Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Daniel, Roybal"'
Autor:
Jeffrey Abrams, Daniel Roybal, Nourdine Chakouri, Alexander N. Katchman, Richard Weinberg, Lin Yang, Bi-xing Chen, Sergey I. Zakharov, Jessica A. Hennessey, Uma Mahesh R. Avula, Johanna Diaz, Chaojian Wang, Elaine Y. Wan, Geoffrey S. Pitt, Manu Ben-Johny, Steven O. Marx
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
The Ca2+-binding protein calmodulin has emerged as a pivotal player in tuning Na+ channel function, although its impact in vivo remains to be resolved. Here, we identify the role of calmodulin and the NaV1.5 interactome in regulating late Na+ current
Externí odkaz:
https://doaj.org/article/efe44da0f05e4c1a960d684f11a8834d
Autor:
Nourdine Chakouri, Sharen Rivas, Daniel Roybal, Lin Yang, Johanna Diaz, Allen L. Hsu, Ryan Mahling, Bi-Xing Chen, Josiah O. Owoyemi, Deborah DiSilvestre, Dario Sirabella, Barbara Corneo, Gordon F. Tomaselli, Ivy E. Dick, Steven O. Marx, Manu Ben-Johny
Publikováno v:
Nature Cardiovascular Research. 1:1-13
Voltage-gated sodium (Nav1.5) channels support the genesis and brisk spatial propagation of action potentials in the heart. Disruption of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6202b05b9c6c44ffd2b3018df2302818
https://doi.org/10.1038/s44161-022-00060-6
https://doi.org/10.1038/s44161-022-00060-6
Autor:
Stephen Leong, Guoxia Liu, Manu Ben-Johny, Veli K. Topkara, Xianghai Liao, Bi-Xing Chen, Steven O. Marx, Sergey I. Zakharov, Daniel Roybal, Geoffrey S. Pitt, Lin Yang, Oliver B. Clarke, Pedro J. del Rivero Morfin, Ree Lu, Henry M. Colecraft, Johanna Diaz, Alexander Katchman, Jared Kushner, Arianne Papa, Jessica A. Hennessey
Publikováno v:
Circulation Research. 128:76-88
Rationale: Changing activity of cardiac Ca V 1.2 channels under basal conditions, during sympathetic activation, and in heart failure is a major determinant of cardiac physiology and pathophysiology. Although cardiac Ca V 1.2 channels are prominently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fcbcdc969b7a4a853612b7a86fda9bc
https://doi.org/10.1161/circresaha.120.317839
https://doi.org/10.1161/circresaha.120.317839
Publikováno v:
Channels
Activation of protein kinase A by cyclic AMP results in a multi-fold upregulation of CaV1.2 currents in the heart, as originally reported in the 1970's and 1980's. Despite considerable interest and much investment, the molecular mechanisms responsibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b7041c002ed97a3181a88d1ab4a3b8
http://europepmc.org/articles/PMC7153787
http://europepmc.org/articles/PMC7153787
Autor:
Alexander Kushnir, Jared Kushner, Geoffrey S. Pitt, Daniel Roybal, Steven P. Gygi, Steven O. Marx, Guoxia Liu, Manu Ben-Johny, Katerina Dangas, Bi-xing Chen, Jessica A. Hennessey, Lin Yang, Alexander Katchman, Arianne Papa, Marian Kalocsay, Henry M. Colecraft, Sergey I. Zakharov
Publikováno v:
Nature
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of CaV1.2 voltage-gated calcium channels1–4. However, this augmentation persists in transgenic murine hearts expressing mutant CaV1.2 α1C a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a7562d1d5fc478906e74fc93da4eb
http://europepmc.org/articles/PMC7018383
http://europepmc.org/articles/PMC7018383
Autor:
Arianne, Papa, Jared, Kushner, Jessica A, Hennessey, Alexander N, Katchman, Sergey I, Zakharov, Bi-Xing, Chen, Lin, Yang, Ree, Lu, Stephen, Leong, Johanna, Diaz, Guoxia, Liu, Daniel, Roybal, Xianghai, Liao, Pedro J, Del Rivero Morfin, Henry M, Colecraft, Geoffrey S, Pitt, Oliver, Clarke, Veli, Topkara, Manu, Ben-Johny, Steven O, Marx
Publikováno v:
Circ Res
Changing activity of cardiac CaThe primary goal of this study was to determine how various factors converging at the CaWe generated transgenic mice with expression of CaCa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280547c4f9795c98cf9248a4698ec029
https://pubmed.ncbi.nlm.nih.gov/33411632
https://pubmed.ncbi.nlm.nih.gov/33411632
Autor:
Sergey I. Zakharov, Jessica A. Hennessey, Jeffrey Abrams, Chaojian Wang, Geoffrey S. Pitt, Alexander Katchman, Elaine Wan, Johanna Diaz, Uma Mahesh R. Avula, Daniel Roybal, Nourdine Chakouri, Bi-xing Chen, Lin Yang, Manu Ben-Johny, Richard Weinberg, Steven O. Marx
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 19 (2020)
JCI Insight, Vol 5, Iss 19 (2020)
The Ca2+-binding protein calmodulin has emerged as a pivotal player in tuning Na+ channel function, although its impact in vivo remains to be resolved. Here, we identify the role of calmodulin and the NaV1.5 interactome in regulating late Na+ current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060fbd90a95a6590aa8bff0a8f04b1ba
https://doi.org/10.1172/jci.insight.141736
https://doi.org/10.1172/jci.insight.141736
Autor:
Nourdine Chakouri, Sharen Rivas, Johanna Diaz, Daniel Roybal, Lin Yang, Bi-xing Chen, Josiah O. Owoyemi, Ivy E. Dick, Gordon F. Tomaselli, Steven O. Marx, Manu Ben-Johny
Publikováno v:
Biophysical Journal. 121:93a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3daf67464ea50489f989b3ebce203a
https://doi.org/10.1016/j.bpj.2021.11.2241
https://doi.org/10.1016/j.bpj.2021.11.2241
Autor:
Steven O. Marx, Elaine Wan, Deepak Saluja, Marc Waase, Jeffrey Abrams, Uma Mahesh R. Avula, Alexander Katchman, Andrew R. Marks, Hasan Garan, Sergey Mironov, Anirudh Gorti, Joseph Bayne, Vivek Iyer, Lin Yang, Edward J. Ciaccio, Daniel Roybal, Sergey I. Zakharov
Publikováno v:
JCI Insight. 4
Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity and mortality. Recently, we created a mouse model with spontaneous and sustained AF caused by a mutation in the Na(V)1.5 channel (F1759A) that enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77186b04ca8d0e5b9badefa19e4ce8a
https://doi.org/10.1172/jci.insight.128765
https://doi.org/10.1172/jci.insight.128765
Autor:
Arianne Papa, Guoxia Liu, Steven O. Marx, Jared Kushner, Bi-xing Chen, Daniel Roybal, Zunaira Shuja, Sergey I. Zakharov, Alexander Kushnir, Lin Yang, Henry M. Colecraft, Prakash Subramanyam, Alexander Katchman, Geoffrey S. Pitt
Ca(2+) channel β-subunit interactions with pore-forming α-subunits are long-thought to be obligatory for channel trafficking to the cell surface and for tuning of basal biophysical properties in many tissues. Unexpectedly, we demonstrate that trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaf9b797a34f211a4bf9856c76a67f7
https://europepmc.org/articles/PMC6355231/
https://europepmc.org/articles/PMC6355231/
