Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Daniel, Nettersheim"'
Autor:
Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) that displayed a strong apoptotic potential in Jurkat l
Externí odkaz:
https://doaj.org/article/bb0b5a2076ab4d3192f705aa5b86dbd2
Autor:
Gamal A. Wakileh, Philipp Bierholz, Mara Kotthoff, Margaretha A. Skowron, Felix Bremmer, Alexa Stephan, Stephanie M. Anbuhl, Raimond Heukers, Martine J. Smit, Philipp Ströbel, Daniel Nettersheim
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2023)
Abstract Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, migration, and metastasis. The interaction between CXCL12, secreted by cells from the microenvironment, and its receptors is complex and
Externí odkaz:
https://doaj.org/article/7c03766aefb5452d89e9a05381e22674
Autor:
Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Küffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Ströbel, Kai Stühler, Daniel Nettersheim
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-15 (2023)
Abstract Background Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) com
Externí odkaz:
https://doaj.org/article/caf7ef9e806d4a1ba23d65a22dace983
Autor:
Margaretha A. Skowron, Katharina Eul, Alexa Stephan, Gillian F. Ludwig, Gamal A. Wakileh, Arthur Bister, Christian Söhngen, Katharina Raba, Patrick Petzsch, Gereon Poschmann, Edmund Osei Kuffour, Daniel Degrandi, Shafaqat Ali, Constanze Wiek, Helmut Hanenberg, Carsten Münk, Kai Stühler, Karl Köhrer, Elvira Mass, Daniel Nettersheim
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3107-3127 (2022)
The tumor microenvironment (TM), consisting of the extracellular matrix (ECM), fibroblasts, endothelial cells, and immune cells, might affect tumor invasiveness and the outcome of standard chemotherapy. This study investigated the cross talk between
Externí odkaz:
https://doaj.org/article/ffe3528d607a4047bb2b60d1084aaa8d
Autor:
Margaretha A. Skowron, Teresa K. Becker, Lukas Kurz, Sina Jostes, Felix Bremmer, Florian Fronhoffs, Kai Funke, Gamal A. Wakileh, Melanie R. Müller, Aaron Burmeister, Thomas Lenz, Anja Stefanski, Kai Stühler, Patrick Petzsch, Karl Köhrer, Peter Altevogt, Peter Albers, Glen Kristiansen, Hubert Schorle, Daniel Nettersheim
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 982-1008 (2022)
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluri
Externí odkaz:
https://doaj.org/article/8b019692a23e4a8fbca36ce693337779
Autor:
Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ cell development. The recent and expanding field of RNA modifications is being increasingly implicated in such molecular events, as well a
Externí odkaz:
https://doaj.org/article/a7363cbfa25843038c4292ef51b2d603
Autor:
Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valérie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schröck, Martin Bergmann, Sabine Kliesch, Monika Kressin, Rajkumar Savai
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 731-742 (2021)
Germ cell neoplasia in situ (GCNIS) is the noninvasive precursor of testicular germ cell tumors type II, the most common cancer in young men, which originates from embryonic germ cells blocked in their maturation. GCNIS is associated with impaired Se
Externí odkaz:
https://doaj.org/article/2eeffefdcd874ae3b7d3662678c9baf0
Publikováno v:
Asian Journal of Urology, Vol 8, Iss 2, Pp 144-154 (2021)
The development of germ cell tumors (GCTs) is a unique pathogenesis occurring at an early developmental stage during specification, migration or colonization of primordial germ cells (PGCs) in the genital ridge. Since driver mutations could not be id
Externí odkaz:
https://doaj.org/article/2c41ece1157348d291b2116f52eea554
Publikováno v:
Die Pathologie. 43:409-415
Autor:
Christian Söhngen, David J. Thomas, Margaretha A. Skowron, Felix Bremmer, Markus Eckstein, Anja Stefanski, Marc D. Driessen, Gamal A. Wakileh, Kai Stühler, Peter Altevogt, Dan Theodorescu, Rüdiger Klapdor, Axel Schambach, Daniel Nettersheim
Publikováno v:
The FEBS Journal.