Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Daniel, Sobral"'
For years, the cosmological constant $\Lambda$ and cold dark matter (CDM) model ($\Lambda\text{CDM}$) has stood as a cornerstone in modern cosmology and serves as the predominant theoretical framework for current and forthcoming surveys. However, the
Externí odkaz:
http://arxiv.org/abs/2409.15170
Autor:
Rion Brattig-Correia, Joana M Almeida, Margot Julia Wyrwoll, Irene Julca, Daniel Sobral, Chandra Shekhar Misra, Sara Di Persio, Leonardo Gastón Guilgur, Hans-Christian Schuppe, Neide Silva, Pedro Prudêncio, Ana Nóvoa, Ana S Leocádio, Joana Bom, Sandra Laurentino, Moises Mallo, Sabine Kliesch, Marek Mutwil, Luis M Rocha, Frank Tüttelmann, Jörg D Becker, Paulo Navarro-Costa
Publikováno v:
eLife, Vol 13 (2024)
Male germ cells share a common origin across animal species, therefore they likely retain a conserved genetic program that defines their cellular identity. However, the unique evolutionary dynamics of male germ cells coupled with their widespread lea
Externí odkaz:
https://doaj.org/article/2abf73b38c2f4697a2904a171653c40a
Autor:
João Dourado Santos, Daniel Sobral, Miguel Pinheiro, Joana Isidro, Carlijn Bogaardt, Miguel Pinto, Rodrigo Eusébio, André Santos, Rafael Mamede, Daniel L. Horton, João Paulo Gomes, TELEVIR Consortium, Vítor Borges
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Implementation of clinical metagenomics and pathogen genomic surveillance can be particularly challenging due to the lack of bioinformatics tools and/or expertise. In order to face this challenge, we have previously developed INSa
Externí odkaz:
https://doaj.org/article/aa22a43105d24f1a9b36e3e321475aae
Autor:
Rita Cordeiro, Constantino P. Caetano, Daniel Sobral, Rita Ferreira, Luís Coelho, Ana Pelerito, Isabel Lopes de Carvalho, Sónia Namorado, Dinis B. Loyens, Ricardo Mexia, Cândida Fernandes, José Miguel Neves, Ana Luísa João, Miguel Rocha, Luís Miguel Duque, Inês Correia, Teresa Baptista, Cláudia Brazão, Diogo Sousa, Paulo Filipe, Miguel Alpalhão, Fernando Maltez, Diana Póvoas, Raquel Pinto, João Caria, Rita Patrocínio de Jesus, Patrícia Pacheco, Francesca Peruzzu, Josefina Méndez, Luís Ferreira, Kamal Mansinho, João Vaz Alves, Joana Vasconcelos, João Domingos, Sara Casanova, Frederico Duarte, Maria João Gonçalves, Mafalda Brito Salvador, Mafalda Andresen Guimarães, Sueila Martins, Marvin Silva Oliveira, Daniela Santos, Luís Vieira, Maria Sofia Núncio, Vítor Borges, João Paulo Gomes
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
In 2023, a second wave of the global mpox epidemic, which is mainly affecting men who have sex with men (MSM), was observed in some countries. Herein, we benefited from a large viral sequence sampling (76/121; 63%) and vast epidemiological data to ch
Externí odkaz:
https://doaj.org/article/61c51d32e2de4877b20d820388104c9b
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Transcription termination is a crucial step in the production of conforming mRNAs and functional proteins. Under cellular stress conditions, the transcription machinery fails to identify the termination site and continues transcribing beyond
Externí odkaz:
https://doaj.org/article/86bc885d045e4c8194b1572f2a5af2be
Autor:
Verónica Mixão, Miguel Pinto, Daniel Sobral, Adriano Di Pasquale, João Paulo Gomes, Vítor Borges
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Genomics-informed pathogen surveillance strengthens public health decision-making, playing an important role in infectious diseases’ prevention and control. A pivotal outcome of genomics surveillance is the identification of pat
Externí odkaz:
https://doaj.org/article/864de65eb9b24deeb4602c48cd8b88f1
Autor:
Andreia Fiúza Ribeiro, Ana Laura Fitas, Marcela Oliveira Pires, Paula Matoso, Dário Ligeiro, Daniel Sobral, Carlos Penha-Gonçalves, Jocelyne Demengeot, Íris Caramalho, Catarina Limbert
Publikováno v:
Journal of Diabetes Research, Vol 2024 (2024)
Conclusions: WES found potentially deleterious rare variants in MODY genes in 8.1% of EOT1D, occurring in the context of a T1D genetic background. Such genetic variants may contribute to disease precipitation by a β-cell dysfunction mechanism. This
Externí odkaz:
https://doaj.org/article/b2777bfd09e14d60ba14bbb7d23120ce
Autor:
Iris Caramalho, Paula Matoso, Dário Ligeiro, Tiago Paixão, Daniel Sobral, Ana Laura Fitas, Catarina Limbert, Jocelyne Demengeot, Carlos Penha-Gonçalves
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionEarly-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen (HLA) and non-HLA variants contribute to age at T1D diagnosis, detailed analyses
Externí odkaz:
https://doaj.org/article/9c2c31772930482bbe946e8a148ecbe3
Autor:
Irina Kislaya, Pedro Casaca, Vítor Borges, Carlos Sousa, Bibiana I. Ferreira, Ana Fonte, Eugénia Fernandes, Carlos Matias Dias, Sílvia Duarte, José Pedro Almeida, Inês Grenho, Luís Coelho, Rita Ferreira, Patrícia Pita Ferreira, Cláudia Medeiros Borges, Joana Isidro, Miguel Pinto, Luís Menezes, Daniel Sobral, Alexandra Nunes, Daniela Santos, António Maia Gonçalves, Luís Vieira, João Paulo Gomes, Pedro Pinto Leite, Baltazar Nunes, Ausenda Machado, André Peralta-Santos
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 3, Pp 569-575 (2023)
We estimated comparative primary and booster vaccine effectiveness (VE) of SARS-CoV-2 Omicron BA.5 and BA.2 lineages against infection and disease progression. During April–June 2022, we implemented a case–case and cohort study and classified lin
Externí odkaz:
https://doaj.org/article/b82cec60f46c425ca871c7c22b38c0de
Autor:
Daniel Sobral, Ana Filipa Fernandes, Miguel Bernardes, Patrícia Pinto, Helena Santos, João Lagoas-Gomes, José Tavares-Costa, José A. P. Silva, João Madruga Dias, Alexandra Bernardo, Jean-Charles Gaillard, Jean Armengaud, Vladimir Benes, Lúcia Domingues, Sara Maia, Jaime C. Branco, Ana Varela Coelho, Fernando M. Pimentel-Santos
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 382 (2024)
This study aims at identifying molecular biomarkers differentiating responders and non-responders to treatment with Tumor Necrosis Factor inhibitors (TNFi) among patients with axial spondyloarthritis (axSpA). Whole blood mRNA and plasma proteins were
Externí odkaz:
https://doaj.org/article/1ce5cc21929546879b104f7e022fd28b