Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Daniel, Kirchhofer"'
Autor:
Yanjie Li, Yuehua Wei, Mark Ultsch, Wei Li, Wanjian Tang, Benjamin Tombling, Xinxin Gao, Yoana Dimitrova, Christian Gampe, Jakob Fuhrmann, Yingnan Zhang, Rami N. Hannoush, Daniel Kirchhofer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a scaffold to construct phage-displayed CKP libraries and subseq
Externí odkaz:
https://doaj.org/article/11f73166b3ab4e1eb0a08d5e402e1864
Autor:
Denis Belitškin, Pauliina Munne, Shishir M. Pant, Johanna M. Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 547-561 (2024)
Hepsin, a type II transmembrane serine protease, is commonly overexpressed in prostate and breast cancer. The hepsin protein is stabilized by the Ras‐MAPK pathway, and, downstream, this protease regulates the degradation of extracellular matrix com
Externí odkaz:
https://doaj.org/article/3e25433eb30948a582897944f0e227ae
Autor:
Lijuan Zhou, Fei Cai, Yanjie Li, Xinxin Gao, Yuehua Wei, Anna Fedorova, Daniel Kirchhofer, Rami N Hannoush, Yingnan Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0300135 (2024)
Peptides present an alternative modality to immunoglobulin domains or small molecules for developing therapeutics to either agonize or antagonize cellular pathways associated with diseases. However, peptides often suffer from poor chemical and physic
Externí odkaz:
https://doaj.org/article/875d8e01b17d45da81fe8d488c49ed25
Autor:
Stefan Gerhardy, Mark Ultsch, Wanjian Tang, Evan Green, Jeffrey K. Holden, Wei Li, Alberto Estevez, Chris Arthur, Irene Tom, Alexis Rohou, Daniel Kirchhofer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The protease HTRA1 is a genetic risk factor for geographic atrophy. Here, Gerhardy et al. describe its inhibition by a clinical Fab, whose binding locks it in an inactive state. The mechanism identifies an essential function of LoopA with this protea
Externí odkaz:
https://doaj.org/article/55461e6817b145b7b4f3d1b202ec723c
Autor:
Mark Ultsch, Michael J. Holliday, Stefan Gerhardy, Paul Moran, Suzie J. Scales, Nidhi Gupta, Francesca Oltrabella, Cecilia Chiu, Wayne Fairbrother, Charles Eigenbrot, Daniel Kirchhofer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Mark Ultsch et al. report X-ray and NMR structures of the N-terminal domain of two closely related innate immunity proteins, ApoL1 and ApoL2. Their findings contribute to a better understanding of the ApoL immune protein family.
Externí odkaz:
https://doaj.org/article/55aec271b9224cfebb44d9647b2ae582
Autor:
Henry R. Maun, Rajesh Vij, Benjamin T. Walters, Ashley Morando, Janet K. Jackman, Ping Wu, Alberto Estevez, Xiaocheng Chen, Yvonne Franke, Michael T. Lipari, Mark S. Dennis, Daniel Kirchhofer, Claudio Ciferri, Kelly M. Loyet, Tangsheng Yi, Charles Eigenbrot, Robert A. Lazarus, James T. Koerber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a prere
Externí odkaz:
https://doaj.org/article/731be2a1b0e94f0d9e6e6bb1c65b39da
Autor:
David S. Hewings, Johanna Heideker, Taylur P. Ma, Andrew P. AhYoung, Farid El Oualid, Alessia Amore, Gregory T. Costakes, Daniel Kirchhofer, Bradley Brasher, Thomas Pillow, Nataliya Popovych, Till Maurer, Carsten Schwerdtfeger, William F. Forrest, Kebing Yu, John Flygare, Matthew Bogyo, Ingrid E. Wertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase acti
Externí odkaz:
https://doaj.org/article/a36fd9ead45149f0b851c7d214b80597
Autor:
Daniel Kirchhofer, Amitabha Chaudhuri, Robert A. Lazarus, Thomas D. Wu, Lydia Santell, Ming-Hong Xie, S. Jack Lin, Ganesh A. Kolumam, Rajkumar Ganesan
Macrophage-stimulating protein (MSP) is a plasminogen-related growth factor and ligand for the receptor tyrosine kinase RON. The MSP/RON system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response. MSP bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab92bcdb36a8748185ea7692af62458f
https://doi.org/10.1158/1541-7786.c.6542076
https://doi.org/10.1158/1541-7786.c.6542076
Autor:
Daniel Kirchhofer, Amitabha Chaudhuri, Robert A. Lazarus, Thomas D. Wu, Lydia Santell, Ming-Hong Xie, S. Jack Lin, Ganesh A. Kolumam, Rajkumar Ganesan
PDF file - 504K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cea70a42c7644cf880ccb27c359620
https://doi.org/10.1158/1541-7786.22518687.v1
https://doi.org/10.1158/1541-7786.22518687.v1
Autor:
Daniel Kirchhofer, Wei-Qiang Gao, Stuart Bunting, Hartmut Koeppen, Alvin Gogineni, Mary J.C. Ludlam, Racquel Corpuz, Rajkumar Ganesan, Terry Lipari, Paul Moran, Bu-Er Wang, Wei Li
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated its tumor-promoting activity by use of a mouse orthotopic prostate cancer model. First, we compared the tumor growth of low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09a15a4b5768142274aad2a3c40e586
https://doi.org/10.1158/0008-5472.c.6499967.v1
https://doi.org/10.1158/0008-5472.c.6499967.v1