Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Daniel, Ricklin"'
Autor:
Anna E. van Beek, Hannah Jeanguenat, Cécile Häberli, Richard B. Pouw, Christina Lamers, Gábor Pál, Péter Gál, Christoph Q. Schmidt, Daniel Ricklin, Jennifer Keiser
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomes are highly efficient evaders of human immunity, as evident by their ability to survive in human blood for years. How they protect themselves against the constant attack by a key element of innate immunity, the complement system
Externí odkaz:
https://doaj.org/article/57c8f723b6b34a32a74928707eb54f8b
Autor:
Murielle Golomingi, Jessie Kohler, Christina Lamers, Richard B. Pouw, Daniel Ricklin, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Arthur Dopler, Christoph Q. Schmidt, Elaissa Trybus Hardy, Wilbur Lam, Verena Schroeder
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothromb
Externí odkaz:
https://doaj.org/article/6f75ad8a067c46fa8645d29059b9d3be
Autor:
Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen
Externí odkaz:
https://doaj.org/article/0c7331cff4f34721b958795607a6055b
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 495-499 (2021)
Among the many molecular entities suitable for therapeutic use, peptides have emerged as a particularly attractive option for academic drug discovery and development. Their modular structure and extendibility, the availability of powerful and afforda
Externí odkaz:
https://doaj.org/article/e4722846a5e24cce8e8b18bdc5ff967a
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 5, Pp n/a-n/a (2022)
Abstract Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen. However, the function of the excess free FXIII‐B circulating in p
Externí odkaz:
https://doaj.org/article/a3ea7e83cc12424f8414b1c5a0dc45e1
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The β2-integrin receptor family has a broad spectrum of physiological functions ranging from leukocyte adhesion, cell migration, activation, and communication to the phagocytic uptake of cells and particles. Among the members of this family, complem
Externí odkaz:
https://doaj.org/article/fd488ff6a22546e6a0dae666ec9bf211
Autor:
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remo
Externí odkaz:
https://doaj.org/article/b93f354ac6754ce79b8066b0a202bbc6
Autor:
Monica M. Olcina, Ryan K. Kim, Nikolas G. Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G. Graeber, Daniel Ricklin, Manuel Stucki, Amato J. Giaccia
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594- (2020)
Summary: The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and i
Externí odkaz:
https://doaj.org/article/64c2b7db01984770a3fda8aeaa8c2c2f
Autor:
Inge Baas, Laura Delvasto-Nuñez, Peter Ligthart, Conny Brouwer, Claudia Folman, Edimara S. Reis, Daniel Ricklin, John D. Lambris, Diana Wouters, Masja de Haas, Ilse Jongerius, Sacha S. Zeerleder
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/080d337720a34853a8f979a034075c99
Autor:
Elisabetta Lombardi, Alessandro Matte, Antonio M. Risitano, Daniel Ricklin, John D. Lambris, Denise De Zanet, Sakari T. Jokiranta, Nicola Martinelli, Cinzia Scambi, Gianluca Salvagno, Zeno Bisoffi, Chiara Colato, Angela Siciliano, Oscar Bortolami, Mario Mazzuccato, Francesco Zorzi, Luigi De Marco, Lucia De Franceschi
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide distribution. Growing evidence suggests a possible involvement of complement activation in the severity of clinical complications of sickle cell disease. In this
Externí odkaz:
https://doaj.org/article/6802efbe1a4e40d2b8853cc32fab4ed5