Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Daniel A Lafontaine"'
Autor:
Jonathan P. Grondin, Mélanie Geffroy, Maxime Simoneau-Roy, Adrien Chauvier, Pierre Turcotte, Patrick St-Pierre, Audrey Dubé, Julie Moreau, Eric Massé, J. Carlos Penedo, Daniel A. Lafontaine
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Riboswitches regulate gene expression by modulating their structure upon metabolite binding. These RNA orchestrate several layers of regulation to achieve genetic control. Although Escherichia coli riboswitches modulate translation initiatio
Externí odkaz:
https://doaj.org/article/e2e3b13a3af948d9ada1157f5a0e958a
Publikováno v:
Frontiers in Chemistry, Vol 4 (2016)
In addition to the helical nature of double-stranded DNA and RNA, single-stranded oligonucleotides can arrange themselves into tridimensional structures containing loops, bulges, internal hairpins and many other motifs. This ability has been used for
Externí odkaz:
https://doaj.org/article/4a6c043f13f34da9aa4c78b0fd22e6b7
Autor:
Jean-François Lemay, Guillaume Desnoyers, Simon Blouin, Benoit Heppell, Laurène Bastet, Patrick St-Pierre, Eric Massé, Daniel A Lafontaine
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001278 (2011)
Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches. Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controllin
Externí odkaz:
https://doaj.org/article/7ca582ac8a9741feb9123cff5bb6053b
Autor:
Jérôme Mulhbacher, Eric Brouillette, Marianne Allard, Louis-Charles Fortier, François Malouin, Daniel A Lafontaine
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000865 (2010)
Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain. Guanine ribos
Externí odkaz:
https://doaj.org/article/8100fc22e1d54172a07dd2e9537934c0
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 916-927 (2022)
Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms.
Externí odkaz:
https://doaj.org/article/5363415cc3e6442ca8e1e5ed6510e109
Autor:
Adrien Chauvier, Frédéric Picard-Jean, Jean-Christophe Berger-Dancause, Laurène Bastet, Mohammad Reza Naghdi, Audrey Dubé, Pierre Turcotte, Jonathan Perreault, Daniel A. Lafontaine
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Riboswitches are non-coding RNA elements that detect metabolites and control expression by regulating mRNA levels or translation. Here, the authors provide evidence that theE. coli thiC riboswitch has a pause site in the translation initiation region
Externí odkaz:
https://doaj.org/article/57c5865f15864c03ba74e3b730ffa5e6
Autor:
Meredith J. Zeller, Oleg Favorov, Kelin Li, Ashok Nuthanakanti, Dina Hussein, Auréliane Michaud, Daniel A. Lafontaine, Steven Busan, Alexander Serganov, Jeffrey Aubé, Kevin M. Weeks
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The transcriptome represents an attractive but underused set of targets for small-molecule ligands. Here, we devise a technology that leverages fragment-based screening and SHAPE-MaP RNA structure probing to discover small-molecule fragments that bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b57bb3170bba51633d5d0ee1402f77f
https://doi.org/10.1073/pnas.2122660119
https://doi.org/10.1073/pnas.2122660119
Autor:
Erich, Smith-Peter, David Lalonde, Séguin, Émilie, St-Pierre, Ognjen, Sekulovic, Simon, Jeanneau, Cédrick, Tremblay-Tétreault, Anne-Marie, Lamontagne, Pierre-Étienne, Jacques, Daniel A, Lafontaine, Louis-Charles, Fortier
Publikováno v:
RNA Biol
Clostridioides difficile is the main cause of nosocomial antibiotic-associated diarrhoea. There is a need for new antimicrobials to tackle this pathogen. Guanine riboswitches have been proposed as promising new antimicrobial targets, but experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad47342a76e88cda8429d2b94c1a92d4
https://pubmed.ncbi.nlm.nih.gov/34612173
https://pubmed.ncbi.nlm.nih.gov/34612173
Autor:
Anne-Marie Lamontagne, Adrien Chauvier, Jonathan P. Grondin, Jean-François Nadon, Daniel A. Lafontaine
Publikováno v:
RNA Biology. 16:1066-1073
Transcriptional pauses have been reported in bacterial riboswitches and, in some cases, their specific positioning has been shown to be important for gene regulation. Here, we show that a hairpin structure in the Escherichia coli thiamin pyrophosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba03392542bfbfaedf7e737460e84dc1
https://doi.org/10.1080/15476286.2019.1616354
https://doi.org/10.1080/15476286.2019.1616354
Autor:
Adrien Chauvier, Julien Boudreault, Patrick St-Pierre, Pascale B. Beauregard, Adrien Rizzi, Kaley McCluskey, J. Carlos Penedo, Cibran Perez-Gonzalez, Daniel A. Lafontaine
Publikováno v:
Nucleic Acids Research
Riboswitches are cis-acting regulatory RNA biosensors that rival the efficiency of those found in proteins. At the heart of their regulatory function is the formation of a highly specific aptamer–ligand complex. Understanding how these RNAs recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fd94b316184f0bf91cc47831c88b6d
https://doi.org/10.1093/nar/gkz316
https://doi.org/10.1093/nar/gkz316