Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daniel K. Cashion"'
Autor:
Tao Jiang, James M. Fujitaki, Daniel K. Cashion, Srinivas Rao Kasibhatla, Yan Liu, K. Raja Reddy, Paul D. van Poelje, Scott C. Potter, Frank Taplin, William G. Schulz, Kevin Fan, Mark D. Erion, Qun Dang
Publikováno v:
Journal of Medicinal Chemistry. 51:4331-4339
Like most phosphonic acids, the recently discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatase (FBPase) exhibited low oral bioavailability (OBAV) and therefore required a prodrug to achieve oral efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bfa7ac815f2145b3a778cc523215b4
https://doi.org/10.1021/jm8001235
https://doi.org/10.1021/jm8001235
Publikováno v:
Tetrahedron Letters. 49:2143-2145
Attempted conversion of 4-chloro-5-(N-4-bromobutanoyl)amino-6-phenethylaminopyrimidine (2) to 6-chloro-8-[1-(3-bromo)propyl]-9-phenethylpurine (1) under standard cyclization conditions did not give the targeted product. Instead, an unexpected cycliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6b203bf4a8a9b7cb57f40466d98464
https://doi.org/10.1016/j.tetlet.2008.01.095
https://doi.org/10.1016/j.tetlet.2008.01.095
Autor:
Jay DaRe, Tao Jiang, Scott C. Potter, Tony Gibson, Qun Dang, Frank Taplin, Yan Liu, Mark D. Erion, Daniel K. Cashion, Haiqing Li, Zhili Sun, Jason D. Jacintho, Paul D. van Poelje, Srinivas Rao Kasibhatla, Yi Fan, Lemus Robert Huerta, Feng Tian, Wenyu Li
Publikováno v:
Journal of medicinal chemistry. 54(1)
Oral delivery of previously disclosed purine and benzimidazole fructose-1,6-bisphosphatase (FBPase) inhibitors via prodrugs failed, which was likely due to their high molecular weight (>600). Therefore, a smaller scaffold was desired, and a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7227453a1b09fd9029c96cde2a01f99
https://pubmed.ncbi.nlm.nih.gov/21126019
https://pubmed.ncbi.nlm.nih.gov/21126019
Autor:
Cheryl D. Stevenson, Daniel K. Cashion
Publikováno v:
The Journal of organic chemistry. 65(22)
(S)-Verbenol was substituted onto cyclooctatetraene (COT) via an ether linkage. In tetrahydrofuran (THF), Cs(+) or Na(+) counterions are tightly ion associated with the verbenoxy-COT dianion. A cosolvent, consisting of an ibuprofen unit connected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfbfcd17cdbdb2c4d1dd0f7b59aca6a
https://pubmed.ncbi.nlm.nih.gov/11076619
https://pubmed.ncbi.nlm.nih.gov/11076619
Autor:
Qun Dang, Yan Liu, Daniel K. Cashion, Srinivas Rao Kasibhatla, Tao Jiang, Frank Taplin, Jason D. Jacintho, Haiqing Li, Zhili Sun, Yi Fan, Jay DaRe, Feng Tian, Wenyu Li, Tony Gibson, Robert Lemus, Paul D. van Poelje, Scott C. Potter, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jan2011, Vol. 54 Issue 1, p153-165, 13p
Autor:
Qun Dang, Srinivas Rao Kasibhatla, Tao Jiang, Kevin Fan, Yan Liu, Frank Taplin, William Schulz, Daniel K. Cashion, K. Raja Reddy, Paul D. van Poelje, James M. Fujitaki, Scott C. Potter, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jun2008, Vol. 51 Issue 14, p4331-4339, 9p