Zobrazeno 1 - 10
of 365
pro vyhledávání: '"Daniel A Beard"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008861 (2021)
The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs. Hypoxic pulmonary vasoconstriction is understood to be the primary active regulator
Externí odkaz:
https://doaj.org/article/76dfa3895c10463eb6305ffeaeb659f3
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005982 (2018)
High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently demonstrated disparities in fuel usage during transient aerobic exercise. HCR rats can maintain fat
Externí odkaz:
https://doaj.org/article/5c768d979759462c826992f0d2602344
Autor:
Ross A Kelly, Joseph Leedale, Andy Harrell, Daniel A Beard, Laura E Randle, Amy E Chadwick, Steven D Webb
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207803 (2018)
Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in order to promote growth, proliferation and longevity. Glycolysis relies upon NAD+ to accept ele
Externí odkaz:
https://doaj.org/article/6175f3db99624567aabd4c19c5b8a565
Autor:
Michael P. Cooreman, Javed Butler, Robert P. Giugliano, Faiez Zannad, Lucile Dzen, Philippe Huot-Marchand, Martine Baudin, Daniel R. Beard, Jean-Louis Junien, Pierre Broqua, Manal F. Abdelmalek, Sven M. Francque
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Lanifibranor, a pan-PPAR agonist, improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH), who have poor cardiometabolic health (CMH) and cardiovascular events as major mortality cause. NATIVE trial
Externí odkaz:
https://doaj.org/article/a8349f7dd9df4b16ac7569db5e4e8c59
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003634 (2014)
Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense resea
Externí odkaz:
https://doaj.org/article/261f1dc6c8c64bf694460bedc44d6ab3
Autor:
Jason N Bazil, Karl D Stamm, Xing Li, Raghuram Thiagarajan, Timothy J Nelson, Aoy Tomita-Mitchell, Daniel A Beard
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100842 (2014)
Cardiac development is a complex, multiscale process encompassing cell fate adoption, differentiation and morphogenesis. To elucidate pathways underlying this process, a recently developed algorithm to reverse engineer gene regulatory networks was ap
Externí odkaz:
https://doaj.org/article/f2d11c0fea7f49fa8e0d7a1c748b0ca2
Autor:
Robert I Menzies, Robert John Unwin, Ranjan K Dash, Daniel A Beard, Allen W Cowley, Brian E Carlson, John J Mullins, Matthew A Bailey
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Reduced glomerular filtration, hypertension and renal microvascular injury are hallmarks of chronic kidney disease, which has a global prevalence of ~10%. We have shown previously shown that the Fischer (F344) rat has lower GFR than the Lewis rat, an
Externí odkaz:
https://doaj.org/article/fce18699015f4cb78b8cc1fcf9132830
Autor:
Dagmar Waltemath, Richard Adams, Daniel A Beard, Frank T Bergmann, Upinder S Bhalla, Randall Britten, Vijayalakshmi Chelliah, Michael T Cooling, Jonathan Cooper, Edmund J Crampin, Alan Garny, Stefan Hoops, Michael Hucka, Peter Hunter, Edda Klipp, Camille Laibe, Andrew K Miller, Ion Moraru, David Nickerson, Poul Nielsen, Macha Nikolski, Sven Sahle, Herbert M Sauro, Henning Schmidt, Jacky L Snoep, Dominic Tolle, Olaf Wolkenhauer, Nicolas Le Novère
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 4, p e1001122 (2011)
Externí odkaz:
https://doaj.org/article/13131c5d4d6c4638ab84981fd5e20ad9
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13278 (2010)
Mitochondrial Ca(2+) uniporter is the primary influx pathway for Ca(2+) into respiring mitochondria, and hence plays a key role in mitochondrial Ca(2+) homeostasis. Though the mechanism of extra-matrix Ca(2+) dependency of mitochondrial Ca(2+) uptake
Externí odkaz:
https://doaj.org/article/bd9fee69923e409e982b032bd156e20b
Autor:
Daniel A Beard, Martin J Kushmerick
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 8, p e1000459 (2009)
Externí odkaz:
https://doaj.org/article/cbb3b5676c93487787a9641418d94dae