Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Daniel A Haber"'
Autor:
Rebecca D Sandlin, Keith H K Wong, Shannon N Tessier, Anisa Swei, Lauren D Bookstaver, Bennett E Ahearn, Shyamala Maheswaran, Daniel A Haber, Shannon L Stott, Mehmet Toner
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192734 (2018)
Emerging technologies have enabled the isolation and characterization of rare circulating tumor cells (CTCs) from the blood of metastatic cancer patients. CTCs represent a non-invasive opportunity to gain information regarding the primary tumor and r
Externí odkaz:
https://doaj.org/article/e3bbc559b71a4af8a537a9235ab3fba2
Autor:
S Michael Rothenberg, Kyle Concannon, Sarah Cullen, Gaylor Boulay, Alexa B Turke, Anthony C Faber, Elizabeth L Lockerman, Miguel N Rivera, Jeffrey A Engelman, Shyamala Maheswaran, Daniel A Haber
Publikováno v:
eLife, Vol 4 (2015)
Treatment of EGFR-mutant lung cancer with erlotinib results in dramatic tumor regression but it is invariably followed by drug resistance. In characterizing early transcriptional changes following drug treatment of mutant EGFR-addicted cells, we iden
Externí odkaz:
https://doaj.org/article/61d09412bf2942f087731239963b50bd
Autor:
Adam A Friedman, Arnaud Amzallag, Iulian Pruteanu-Malinici, Subash Baniya, Zachary A Cooper, Adriano Piris, Leeza Hargreaves, Vivien Igras, Dennie T Frederick, Donald P Lawrence, Daniel A Haber, Keith T Flaherty, Jennifer A Wargo, Sridhar Ramaswamy, Cyril H Benes, David E Fisher
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140310 (2015)
A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses and a sizeable fraction o
Externí odkaz:
https://doaj.org/article/2c65cc61a9ae4bf8a9a2e40f9c38d289
Autor:
Hongjie Li, Gromoslaw A Smolen, Lisa F Beers, Li Xia, William Gerald, Joanne Wang, Daniel A Haber, Sean Bong Lee
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2353 (2008)
BACKGROUND:Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive malignancy that affects mainly adolescents and young adults. A defining characteristic of DSRCT is a specific chromosomal translocation, t(11;22)(p13;q12), that fuses EWS w
Externí odkaz:
https://doaj.org/article/fff09f77a8fc4d81aff73b5b5b448e52
Autor:
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A. Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K. Egan, Ellen Murchie, Michele Ceribelli, Giovanna S. Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L. Boisvert, Leah J. Damon, Kelli M. Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J. Garnett, Jeffrey A. Engelman, Daniel A. Haber, Craig J. Thomas, Eytan Ruppin, Cyril H. Benes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 500
Externí odkaz:
https://doaj.org/article/74d18fafe3754d38962c3b1365fa27b3
Autor:
Douglas B. Fox, Richard Y. Ebright, Xin Hong, Hunter C. Russell, Hongshan Guo, Thomas J. LaSalle, Ben S. Wittner, Nicolas Poux, Joanna A. Vuille, Mehmet Toner, Nir Hacohen, Genevieve M. Boland, Debattama R. Sen, Ryan J. Sullivan, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-7 (2023)
Abstract Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterizatio
Externí odkaz:
https://doaj.org/article/0c4c7c44430b4c2d974ab834570483bb
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Autor:
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112129- (2023)
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influen
Externí odkaz:
https://doaj.org/article/d7cf1d03230041eaa0fc9ddd6ef3a6cf
Autor:
Jon F. Edd, Avanish Mishra, Kyle C. Smith, Ravi Kapur, Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104696- (2022)
Summary: Circulating tumor cells (CTCs) enter the vasculature from solid tumors and disseminate widely to initiate metastases. Mining the metastatic-enriched molecular signatures of CTCs before, during, and after treatment holds unique potential in p
Externí odkaz:
https://doaj.org/article/446f9c3da8774d009700741fdd78d777
Autor:
Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi, Ben S. Wittner, Kira L. Niederhoffer, Linda T. Nieman, Brian Chirn, Devon F. Wiley, Benjamin Wesley, Brian Shaw, Edwin Nieblas-Bedolla, Lian Atlas, Annamaria Szabolcs, Anthony J. Iafrate, Mehmet Toner, David T. Ting, Priscilla K. Brastianos, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic
Externí odkaz:
https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Joseph W. Franses, Julia Philipp, Pavlos Missios, Irun Bhan, Ann Liu, Chittampalli Yashaswini, Eric Tai, Huili Zhu, Matteo Ligorio, Benjamin Nicholson, Elizabeth M. Tassoni, Niyati Desai, Anupriya S. Kulkarni, Annamaria Szabolcs, Theodore S. Hong, Andrew S. Liss, Carlos Fernandez-del Castillo, David P. Ryan, Shyamala Maheswaran, Daniel A. Haber, George Q. Daley, David T. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeu
Externí odkaz:
https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee0