Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Daniel A, Mordes"'
Autor:
Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C. Thwin, Koli Basu, Matthew D. Callahan, Daniel R. Southworth, Daniel A. Mordes, Charles S. Craik, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho
Externí odkaz:
https://doaj.org/article/65e099c2e88a4ef08f3a505a925ec40b
Autor:
Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010956 (2022)
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkins
Externí odkaz:
https://doaj.org/article/1cc5104ca63749ee94a0198a2fd4598b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Neurodegenerative disorders have been extremely challenging to treat with traditional drug-based approaches and curative therapies are lacking. Given continued progress in stem cell technologies, cell replacement strategies have emerged as concrete a
Externí odkaz:
https://doaj.org/article/15a886fcfde549f8850d8da6529505a0
Autor:
Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Jisoo Lee, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008222 (2020)
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we soug
Externí odkaz:
https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
Autor:
Daniel A. Mordes, Mercedes Prudencio, Lindsey D. Goodman, Joseph R. Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W. Dickson, Rosa Rademakers, Nancy M. Bonini, Leonard Petrucelli, Kevin Eggan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Reduced expression of the C9ORF72 gene product has been propose
Externí odkaz:
https://doaj.org/article/7dff6ba8c98d431088d6dde5e87fa681
Autor:
Feng Tian, Wenlong Yang, Daniel A. Mordes, Jin-Yuan Wang, Johnny S. Salameh, Joanie Mok, Jeannie Chew, Aarti Sharma, Ester Leno-Duran, Satomi Suzuki-Uematsu, Naoki Suzuki, Steve S. Han, Fa-Ke Lu, Minbiao Ji, Rosanna Zhang, Yue Liu, Jack Strominger, Neil A. Shneider, Leonard Petrucelli, X. Sunney Xie, Kevin Eggan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic la
Externí odkaz:
https://doaj.org/article/60127ef2c8cc4a6295abca6013b56613
Autor:
Julie, Smeyers, Daniel A, Mordes
Publikováno v:
Brain. 146:4-5
This scientific commentary refers to ‘Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis’ by Ito et al. (https://doi.org/10.1093/brain/awac306).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac971ed6b9827671ad9a68ae0c547bf
https://doi.org/10.1093/brain/awac408
https://doi.org/10.1093/brain/awac408
Autor:
Sara A. M. Holec, Jisoo Lee, Abby Oehler, Felicia K. Ooi, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner, Amanda L. Woerman
Publikováno v:
Acta neuropathologica. 144(4)
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the α-synuclein gene, SNCA, have been identified as the cause o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d95041af42790fa69600526623f967c
https://pubmed.ncbi.nlm.nih.gov/36018376
https://pubmed.ncbi.nlm.nih.gov/36018376
Autor:
Mark D. Cannon, David A. Owens, Kel Vin Woo, William M. Oldham, Daniel A. Mordes, Kyle O. Arneson, Aubrey A. Hunt, Erin J. Ciampa, Terence S. Dermody
Publikováno v:
Medical Education Online, Vol 16, Iss 0, Pp 1-9 (2011)
Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportun
Externí odkaz:
https://doaj.org/article/399aa090f2654c60b5fb69949ad7b026
Autor:
Steven A. McCarroll, Brian J. Joseph, Inma Cobos, Laura Bortolin, Irena Kadiu, Sulagna Ghosh, Alexander Couto, Aaron Burberry, Daniel Meyer, Kevin Eggan, Olli Pietilainen, Melissa Goldman, Francesco Limone, Beth Stevens, Martine Therrien, Daniel A. Mordes
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterised by a progressive loss of motor function. The eponymous spinal sclerosis observed at autopsy is the result of the degeneration of extratelencephalic neurons, Betz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831769520c89a3efdd9b877e0f309d6
https://doi.org/10.1101/2021.07.12.452054
https://doi.org/10.1101/2021.07.12.452054
