Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel, Meibom"'
Autor:
Daniel Meibom, Jutta Meyer, Clemens-Jeremias von Buehler, Karl D. Collins, Stefanie Maassen, Kersten Matthias Gericke, Jörg Hüser, Joachim Mittendorf, Nuria Ortega Hernandez, Jens Schamberger, Jan Stampfuss, Alexander Straub, Afra Torge, Norbert Witowski, Frank Wunder
Publikováno v:
Journal of Medicinal Chemistry. 66:4659-4670
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237ca05b85c7ada3d8c368e6049cfd97
https://doi.org/10.1021/acs.jmedchem.2c01690
https://doi.org/10.1021/acs.jmedchem.2c01690
Autor:
Daniel Meibom, Sina Micus, Anna Lena Andreevski, Sonja Anlauf, Pamela Bogner, Clemens-Jeremias von Buehler, André P. Dieskau, Jan Dreher, Frank Eitner, Daniela Fliegner, Markus Follmann, Kersten Matthias Gericke, Stefanie Maassen, Jutta Meyer, Karl-Heinz Schlemmer, Holger Steuber, Adrian Tersteegen, Frank Wunder
Publikováno v:
Journal of medicinal chemistry. 65(24)
Despite advances in the treatment of heart failure in recent years, options for patients are still limited and the disease is associated with considerable morbidity and mortality. Modulating cyclic guanosine monophosphate levels within the natriureti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd16e1f51217c135f84e93d9c54be1d
https://pubmed.ncbi.nlm.nih.gov/36475653
https://pubmed.ncbi.nlm.nih.gov/36475653
Autor:
Vasanthanathan Poongavanam, Florian Kölling, Anja Giese, Andreas H. Göller, Lutz Lehmann, Daniel Meibom, Jan Kihlberg
Approaches for predicting proteolysis targeting chimera (PROTAC) cell permeability are of major interest to reduce resource-demanding synthesis and testing of low-permeable PROTACs. We report a comprehensive investigation of the scope and limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a5a5c8aa015b156a0550d40eb03f06
https://doi.org/10.26434/chemrxiv-2022-jmx90
https://doi.org/10.26434/chemrxiv-2022-jmx90
Autor:
Vasanthanathan Poongavanam, Yoseph Atilaw, Stephan Siegel, Anja Giese, Lutz Lehmann, Daniel Meibom, Mate Erdelyi, Jan Kihlberg
Publikováno v:
Journal of medicinal chemistry. 65(19)
Proteolysis-targeting chimeras (PROTACs) must be cell permeable to reach their target proteins. This is challenging as the bivalent structure of PROTACs puts them in chemical space at, or beyond, the outer limits of oral druggable space. We used NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc64d77a165ed274085531aa7577301e
https://pubmed.ncbi.nlm.nih.gov/36170570
https://pubmed.ncbi.nlm.nih.gov/36170570
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3bcb4904153e431b637e901e8f4428
https://doi.org/10.1021/acs.jmedchem.0c00834
https://doi.org/10.1021/acs.jmedchem.0c00834
Publikováno v:
ARKIVOC, Vol 2004, Iss 2, Pp 4-23 (2003)
Externí odkaz:
https://doaj.org/article/cffd97dab26e47e0b34663c055c3c34f
Autor:
Caroline Svensson Nilsson, Jan Kihlberg, Anja Giese, Daniel Meibom, Yoseph Atilaw, Duy Nguyen, Máté Erdélyi, Vasanthanathan Poongavanam
Publikováno v:
ACS Medicinal Chemistry Letters
Proteolysis targeting chimeras (PROTACs) induce intracellular degradation of target proteins. Their bifunctional structure puts degraders in a chemical space where ADME properties often complicate drug discovery. Herein we provide the first structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa5beab47e155db48e78e8af54116a1
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433018
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433018
Autor:
Katja Zimmermann, Nicole Diedrichs, Walter Hübsch, Alexandros Vakalopoulos, Hans-Georg Lerchen, Thomas Kramer, Frank Süssmeier, Barbara Albrecht-Küpper, Raimund Kast, Ursula Krenz, Daniel Meibom, Peter G. Nell, Joachim Mittendorf
Publikováno v:
ChemMedChem. 12:728-737
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980d62cd9e6ae9380c0011ac41a9a756
https://doi.org/10.1002/cmdc.201700151
https://doi.org/10.1002/cmdc.201700151
Autor:
Michael, Härter, Bernd, Kalthof, Martina, Delbeck, Klemens, Lustig, Michael, Gerisch, Simone, Schulz, Raimund, Kast, Daniel, Meibom, Niels, Lindner
Publikováno v:
European journal of medicinal chemistry. 163
The A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71ef3f458da04ccb9b14f430596f21a3
https://pubmed.ncbi.nlm.nih.gov/30576906
https://pubmed.ncbi.nlm.nih.gov/30576906
Autor:
Daniel Meibom, C Grah, J Stampfuss, N A Scheerer, Ming Wu, T Janssens, Piet Claus, Hilde Gillijns, S Moosmang, J Meyer, Stefan Janssens
Publikováno v:
European Heart Journal. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2af70fe9043ce911e7f95d405b88e1
https://doi.org/10.1093/eurheartj/ehy566.p6416
https://doi.org/10.1093/eurheartj/ehy566.p6416