Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Daniel A, Portnoy"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids. Antifolate drugs are widely used as broad-spectrum antibiotics for bacterial inf
Externí odkaz:
https://doaj.org/article/141b2593095144fc80533179ad2c9c31
Autor:
Huntly M Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R Johnson, Guillaume R Golovkine, Samantha L Bell, Claire E Dodd, Erik Van Dis, Wandy L Beatty, Shally R Margolis, Teresa Repasy, Isaac Shaker, Angus Y Lee, Russell E Vance, Sarah A Stanley, Robert O Watson, Nevan J Krogan, Daniel A Portnoy, Bennett H Penn, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011088 (2023)
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://doaj.org/article/bb529b2bbf75461d932dc89cb0aeb02a
Autor:
Rafael Rivera-Lugo, Shuo Huang, Frank Lee, Raphaël Méheust, Anthony T. Iavarone, Ashley M. Sidebottom, Eric Oldfield, Daniel A. Portnoy, Samuel H. Light
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT A variety of electron transfer mechanisms link bacterial cytosolic electron pools with functionally diverse redox activities in the cell envelope and extracellular space. In Listeria monocytogenes, the ApbE-like enzyme FmnB catalyzes extracy
Externí odkaz:
https://doaj.org/article/7f74c33962af4e41a4552b9906296863
Autor:
Rafael Rivera-Lugo, David Deng, Andrea Anaya-Sanchez, Sara Tejedor-Sanz, Eugene Tang, Valeria M Reyes Ruiz, Hans B Smith, Denis V Titov, John-Demian Sauer, Eric P Skaar, Caroline M Ajo-Franklin, Daniel A Portnoy, Samuel H Light
Publikováno v:
eLife, Vol 11 (2022)
Cellular respiration is essential for multiple bacterial pathogens and a validated antibiotic target. In addition to driving oxidative phosphorylation, bacterial respiration has a variety of ancillary functions that obscure its contribution to pathog
Externí odkaz:
https://doaj.org/article/b9b31cc173164b79bceb720e420b9aca
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009819 (2021)
Listeria monocytogenes is a Gram-positive, food-borne pathogen that lives a biphasic lifestyle, cycling between the environment and as a facultative intracellular pathogen of mammals. Upon entry into host cells, L. monocytogenes upregulates expressio
Externí odkaz:
https://doaj.org/article/b8a47f2dbf7e4a6bade2e424ac783a34
Autor:
Daisy X Ji, Kristen C Witt, Dmitri I Kotov, Shally R Margolis, Alexander Louie, Victoria Chevée, Katherine J Chen, Moritz M Gaidt, Harmandeep S Dhaliwal, Angus Y Lee, Stephen L Nishimura, Dario S Zamboni, Igor Kramnik, Daniel A Portnoy, K Heran Darwin, Russell E Vance
Publikováno v:
eLife, Vol 10 (2021)
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriatel
Externí odkaz:
https://doaj.org/article/a13a048f3761473cb07137e4ffca8ea4
Autor:
Bret N. Peterson, Megan K. M. Young, Shukun Luo, Jeffrey Wang, Aaron T. Whiteley, Joshua J. Woodward, Liang Tong, Jue D. Wang, Daniel A. Portnoy
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell
Externí odkaz:
https://doaj.org/article/fda165a1b7c14027812eb73e6e1bcba5
Autor:
Brittney N Nguyen, Alfredo Chávez-Arroyo, Mandy I Cheng, Maria Krasilnikov, Alexander Louie, Daniel A Portnoy
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008622 (2020)
Listeria monocytogenes is a facultative intracellular bacterial pathogen that escapes from phagosomes and induces a robust adaptive immune response in mice, while mutants unable to escape phagosomes fail to induce a robust adaptive immune response an
Externí odkaz:
https://doaj.org/article/2c235378adc84da6a9b35bf247455084
Autor:
Erik Van Dis, Kimberly M. Sogi, Chris S. Rae, Kelsey E. Sivick, Natalie H. Surh, Meredith L. Leong, David B. Kanne, Ken Metchette, Justin J. Leong, Jacob R. Bruml, Vivian Chen, Kartoosh Heydari, Nathalie Cadieux, Tom Evans, Sarah M. McWhirter, Thomas W. Dubensky, Jr., Daniel A. Portnoy, Sarah A. Stanley
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1435-1447 (2018)
Summary: There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein su
Externí odkaz:
https://doaj.org/article/5af82e8c90b24ca6bea46b4f64e9ab0e
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Listeria monocytogenes can cause a life-threatening illness when the foodborne pathogen spreads beyond the intestinal tract to distant organs. Many aspects of the intestinal phase of L. monocytogenes pathogenesis remain unknown. Here, we pre
Externí odkaz:
https://doaj.org/article/996b1beff94b476b8164a44aebde9aa6