Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Daniel, Schrimpf"'
Autor:
Jürgen Hench, Claus Hultschig, Jon Brugger, Luigi Mariani, Raphael Guzman, Jehuda Soleman, Severina Leu, Miles Benton, Irenäus Maria Stec, Ivana Bratic Hench, Per Hoffmann, Patrick Harter, Katharina J Weber, Anne Albers, Christian Thomas, Martin Hasselblatt, Ulrich Schüller, Lisa Restelli, David Capper, Ekkehard Hewer, Joachim Diebold, Danijela Kolenc, Ulf C. Schneider, Elisabeth Rushing, Rosa della Monica, Lorenzo Chiariotti, Martin Sill, Daniel Schrimpf, Andreas von Deimling, Felix Sahm, Christian Kölsche, Markus Tolnay, Stephan Frank
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour typing with unprecedented precision, has quickly become a new standard of care. Whereas genome-wide diagnostic me
Externí odkaz:
https://doaj.org/article/0728b5481b5942bf8a38046de711832e
Autor:
Katharina Sahm, Tobias Kessler, Philipp Eisele, Miriam Ratliff, Elena Sperk, Laila König, Michael O. Breckwoldt, Corinna Seliger, Iris Mildenberger, Daniel Schrimpf, Christel Herold-Mende, Pia S. Zeiner, Ghazaleh Tabatabai, Sven G. Meuth, David Capper, Martin Bendszus, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-9 (2023)
Abstract Background Concurrent malignant brain tumors in patients with multiple sclerosis (MS) constitute a rare but paradigmatic phenomenon for studying neuroimmunological mechanisms from both molecular and clinical perspectives. Methods A multicent
Externí odkaz:
https://doaj.org/article/85b83cf8178849efa2c0227482eb36de
Autor:
David E. Reuss, Daniel Schrimpf, Asan Cherkezov, Abigail K. Suwala, Tereza Lausová, Matija Snuderl, David Capper, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling
Publikováno v:
Free Neuropathology, Vol 5 (2024)
The morphological patterns leading to the diagnosis of glioblastoma may also commonly be observed in several other distinct tumor entities, which can result in a mixed bag of tumors subsumed under this diagnosis. The 2021 WHO Classification of CNS Tu
Externí odkaz:
https://doaj.org/article/ec08a5df12b84342a99e3ace789f3936
Autor:
David E. Reuss, Daniel Schrimpf, Damian Stichel, Azadeh Ebrahimi, Chris Dampier, Kenneth Aldape, Matija Snuderl, David Capper, Martin Sill, David T.W. Jones, Stefan M. Pfister, Sahm Felix, Andreas von Deimling
Publikováno v:
Free Neuropathology, Vol 4 (2023)
Pleomorphic xanthoastrocytoma (PXA) poses a diagnostic challenge. The present study relies on methylation-based predictions and focuses on copy number variations (CNV) in PXA. We identified 551 tumors from patients having received the histologic diag
Externí odkaz:
https://doaj.org/article/f8908d90e3994b21b1f5c4eda0281d53
Autor:
Philipp Sievers, Martin Sill, Daniel Schrimpf, Zied Abdullaev, Andrew M. Donson, Jessica A. Lake, Dennis Friedel, David Scheie, Olli Tynninen, Tuomas Rauramaa, Kaisa L. Vepsäläinen, David Samuel, Rebecca Chapman, Richard G. Grundy, Kristian W. Pajtler, Arnault Tauziède-Espariat, Alice Métais, Pascale Varlet, Matija Snuderl, Thomas S. Jacques, Kenneth Aldape, David E. Reuss, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, Felix Sahm, David T. W. Jones
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Pediatric neoplasms in the central nervous system (CNS) show extensive clinical and molecular heterogeneity and are fundamentally different from those occurring in adults. Molecular genetic testing contributes to accurate diagnosis and enabl
Externí odkaz:
https://doaj.org/article/9f54e4ebe7994704862580e7e4db4d5b
Autor:
Felix K. F. Kommoss, Anne-Sophie Chong, Anne-Laure Chong, Elke Pfaff, David T. W. Jones, Laura S. Hiemcke-Jiwa, Lennart A. Kester, Uta Flucke, Manfred Gessler, Daniel Schrimpf, Felix Sahm, Blaise A. Clarke, Colin J. R. Stewart, Yemin Wang, C. Blake Gilks, Friedrich Kommoss, David G. Huntsman, Ulrich Schüller, Christian Koelsche, W. Glenn McCluggage, Andreas von Deimling, William D. Foulkes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations.
Externí odkaz:
https://doaj.org/article/a05486ab7360425590af6bdea112612d
Autor:
Konstantin Okonechnikov, Aniello Federico, Daniel Schrimpf, Philipp Sievers, Felix Sahm, Jan Koster, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Nowadays medulloblastoma (MB) tumors can be treated with risk-stratified approaches with up to 80% success rate. However, disease relapses occur in approximately 30% of patients and successful salvage treatment strategies at relapse remain s
Externí odkaz:
https://doaj.org/article/0289bf3c012b4571ab30fae8f9253fa0
Autor:
Azadeh Ebrahimi, Andrey Korshunov, Guido Reifenberger, David Capper, Joerg Felsberg, Elena Trisolini, Bianca Pollo, Chiara Calatozzolo, Marco Prinz, Ori Staszewski, Leonille Schweizer, Jens Schittenhelm, Patrick N. Harter, Werner Paulus, Christian Thomas, Patricia Kohlhof-Meinecke, Marcel Seiz-Rosenhagen, Till Milde, Belén M. Casalini, Abigail Suwala, Annika K. Wefers, Annekathrin Reinhardt, Philipp Sievers, Christof M. Kramm, Nima Etminam, Andreas Unterberg, Wolfgang Wick, Christel Herold-Mende, Dominik Sturm, Stefan M. Pfister, Martin Sill, David T. W. Jones, Daniel Schrimpf, David E. Reuss, Ken Aldape, Zied Abdullaev, Felix Sahm, Andreas von Deimling, Damian Stichel
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-10 (2022)
Abstract Pleomorphic xanthoastrocytoma (PXA) in its classic manifestation exhibits distinct morphological features and is assigned to CNS WHO grade 2 or grade 3. Distinction from glioblastoma variants and lower grade glial and glioneuronal tumors is
Externí odkaz:
https://doaj.org/article/3e45563738ca4626aad3e030dbd8c07b
Autor:
Iben Lyskjær, Solange De Noon, Roberto Tirabosco, Ana Maia Rocha, Daniel Lindsay, Fernanda Amary, Hongtao Ye, Daniel Schrimpf, Damian Stichel, Martin Sill, Christian Koelsche, Nischalan Pillay, Andreas Von Deimling, Stephan Beck, Adrienne M Flanagan
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 4, Pp 350-360 (2021)
Abstract Diagnosing bone and soft tissue neoplasms remains challenging because of the large number of subtypes, many of which lack diagnostic biomarkers. DNA methylation profiles have proven to be a reliable basis for the classification of brain tumo
Externí odkaz:
https://doaj.org/article/87eeef613a0246759dc48aec933731e8
Autor:
Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David E. Reuss, Philipp Sievers, Abigail Kora Suwala, Ella Kumirova, Olga Zheludkova, Andrey Golanov, David T. W. Jones, Stefan M. Pfister, Marcel Kool, Andreas von Deimling
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS
Externí odkaz:
https://doaj.org/article/a03757785fc54aa38022bafffc802d35