'
Autor:
Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010956 (2022)
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkins
Externí odkaz:
https://doaj.org/article/1cc5104ca63749ee94a0198a2fd4598b
Autor:
Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Jisoo Lee, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008222 (2020)
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we soug
Externí odkaz:
https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
Autor:
Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C. Thwin, Koli Basu, Matthew D. Callahan, Daniel R. Southworth, Daniel A. Mordes, Charles S. Craik, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho
Externí odkaz:
https://doaj.org/article/65e099c2e88a4ef08f3a505a925ec40b
Autor:
Arjun eKhanna, Andrew S Venteicher, Brian Patrick Walcott, Kristopher T Kahle, Daniel A Mordes, Christopher M William, Zoher eGhogawala, Christopher S Ogilvy
Publikováno v:
Frontiers in Neurology, Vol 4 (2013)
Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage who re-presented three years later with a large intraparenchyma
Externí odkaz:
https://doaj.org/article/a4413d143bc34fd6870fdcd72626b832
Publikováno v:
Frontiers in aging neuroscience. 14
Neurodegenerative disorders have been extremely challenging to treat with traditional drug-based approaches and curative therapies are lacking. Given continued progress in stem cell technologies, cell replacement strategies have emerged as concrete a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a986a29290b3d7da894dce99c5dee8c8
https://pubmed.ncbi.nlm.nih.gov/36408113
https://pubmed.ncbi.nlm.nih.gov/36408113
Autor:
Julie, Smeyers, Daniel A, Mordes
Publikováno v:
Brain. 146:4-5
This scientific commentary refers to ‘Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis’ by Ito et al. (https://doi.org/10.1093/brain/awac306).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac971ed6b9827671ad9a68ae0c547bf
https://doi.org/10.1093/brain/awac408
https://doi.org/10.1093/brain/awac408
Autor:
Sara A. M. Holec, Jisoo Lee, Abby Oehler, Felicia K. Ooi, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner, Amanda L. Woerman
Publikováno v:
Acta neuropathologica. 144(4)
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the α-synuclein gene, SNCA, have been identified as the cause o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d95041af42790fa69600526623f967c
https://pubmed.ncbi.nlm.nih.gov/36018376
https://pubmed.ncbi.nlm.nih.gov/36018376
Autor:
Steven A. McCarroll, Brian J. Joseph, Inma Cobos, Laura Bortolin, Irena Kadiu, Sulagna Ghosh, Alexander Couto, Aaron Burberry, Daniel Meyer, Kevin Eggan, Olli Pietilainen, Melissa Goldman, Francesco Limone, Beth Stevens, Martine Therrien, Daniel A. Mordes
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterised by a progressive loss of motor function. The eponymous spinal sclerosis observed at autopsy is the result of the degeneration of extratelencephalic neurons, Betz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831769520c89a3efdd9b877e0f309d6
https://doi.org/10.1101/2021.07.12.452054
https://doi.org/10.1101/2021.07.12.452054
Autor:
Smita S. Patel, Jisoo Lee, Amanda L. Woerman, Sabeen A. Kazmi, Steven H. Olson, Daniel A. Mordes, Abby Oehler, Stanley B. Prusiner
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008222 (2020)
PLoS Pathogens
PLoS pathogens, vol 16, iss 2
PLoS Pathogens
PLoS pathogens, vol 16, iss 2
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e47934d1d1405005304ce119c630a4
https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
Autor:
Sulagna Ghosh, Jin Yuan Wang, Jackson Sandoe, Joanie Mok, Maura Charlton, Steven A. Carr, Namrata D. Udeshi, Aaron Burberry, Yingying Zhang, Quan Zhen Li, Kevin Eggan, Daniel A. Mordes, Tanya Svinkina
Publikováno v:
Genes & Development. 32:929-943
While a mutation in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning the function of the protein normally encoded at this locus. To elaborate further on functions for C9ORF72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d60cec24cbd25ce2b767672a0e42e5f
https://doi.org/10.1101/gad.313932.118
https://doi.org/10.1101/gad.313932.118